公开(公告)号：US20080269594A1

公开(公告)日：2008-10-30

申请号：US12109605

申请日：2008-04-25

申请人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

发明人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

IPC分类号： A61B5/055 ,  A61B6/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/583 ,  G01R33/58 ,  G01T1/1603

摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.

摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。

公开(公告)号：US07768261B2

公开(公告)日：2010-08-03

申请号：US12109605

申请日：2008-04-25

申请人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden, Jr. ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

发明人： Rainer Paul ,  Matthias J. Schmand ,  Charles H. Hayden, Jr. ,  James Corbeil ,  Christian J. Michel ,  Ziad Burbar ,  Volker Matschl

IPC分类号： G01V3/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/583 ,  G01R33/58 ,  G01T1/1603

摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.

摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。

公开(公告)号：US20090114827A1

公开(公告)日：2009-05-07

申请号：US12232451

申请日：2008-09-17

申请人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew E. Martin ,  Matthias J. Schmand

发明人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew E. Martin ,  Matthias J. Schmand

IPC分类号： G01T1/164 ,  G01T1/20

CPC分类号： G01T1/1603 ,  A61B6/037 ,  G01T7/005

摘要： A method is disclosed for stabilizing the gain of a PET detection system with a cooling unit. The method includes determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.

摘要翻译： 公开了一种用于通过冷却单元稳定PET检测系统的增益的方法。 该方法包括确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度，使得增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。

公开(公告)号：US20100065723A1

公开(公告)日：2010-03-18

申请号：US12561204

申请日：2009-09-16

申请人： Ziad Burbar ,  Dongming Hu ,  Matthias J. Schmand

发明人： Ziad Burbar ,  Dongming Hu ,  Matthias J. Schmand

IPC分类号： H03G3/20

CPC分类号： G01T1/1648

摘要： A method, process and apparatus for compensating for changes to the gain of photo detectors in a nuclear imaging apparatus is disclosed. Specifically, embodiments detect positron annihilation event pulses using photo detectors. Changes to the gain of the photo detectors are compensated for by determining the relationship of a detected event pulse peak with a target event pulse peak. Based on the difference between these two peaks, a corrected gain is determined in a closed-loop control system. The corrected gain can be used to compensate for temperature changes that can affect the gain of the photo detectors.

摘要翻译： 公开了一种用于补偿核成像装置中光检测器的增益变化的方法，过程和装置。 具体地，实施例使用光电检测器检测正电子湮灭事件脉冲。 通过确定检测到的事件脉冲峰值与目标事件脉冲峰值的关系来补偿光电检测器增益的变化。 基于这两个峰之间的差异，在闭环控制系统中确定校正增益。 校正的增益可用于补偿可影响光电检测器增益的温度变化。

公开(公告)号：US08089037B2

公开(公告)日：2012-01-03

申请号：US12561204

申请日：2009-09-16

申请人： Matthias J. Schmand ,  Dongming Hu ,  Ziad Burbar

发明人： Matthias J. Schmand ,  Dongming Hu ,  Ziad Burbar

IPC分类号： H01L27/00

CPC分类号： G01T1/1648

摘要： A method, process and apparatus for compensating for changes to the gain of photo detectors in a nuclear imaging apparatus is disclosed. Specifically, embodiments detect positron annihilation event pulses using photo detectors. Changes to the gain of the photo detectors are compensated for by determining the relationship of a detected event pulse peak with a target event pulse peak. Based on the difference between these two peaks, a corrected gain is determined in a closed-loop control system. The corrected gain can be used to compensate for temperature changes that can affect the gain of the photo detectors.

摘要翻译： 公开了一种用于补偿核成像装置中光检测器的增益变化的方法，过程和装置。 具体地，实施例使用光电检测器检测正电子湮灭事件脉冲。 通过确定检测到的事件脉冲峰值与目标事件脉冲峰值的关系来补偿光电检测器增益的变化。 基于这两个峰之间的差异，在闭环控制系统中确定校正增益。 校正的增益可用于补偿可影响光电检测器增益的温度变化。

