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    Porous metal device for regenerating soft tissue-to-bone interface
    2.
    发明授权
    Porous metal device for regenerating soft tissue-to-bone interface 有权
    用于再生软组织至骨界面的多孔金属装置

    公开(公告)号：US09055977B2

    公开(公告)日：2015-06-16

    申请号：US13679041

    申请日：2012-11-16

    申请人： Zimmer, Inc.

    发明人： Tao Jiang ,  Jian Q. Yao ,  Hali Wang ,  Timothy A. Hoeman ,  Ray Zubok ,  John Chernosky ,  Keith A. Roby

    IPC分类号： A61F2/08 ,  A61B17/68 ,  A61B17/08 ,  A61L27/56 ,  A61L27/04

    CPC分类号： A61F2/0811 ,  A61B17/68 ,  A61F2002/0858 ,  A61F2002/0888 ,  A61F2250/0021 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61L27/04 ,  A61L27/56

    摘要： The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.

    摘要翻译： 本公开在一些方面涉及用于将软组织固定在骨上的矫形植入物及其使用方法。 一种特定的植入物包括具有用于促进骨向内生长的孔的第一暴露的多孔表面区域和具有促进软组织向内生长的孔的第二暴露多孔表面。 第一暴露的多孔表面区域的至少一些孔可能被接种有骨细胞因子，并且第二暴露的多孔表面区域的至少一些孔可能被纤维细胞因子接种。 这样的矫形植入物可以有利地促进软组织再生成骨界面。

    POROUS METAL DEVICE FOR REGENERATING SOFT TISSUE-TO-BONE INTERFACE
    4.
    发明申请
    POROUS METAL DEVICE FOR REGENERATING SOFT TISSUE-TO-BONE INTERFACE 审中-公开
    用于再生软骨组织界面的多孔金属装置

    公开(公告)号：US20150257871A1

    公开(公告)日：2015-09-17

    申请号：US14727008

    申请日：2015-06-01

    申请人： Zimmer, Inc.

    发明人： Tao Jiang ,  Jian Q. Yao ,  Hali Wang ,  Timothy A. Hoeman ,  Ray Zubok ,  John Chernosky ,  Keith A. Roby

    IPC分类号： A61F2/08 ,  A61B17/68

    CPC分类号： A61F2/0811 ,  A61B17/68 ,  A61F2002/0858 ,  A61F2002/0888 ,  A61F2250/0021 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61L27/04 ,  A61L27/56

    摘要： The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.

    摘要翻译： 本公开在一些方面涉及用于将软组织固定在骨上的矫形植入物及其使用方法。 一种特定的植入物包括具有用于促进骨向内生长的孔的第一暴露的多孔表面区域和具有促进软组织向内生长的孔的第二暴露多孔表面。 第一暴露的多孔表面区域的至少一些孔可能被接种有骨细胞因子，并且第二暴露的多孔表面区域的至少一些孔可能被纤维细胞因子接种。 这样的矫形植入物可以有利地促进软组织再生成骨界面。

    Supports and methods for promoting integration of cartilage tissue explants
    5.
    发明授权
    Supports and methods for promoting integration of cartilage tissue explants 有权

    公开(公告)号：US10167447B2

    公开(公告)日：2019-01-01

    申请号：US14299314

    申请日：2014-06-09

    申请人： Zimmer, Inc.

    发明人： Jian Q. Yao ,  Hali Wang

    IPC分类号： C12N5/077 ,  A61L27/38 ,  A61L27/36 ,  A61L27/54

    摘要： The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.

    SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS
    7.
    发明申请
    SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS 审中-公开
    用于促进组织织物组合整合的支持和方法

    公开(公告)号：US20140335612A1

    公开(公告)日：2014-11-13

    申请号：US14299314

    申请日：2014-06-09

    申请人： Zimmer, Inc.

    发明人： Jian Q. Yao ,  Hali Wang

    IPC分类号： C12N5/077

    CPC分类号： C12N5/0655 ,  A61L27/3612 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2430/06 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/20 ,  C12N2501/30

    摘要： The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.

    摘要翻译： 本公开提供了用于制备用于修复软骨缺陷的软骨组合物的组织支撑体和方法，所述软骨组合物通过扩大和整合衍生自供体或工程组织的小软骨组织片而制备。 本文所述的方法和支持促进细胞迁移和相邻组织块在培养物中的整合以形成软骨组合物。 还描述了使用软骨组合物的软骨修复方法。