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1.发明授权Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 有权用于产生用于治疗疼痛和/或其他患者病症的异步神经反应的系统和方法公开(公告)号：US08509906B2
公开(公告)日：2013-08-13
申请号：US13544727
申请日：2012-07-09
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译： 公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。 根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。 该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致 对电信号的异步感觉神经元响应。
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公开(公告)号：US20130041425A1
公开(公告)日：2013-02-14
申请号：US13544727
申请日：2012-07-09
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
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3.发明授权Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 有权用于产生用于治疗疼痛和/或其他患者病症的异步神经反应的系统和方法公开(公告)号：US08255057B2
公开(公告)日：2012-08-28
申请号：US12362244
申请日：2009-01-29
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译： 公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。 根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。 该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致 对电信号的异步感觉神经元响应。
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公开(公告)号：US20130211487A1
公开(公告)日：2013-08-15
申请号：US13620307
申请日：2012-09-14
申请人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson , Konstantinos Alataris , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson , Konstantinos Alataris , Andre B. Walker
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/36171 , A61N1/3787
摘要： Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.
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5.发明申请SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS 有权用于产生异丙酚神经反应以治疗疼痛和/或其他患者病症的系统和方法公开(公告)号：US20100191307A1
公开(公告)日：2010-07-29
申请号：US12362244
申请日：2009-01-29
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译： 公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。 根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。 该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致 对电信号的异步感觉神经元响应。
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公开(公告)号：US08355797B2
公开(公告)日：2013-01-15
申请号：US12703683
申请日：2010-02-10
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/3605 , A61N1/36071 , A61N1/36132 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H10/60 , G16H20/40 , G16H20/70
摘要： Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.
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7.发明申请SYSTEMS AND METHODS FOR DELIVERING NEURAL THERAPY CORRELATED WITH PATIENT STATUS 有权用于输送与患者状态相关的神经治疗的系统和方法公开(公告)号：US20100211135A1
公开(公告)日：2010-08-19
申请号：US12703683
申请日：2010-02-10
IPC分类号： A61N1/02
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/3605 , A61N1/36071 , A61N1/36132 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H10/60 , G16H20/40 , G16H20/70
摘要： Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.
摘要翻译： 公开了治疗患者的治疗系统。 代表性治疗系统包括可植入脉冲发生器，电耦合到脉冲发生器的信号传递装置以及与可植入脉冲发生器电通信的遥控器。 脉冲发生器可以具有包含用于执行包括收集患者状态和刺激参数的过程的指令的计算机可读介质; 分析收集的患者状况和刺激参数; 以及建立包含对应于特定患者状态的优选刺激参数的偏好基线。
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公开(公告)号：US08457759B2
公开(公告)日：2013-06-04
申请号：US13620519
申请日：2012-09-14
申请人： Jon Parker , Andre B. Walker , Udai Singh
发明人： Jon Parker , Andre B. Walker , Udai Singh
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36071 , A61N1/36142 , A61N2001/083
摘要： System and methods for adjusting electrical therapy based on impedance changes are disclosed herein. A method in accordance with a particular embodiment includes applying a therapeutic electrical signal to a patient via an implanted portion of a patient stimulation system that includes a signal delivery device in electrical communication with a target neural population of the patient. The electrical signal is delivered in accordance with a signal delivery parameter having a first value. Using the implanted portion of the patient stimulation system, a change in an impedance of an electrical circuit that includes the signal delivery device is detected. Based at least in part on the detected impedance change, the method can further include automatically adjusting the value of the signal delivery parameter from the first value to a second value different from the first, without human intervention.
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公开(公告)号：US20130073007A1
公开(公告)日：2013-03-21
申请号：US13620519
申请日：2012-09-14
申请人： Jon Parker , Andre B. Walker , Udal Singh
发明人： Jon Parker , Andre B. Walker , Udal Singh
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36071 , A61N1/36142 , A61N2001/083
摘要： System and methods for adjusting electrical therapy based on impedance changes are disclosed herein. A method in accordance with a particular embodiment includes applying a therapeutic electrical signal to a patient via an implanted portion of a patient stimulation system that includes a signal delivery device in electrical communication with a target neural population of the patient. The electrical signal is delivered in accordance with a signal delivery parameter having a first value. Using the implanted portion of the patient stimulation system, a change in an impedance of an electrical circuit that includes the signal delivery device is detected. Based at least in part on the detected impedance change, the method can further include automatically adjusting the value of the signal delivery parameter from the first value to a second value different from the first, without human intervention.
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公开(公告)号：US20120209349A1
公开(公告)日：2012-08-16
申请号：US13447050
申请日：2012-04-13
申请人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
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