公开(公告)号：US07579599B2

公开(公告)日：2009-08-25

申请号：US11941562

申请日：2007-11-16

申请人： Nan Zhang ,  Volker Matschl ,  Niraj K. Doshi ,  Matthias J. Schmand

发明人： Nan Zhang ,  Volker Matschl ,  Niraj K. Doshi ,  Matthias J. Schmand

IPC分类号： G01T1/164

CPC分类号： A61B6/037 ,  A61B6/56

摘要： A medical device with a high voltage connection line for carrying a high DC supply voltage has a control unit generating said high DC supply voltage which is fed through a first AC block unit to said high voltage connection line and generating a digital control signal fed through a first AC coupling unit to said high voltage connection line, and a remotely located unit a second AC block unit coupled to said high voltage connection line for receiving said high DC supply voltage and a second AC coupling unit coupled to said high voltage connection line for receiving said digital control signal.

摘要翻译： 具有用于承载高直流电源电压的高压连接线的医疗装置具有产生所述高直流电源电压的控制单元，所述高直流电源电压通过第一AC块单元馈送到所述高压连接线，并产生通过 第一AC耦合单元连接到所述高压连接线，以及远程定位单元，耦合到所述高压连接线的第二AC块单元，用于接收所述高DC电源电压;以及第二AC耦合单元，耦合到所述高压连接线，用于接收 所述数字控制信号。

公开(公告)号：US20090072151A1

公开(公告)日：2009-03-19

申请号：US11941562

申请日：2007-11-16

申请人： Nan Zhang ,  Volker Matschl ,  Niraj K. Doshi ,  Matthias J. Schmand

发明人： Nan Zhang ,  Volker Matschl ,  Niraj K. Doshi ,  Matthias J. Schmand

IPC分类号： G01T1/164 ,  H04B3/54

CPC分类号： A61B6/037 ,  A61B6/56

摘要： A medical device with a high voltage connection line for carrying a high DC supply voltage has a control unit generating said high DC supply voltage which is fed through a first AC block unit to said high voltage connection line and generating a digital control signal fed through a first AC coupling unit to said high voltage connection line, and a remotely located unit a second AC block unit coupled to said high voltage connection line for receiving said high DC supply voltage and a second AC coupling unit coupled to said high voltage connection line for receiving said digital control signal.

摘要翻译： 具有用于承载高直流电源电压的高压连接线的医疗装置具有产生所述高直流电源电压的控制单元，所述高直流电源电压通过第一AC块单元馈送到所述高压连接线，并产生通过 第一AC耦合单元连接到所述高压连接线，以及远程定位单元，耦合到所述高压连接线的第二AC块单元，用于接收所述高DC电源电压;以及第二AC耦合单元，耦合到所述高压连接线，用于接收 所述数字控制信号。

公开(公告)号：US20090108206A1

公开(公告)日：2009-04-30

申请号：US12260966

申请日：2008-10-29

申请人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

发明人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

IPC分类号： G01T1/164 ,  G01V3/00

CPC分类号： G01R33/28 ,  A61B5/150992 ,  G01R33/481 ,  G01T1/1603

摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

摘要翻译： 用于PET成像应用的自动采血系统，其可以在MR扫描器的视野（FOV）中或非常接近的范围内操作，例如在组合的MR / PET成像系统中。 辐射检测器使用APD（雪崩光电二极管）从正电子 - 电子湮灭光子被吸收的晶体中收集闪烁光。 必要的伽马屏蔽由合适的屏蔽材料制成，优选钨聚合物复合材料。 由于APD相当小并且磁性不敏感，所以它们可以在无扰动的MR设备的强磁场中操作。

公开(公告)号：US09606199B2

公开(公告)日：2017-03-28

申请号：US12260966

申请日：2008-10-29

申请人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

发明人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

IPC分类号： G01R33/28 ,  A61B5/15 ,  G01R33/48 ,  G01T1/16

CPC分类号： G01R33/28 ,  A61B5/150992 ,  G01R33/481 ,  G01T1/1603

摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

公开(公告)号：US09091771B2

公开(公告)日：2015-07-28

申请号：US13539915

申请日：2012-07-02

申请人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

发明人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

IPC分类号： G01T1/29 ,  A61B6/03 ,  G01T1/00 ,  A61B6/00

CPC分类号： G01T1/2985 ,  A61B6/00 ,  A61B6/037 ,  G01T1/00

摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.

摘要翻译： 提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。 获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。 数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。 这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少 给予患者剂量或扫描时间相同的图像质量。