公开(公告)号：US08089037B2

公开(公告)日：2012-01-03

申请号：US12561204

申请日：2009-09-16

申请人： Matthias J. Schmand ,  Dongming Hu ,  Ziad Burbar

发明人： Matthias J. Schmand ,  Dongming Hu ,  Ziad Burbar

IPC分类号： H01L27/00

CPC分类号： G01T1/1648

摘要： A method, process and apparatus for compensating for changes to the gain of photo detectors in a nuclear imaging apparatus is disclosed. Specifically, embodiments detect positron annihilation event pulses using photo detectors. Changes to the gain of the photo detectors are compensated for by determining the relationship of a detected event pulse peak with a target event pulse peak. Based on the difference between these two peaks, a corrected gain is determined in a closed-loop control system. The corrected gain can be used to compensate for temperature changes that can affect the gain of the photo detectors.

摘要翻译： 公开了一种用于补偿核成像装置中光检测器的增益变化的方法，过程和装置。 具体地，实施例使用光电检测器检测正电子湮灭事件脉冲。 通过确定检测到的事件脉冲峰值与目标事件脉冲峰值的关系来补偿光电检测器增益的变化。 基于这两个峰之间的差异，在闭环控制系统中确定校正增益。 校正的增益可用于补偿可影响光电检测器增益的温度变化。

公开(公告)号：US20100065723A1

公开(公告)日：2010-03-18

申请号：US12561204

申请日：2009-09-16

申请人： Ziad Burbar ,  Dongming Hu ,  Matthias J. Schmand

发明人： Ziad Burbar ,  Dongming Hu ,  Matthias J. Schmand

IPC分类号： H03G3/20

CPC分类号： G01T1/1648

摘要： A method, process and apparatus for compensating for changes to the gain of photo detectors in a nuclear imaging apparatus is disclosed. Specifically, embodiments detect positron annihilation event pulses using photo detectors. Changes to the gain of the photo detectors are compensated for by determining the relationship of a detected event pulse peak with a target event pulse peak. Based on the difference between these two peaks, a corrected gain is determined in a closed-loop control system. The corrected gain can be used to compensate for temperature changes that can affect the gain of the photo detectors.

摘要翻译： 公开了一种用于补偿核成像装置中光检测器的增益变化的方法，过程和装置。 具体地，实施例使用光电检测器检测正电子湮灭事件脉冲。 通过确定检测到的事件脉冲峰值与目标事件脉冲峰值的关系来补偿光电检测器增益的变化。 基于这两个峰之间的差异，在闭环控制系统中确定校正增益。 校正的增益可用于补偿可影响光电检测器增益的温度变化。

公开(公告)号：US20080269594A1

公开(公告)日：2008-10-30

申请号：US12109605

申请日：2008-04-25

申请人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

发明人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

IPC分类号： A61B5/055 ,  A61B6/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/583 ,  G01R33/58 ,  G01T1/1603

摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.

摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。

公开(公告)号：US07768261B2

公开(公告)日：2010-08-03

申请号：US12109605

申请日：2008-04-25

申请人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden, Jr. ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

发明人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden, Jr. ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

IPC分类号： G01V3/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/583 ,  G01R33/58 ,  G01T1/1603

摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.

摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。

公开(公告)号：US20090114827A1

公开(公告)日：2009-05-07

申请号：US12232451

申请日：2008-09-17

申请人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew E. Martin ,  Matthias J. Schmand

发明人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew E. Martin ,  Matthias J. Schmand

IPC分类号： G01T1/164 ,  G01T1/20

CPC分类号： G01T1/1603 ,  A61B6/037 ,  G01T7/005

摘要： A method is disclosed for stabilizing the gain of a PET detection system with a cooling unit. The method includes determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.

摘要翻译： 公开了一种用于通过冷却单元稳定PET检测系统的增益的方法。 该方法包括确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度，使得增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。

公开(公告)号：US07772559B2

公开(公告)日：2010-08-10

申请号：US12232451

申请日：2008-09-17

申请人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew Martin ,  Matthias Schmand

发明人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew Martin ,  Matthias Schmand

IPC分类号： G01T1/164

CPC分类号： G01T1/1603 ,  A61B6/037 ,  G01T7/005

摘要： A method for stabilizing the gain of a PET detection system with a cooling unit includes: determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.

