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公开(公告)号：US20220033845A1
公开(公告)日：2022-02-03
申请号：US17277663
申请日：2019-09-23
申请人： Zhimei DU , Bo JIANG , Xiaoyan TANG , Merck Sharp & Dohme Corp.
发明人： Zhimei Du , Bo Jiang , Xiaoyan Tang
摘要： The invention provides expression vectors for expressing recombinant proteins (e.g., biologics) in mammalian cells. Also provided are host cells comprising the expression vectors, methods of producing the recombinant proteins, and methods of propagating the expression vectors.
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公开(公告)号：US07138569B2
公开(公告)日：2006-11-21
申请号：US10114828
申请日：2002-04-02
CPC分类号： C12N15/8271 , A61K38/00 , A61K48/00 , C07K14/21 , C12N15/8261 , C12N15/8281 , C12N15/8282 , C12N15/8286 , C12N2799/021 , Y02A40/146 , Y02A40/162
摘要： The present invention relates to isolated nucleic acid molecules encoding a type III—secreted bacterial protein capable of modifying a cell death pathway in a plant cell. One aspect of the present invention involves an isolated nucleic acid molecule having a nucleotide sequence that encodes the HopPtoD2 protein of Pseudomonas syringae pv. syringae DC 3000. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. The nucleic acid molecules of the present invention can be used to impart disease resistance to a plant and to make a plant hypersusceptible to colonization by nonpathogenic bacteria.
摘要翻译： 本发明涉及编码能够修饰植物细胞中细胞死亡途径的III型分泌细菌蛋白质的分离的核酸分子。 本发明的一个方面涉及具有编码丁香假单胞菌（Pseudomonas syringae）pv的HopPtoD2蛋白的核苷酸序列的分离的核酸分子。 还公开了包含本发明的DNA分子的表达载体，宿主细胞和转基因植物。 本发明的核酸分子可以用于赋予植物抗病性，并使植物对非致病菌进行定植过敏。
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3.发明申请PSEUDOMONAS AVR AND HOP PROTEINS, THEIR ENCODING NUCLEIC ACIDS, AND USE THEREOF 有权PSEUDOMONAS AVR和HOP蛋白及其编码核酸及其用途公开(公告)号：US20070162994A1
公开(公告)日：2007-07-12
申请号：US11616609
申请日：2006-12-27
申请人： Alan Collmer , James Alfano , Samuel Cartinhour , David Schneider , Xiaoyan Tang
发明人： Alan Collmer , James Alfano , Samuel Cartinhour , David Schneider , Xiaoyan Tang
CPC分类号： C12N15/8282 , A61K38/00 , A61K48/00 , C07K14/21 , C12N15/8261 , C12N15/8271 , C12N15/8281 , C12N15/8286 , C12N2799/021 , Y02A40/146 , Y02A40/162
摘要： One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.
摘要翻译： 本发明的一个方面涉及编码无毒素蛋白或丁香假单胞菌pv的多肽的分离的核酸分子。 丁香假单胞菌DC 3000或与其互补的核酸分子。 还公开了包括本发明的DNA分子的表达载体，宿主细胞和转基因植物。 另一方面涉及分离的蛋白质或多肽以及含有它们的组合物。 本发明的各种核酸分子和蛋白质可以用于赋予植物抗病性，使得植物对非致病菌进行定植过敏，修饰细胞中的代谢途径，引起真核细胞死亡并治疗癌症， 以及抑制程序性细胞死亡。
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4.发明授权Pseudomonas AVR and HOP proteins, their encoding nucleic acids, and use thereof 有权假单胞菌AVR和HOP蛋白，其编码核酸及其用途公开(公告)号：US08716460B2
公开(公告)日：2014-05-06
申请号：US11616609
申请日：2006-12-27
CPC分类号： C12N15/8282 , A61K38/00 , A61K48/00 , C07K14/21 , C12N15/8261 , C12N15/8271 , C12N15/8281 , C12N15/8286 , C12N2799/021 , Y02A40/146 , Y02A40/162
摘要： One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.
摘要翻译： 本发明的一个方面涉及编码无毒素蛋白或丁香假单胞菌pv的多肽的分离的核酸分子。 丁香假单胞菌DC 3000或与其互补的核酸分子。 还公开了包括本发明的DNA分子的表达载体，宿主细胞和转基因植物。 另一方面涉及分离的蛋白质或多肽以及含有它们的组合物。 本发明的各种核酸分子和蛋白质可以用于赋予植物抗病性，使得植物对非致病菌进行定植过敏，修饰细胞中的代谢途径，引起真核细胞死亡并治疗癌症， 以及抑制程序性细胞死亡。
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