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1.发明授权公开(公告)号：US08846968B2
公开(公告)日：2014-09-30
申请号：US13692694
申请日：2012-12-03
发明人： Runpu Shen , Chunlei Lv , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C43/303 , C07F9/40 , C07B47/00 , C07C41/50 , C07C41/48
CPC分类号： C07C41/50 , C07B47/00 , C07C41/48 , C07C43/303 , C07F9/4015 , C07F9/4078
摘要： The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.
摘要翻译： 本发明涉及式（12）的2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一三烯的番茄红素中间体（12）及其4-甲基-5的中间体， 式（10）的5-二烷氧基-1-戊烯基-1-膦酸二烷基酯及其制备方法。 工艺路线简单，起始材料易于使用，成本低廉，在工业上是有价值的。
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公开(公告)号：US10131689B2
公开(公告)日：2018-11-20
申请号：US15033116
申请日：2014-10-27
发明人： Enmin Li , Yiyun Zhuang , Jue Wang , Xinqiang Sun , Xuejun Lao , Biwang Jiang
摘要： Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.
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公开(公告)号：US10028914B2
公开(公告)日：2018-07-24
申请号：US14786974
申请日：2014-03-14
发明人： Xinde Xu , Gang Chen , Xuejun Lao , Lihua Zhang , Xiaoxia Sun , Xiaoyue Jiang
IPC分类号： A61K31/122 , A61K9/16 , C07C41/26 , C07C41/34 , A61K9/00 , A61K9/48 , A61K31/09 , C12P7/66 , A23L33/10
摘要： The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities from a reaction solution after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The obtained reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-K[alpha] X-ray diffraction spectrum, has a strong peak at a diffraction angle 2[theta] being 18.9 DEG, and has a very strong absorption peak at a diffraction angle 2[theta] being 22.8 DEG. The reduction type coenzyme Q10 powder obtained in the present invention is in an incompletely crystallized state, has desirable stability and desirable oral bioavailability, and is suitable for use in applications such as dietary supplements, cosmetics or pharmaceuticals.
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公开(公告)号：US11920175B2
公开(公告)日：2024-03-05
申请号：US17259161
申请日：2019-07-09
发明人： Xinde Xu , Tian Xie , Shengfan Wang , Qiuyan Wang , Jianyong Zheng , Zhaowu Zeng , Xiaopu Yin , Xuejun Lao , Kangzhong Shao
IPC分类号： C07C403/24 , C12P23/00
CPC分类号： C12P23/00 , C07C403/24 , C07B2200/13 , C07C2601/16
摘要： A method for extracting and isolating a lutein crystal from a vegetable oil resin containing a lutein diester, comprises: dissolving lipase into deionized water to form an enzyme solution; dissolving a lutein extract into an alcohol solvent containing the deionized water to form a uniform alcohol solution; adding the enzyme solution to the alcohol solution for performing hydrolysis, and stirring same to obtain a lutein solution; filtering and performing filtration isolation on the lutein solution to obtain a crystalline; re-dissolving the crystalline into a non-polar organic solvent, and using deionized water for washing a water-soluble impurity; recycling and cooling the organic solvent to obtain a recrystallization; and isolating and drying the recrystallization to obtain the lutein crystal. In this method, selectivity is strong, reaction time is short, no waste water is produced, process is environment-friendly and suitable for industrial production, and obtained lutein crystal is high in purity and yield.
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