摘要翻译： 用于利用冷却单元稳定PET检测系统的增益的方法包括：确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度 增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。

公开(公告)号：US20050273007A1

公开(公告)日：2005-12-08

申请号：US10858637

申请日：2004-06-02

申请人： Ziad Burbar

发明人： Ziad Burbar

IPC分类号： A61B6/00

CPC分类号： A61B6/00

摘要： A method for detecting Alzheimer's disease using positron emission tomography. A normal population mean is obtained using PET. The normal population mean is obtained through the assimilation of a number of normal brain scans. Non-AD images and AD images are compared to observe differences in the uptake of FDG. PET scan results are expressed as relative uptake intensities and indexed by Brodmann's areas. An image is tested by comparing the distance of each mean for each Brodmann's area from the normal distribution. A Receiver Operating Characteristic curve is plotted based on the variation of deviation for the total population of both normal and probable Alzheimer's brain images. Variations in FDG uptake in a brain image as compared to the normal distribution confirms the probability of AD.

摘要翻译： 使用正电子发射断层扫描检测阿尔茨海默病的方法。 使用PET获得正常人群平均值。 正常人群的平均值是通过同化一些正常的脑部扫描获得的。 比较非AD图像和AD图像以观察FDG摄取的差异。 PET扫描结果表示为相对摄取强度，并由Brodmann的区域指数。 通过比较每个Brodmann区域的每个平均值与正态分布的距离来测试图像。 基于正常和可能的阿尔茨海默氏脑图像的总体的偏差变化绘制接收器操作特征曲线。 与正常分布相比，脑图像中FDG摄取的变化证实了AD的概率。

公开(公告)号：US07873405B2

公开(公告)日：2011-01-18

申请号：US10858637

申请日：2004-06-02

申请人： Ziad Burbar

发明人： Ziad Burbar

IPC分类号： A61B6/00

CPC分类号： A61B6/00

摘要： A method for detecting Alzheimer's disease using positron emission tomography. A normal population mean is obtained using PET. The normal population mean is obtained through the assimilation of a number of normal brain scans. Non-AD images and AD images are compared to observe differences in the uptake of FDG. PET scan results are expressed as relative uptake intensities and indexed by Brodmann's areas. An image is tested by comparing the distance of each mean for each Brodmann's area from the normal distribution. A Receiver Operating Characteristic curve is plotted based on the variation of deviation for the total population of both normal and probable Alzheimer's brain images. Variations in FDG uptake in a brain image as compared to the normal distribution confirms the probability of AD.

摘要翻译： 使用正电子发射断层扫描检测阿尔茨海默病的方法。 使用PET获得正常人群平均值。 正常人群的平均值是通过同化一些正常的脑部扫描获得的。 比较非AD图像和AD图像以观察FDG摄取的差异。 PET扫描结果表示为相对摄取强度，并由Brodmann的区域指数。 通过比较每个Brodmann区域的每个平均值与正态分布的距离来测试图像。 基于正常和可能的阿尔茨海默氏脑图像的总体的偏差变化绘制接收器操作特征曲线。 与正常分布相比，脑图像中FDG摄取的变化证实了AD的概率。

公开(公告)号：US20090020691A1

公开(公告)日：2009-01-22

申请号：US11779478

申请日：2007-07-18

申请人： Matthew E. Martin ,  Ziad Burbar ,  James Luke Corbeil

发明人： Matthew E. Martin ,  Ziad Burbar ,  James Luke Corbeil

IPC分类号： G01T7/00 ,  G12B13/00

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01R33/481 ,  G01T1/1603

摘要： A Positron Emission Tomography (PET) scanner may have a PET gantry, a calibration radiation source arranged rotatable in the PET gantry, and a drive mechanism coupled with the calibration radiation source, wherein the drive mechanism is formed by non ferromagnetic materials.

摘要翻译： 正电子发射断层扫描仪（PET）扫描器可以具有PET台架，可在PET机架中旋转设置的校准辐射源，以及与校准辐射源耦合的驱动机构，其中驱动机构由非铁磁材料形成。

公开(公告)号：US07501619B2

公开(公告)日：2009-03-10

申请号：US11779478

申请日：2007-07-18

申请人： Matthew E. Martin ,  Ziad Burbar ,  James Luke Corbeil

发明人： Matthew E. Martin ,  Ziad Burbar ,  James Luke Corbeil

IPC分类号： G01D18/00

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01R33/481 ,  G01T1/1603

摘要： A Positron Emission Tomography (PET) scanner may have a PET gantry, a calibration radiation source arranged rotatable in the PET gantry, and a drive mechanism coupled with the calibration radiation source, wherein the drive mechanism is formed by non ferromagnetic materials.

摘要翻译： 正电子发射断层扫描仪（PET）扫描器可以具有PET台架，可在PET机架中旋转设置的校准辐射源，以及与校准辐射源耦合的驱动机构，其中驱动机构由非铁磁材料形成。