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公开(公告)号：US11117879B2
公开(公告)日：2021-09-14
申请号：US16848372
申请日：2020-04-14
发明人： Linyong Zhu , Yujie Hua , Qiuning Lin , Yiqing Zhang , Chunyan Bao , Xuepeng Zhong
IPC分类号： C08F2/46 , C08F2/50 , C08G61/04 , C07D291/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/52 , A61L31/04 , A61L31/06 , A61L31/14 , C07C235/12 , C08B37/08 , C08F220/68 , C08G69/10 , C08G73/06 , C08J3/075 , C08J3/28
摘要： This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A—a photosensitive polymer derivative, component B—the photoinitiator, and auxiliary component C—other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.
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2.发明申请公开(公告)号：US20200262802A1
公开(公告)日：2020-08-20
申请号：US16848372
申请日：2020-04-14
发明人： Linyong Zhu , Yujie Hua , Qiuning Lin , Yiqing Zhang , Chunyan BAO , Xuepeng Zhong
IPC分类号： C07D291/08 , C08B37/08 , C08G69/10 , C07C235/12 , C08G73/06 , C08F220/68 , C08J3/075 , C08J3/28 , A61L24/08 , A61L24/06 , A61L24/04 , A61L24/00 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/52 , A61L31/14 , A61L31/04 , A61L31/06
摘要： This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A—a photosensitive polymer derivative, component B—the photoinitiator, and auxiliary component C—other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.
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公开(公告)号：US20200262939A1
公开(公告)日：2020-08-20
申请号：US16848352
申请日：2020-04-14
发明人： Linyong Zhu , Yujie Hua , Qiuning Lin , Yiqing Zhang , Chunyan BAO , Xuepeng Zhong
IPC分类号： C08B37/08 , C07D291/08 , C07D273/01 , C08B11/12 , C08B37/00 , C08G69/48 , C08G65/334 , C08J3/075 , A61L26/00 , A61L24/08 , A61L24/04 , A61L24/00 , A61K31/722 , A61K31/728 , A61K31/727 , A61K31/738 , A61K31/737 , A61K31/785 , A61K31/77 , A61L27/18 , A61L27/20 , A61L27/52 , B33Y70/00
摘要： This invention provides a preparation, composition, product, and application of a photo-coupled synergistically crosslinked hydrogel material. The preparation includes dissolving Component A including a photosensitive polymer derivative having o-nitrobenzyl phototriggers and Component B including a polymer derivative having amine or alkene (double group) or sulfhydryl group in a biocompatible medium to obtain solution A and solution B, respectively; mixing the solution A and solution B homogeneously to obtain a hydrogel precursor solution; initiating photo-coupled synergistic crosslinking under an irradiation of a UV light to form the hydrogel. The irradiation causes the o-nitrobenzyl phototriggers to generate an aldehyde group/keto group or a nitroso group to initiate photo-coupled synergetic crosslinking. The photo-coupled synergistically crosslinked hydrogel has applications in tissue engineering, regenerative medicine, 3D printing and as a carrier of cell, protein or drug.
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