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1.发明申请Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists 审中-公开二氨基嘧啶衍生物作为选择性生长激素分泌受体（GHS-R）拮抗剂公开(公告)号：US20050171132A1
公开(公告)日：2005-08-04
申请号：US10948042
申请日：2004-09-23
申请人： Zhili Xin , Bo Liu , Gang Liu , Mei Liu , Michael Serby , Hongyu Zhao
发明人： Zhili Xin , Bo Liu , Gang Liu , Mei Liu , Michael Serby , Hongyu Zhao
IPC分类号： A61K31/506 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D43/02
CPC分类号： A61K31/506 , A61K31/505 , A61K31/519 , C04B35/632 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K2300/00
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，所述化合物的制备，含有该化合物的组合物以及该化合物在预防或治疗由 生长激素释放肽受体，包括Prader-Willi综合征，进食障碍，体重增加，饮食和运动后的体重减轻维持，肥胖症和与肥胖相关的疾病如非胰岛素依赖性糖尿病。
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公开(公告)号：US20050070712A1
公开(公告)日：2005-03-31
申请号：US10671723
申请日：2003-09-26
申请人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
发明人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P3/00 , C07D239/48 , C07D405/12 , C07D409/12 , C07D43/04
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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公开(公告)号：US20060173050A1
公开(公告)日：2006-08-03
申请号：US11337862
申请日：2006-01-23
申请人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
发明人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
IPC分类号： C07D213/84 , A61K31/44
CPC分类号： C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译： 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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4.发明申请Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists 审中-公开二氨基嘧啶衍生物作为生长激素分泌受体（GHS-R）拮抗剂公开(公告)号：US20050171131A1
公开(公告)日：2005-08-04
申请号：US10947823
申请日：2004-09-23
申请人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
发明人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
IPC分类号： A61K31/506 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D43/02
CPC分类号： A61K31/506 , A61K31/505 , A61K31/519 , C04B35/632 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K2300/00
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，所述化合物的制备，含有该化合物的组合物以及该化合物在预防或治疗由 生长激素释放肽受体，包括Prader-Willi综合征，进食障碍，体重增加，饮食和运动后的体重减轻维持，肥胖症和与肥胖相关的疾病如非胰岛素依赖性糖尿病。
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5.发明申请公开(公告)号：US20060089398A1
公开(公告)日：2006-04-27
申请号：US10797734
申请日：2004-03-10
申请人： Gang Liu , Hongyu Zhao , Michael Serby , Bo Liu , Zhili Xin , Lissa Nelson , Bruce Szczepankiewicz , Hing Sham
发明人： Gang Liu , Hongyu Zhao , Michael Serby , Bo Liu , Zhili Xin , Lissa Nelson , Bruce Szczepankiewicz , Hing Sham
IPC分类号： A61K31/42 , C07D261/18
CPC分类号： C07D261/18
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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公开(公告)号：US07888374B2
公开(公告)日：2011-02-15
申请号：US11337862
申请日：2006-01-23
申请人： Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
发明人： Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
IPC分类号： C07D213/84 , A61K31/44
CPC分类号： C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译： 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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公开(公告)号：US20060287356A1
公开(公告)日：2006-12-21
申请号：US11509383
申请日：2006-08-24
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： C07D498/02 , A61K31/4743
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
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8.发明授权Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂公开(公告)号：US07119205B2
公开(公告)日：2006-10-10
申请号：US10847144
申请日：2004-05-17
申请人： Rajesh R. Iyengar , Andrew S. Judd , Gang Zhao , Philip R. Kym , Hing L. Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard F. Clark , Ernst U. Frevert , Barbara L. Cool , Tianyuan Zhang , Robert F. Keyes , Todd M. Hansen , Zhili Xin
发明人： Rajesh R. Iyengar , Andrew S. Judd , Gang Zhao , Philip R. Kym , Hing L. Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard F. Clark , Ernst U. Frevert , Barbara L. Cool , Tianyuan Zhang , Robert F. Keyes , Todd M. Hansen , Zhili Xin
IPC分类号： C07D471/102 , A61K31/395
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
摘要翻译： 本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途 。
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9.发明申请Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂公开(公告)号：US20050038068A1
公开(公告)日：2005-02-17
申请号：US10847144
申请日：2004-05-17
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： A61K31/4743 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
摘要翻译： 本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途 。
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公开(公告)号：US07115767B2
公开(公告)日：2006-10-03
申请号：US10893484
申请日：2004-07-16
申请人： Bo Liu , Gang Liu , Lissa T. J. Nelson , Jyoti R. Patel , Hing L. Sham , Zhili Xin , Hongyu Zhao
发明人： Bo Liu , Gang Liu , Lissa T. J. Nelson , Jyoti R. Patel , Hing L. Sham , Zhili Xin , Hongyu Zhao
IPC分类号： C07C271/06 , A61K31/27 , C07D211/06 , A61K31/401
CPC分类号： C07C235/40 , C07C233/58 , C07C271/24 , C07C2602/10
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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