公开(公告)号：US20180346584A1

公开(公告)日：2018-12-06

申请号：US16100485

申请日：2018-08-10

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph Leon Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K16/28 ,  C07K14/52 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20170320931A1

公开(公告)日：2017-11-09

申请号：US15648203

申请日：2017-07-12

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/715 ,  C07K14/52 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20140141485A1

公开(公告)日：2014-05-22

申请号：US14138199

申请日：2013-12-23

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。

公开(公告)号：US20130330339A1

公开(公告)日：2013-12-12

申请号：US13972186

申请日：2013-08-21

申请人： ZymoGenetics, Inc.

发明人： Stacey R. Dillon ,  Brandon J. Harder

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/70575 ,  G01N2333/70578 ,  G01N2800/52

摘要： The present invention provides a method of measuring the levels of BLyS/APRIL heterotrimers (HT) in a biological sample, in a preferred embodiment, in serum. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with HT antagonists, either singly or in combination with other immune suppressive drugs.

摘要翻译： 本发明提供了在优选实施方案中在血清中测量生物样品中BLyS / APRIL异源三聚体（HT）的水平的方法。 诊断测定可用于预测个体发展或目前患有自身免疫性疾病如SLE的可能性，以及用于治疗临床诊断为自身免疫性疾病的个体的方法。 该诊断测试用于预测患者单独或与其他免疫抑制药物组合对特定药物治疗特别是用HT拮抗剂治疗的可能性。

公开(公告)号：US10227415B2

公开(公告)日：2019-03-12

申请号：US15648203

申请日：2017-07-12

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C12N5/10 ,  C12N15/12 ,  C07K16/28 ,  C07K14/52 ,  C07K14/715 ,  A61K38/00

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20170369580A1

公开(公告)日：2017-12-28

申请号：US15701214

申请日：2017-09-11

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph Leon Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A Gross ,  Stacey R. Dillon

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US09738700B2

公开(公告)日：2017-08-22

申请号：US14937919

申请日：2015-11-11

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/705 ,  C07K14/715 ,  C07K14/52 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K14/715 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US09725506B2

公开(公告)日：2017-08-08

申请号：US14192911

申请日：2014-02-28

申请人： ZymoGenetics, Inc. ,  University of Washington

发明人： Stacey R. Dillon ,  Jane A. Gross ,  Keith B. Elkon

IPC分类号： A61K38/00 ,  C07K16/24 ,  G01N33/50 ,  C07K14/705 ,  G01N33/564

CPC分类号： C07K16/24 ,  C07K14/70578 ,  G01N33/5091 ,  G01N33/564 ,  G01N2333/70575 ,  G01N2800/042 ,  G01N2800/065 ,  G01N2800/101 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/347

摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs.

公开(公告)号：US20140220014A1

公开(公告)日：2014-08-07

申请号：US14192911

申请日：2014-02-28

申请人： University of Washington ,  ZymoGenetics, Inc.

发明人： Stacey R. Dillon ,  Jane A. Gross ,  Keith B. Elkon

IPC分类号： C07K16/24 ,  G01N33/564 ,  C07K14/705

CPC分类号： C07K16/24 ,  C07K14/70578 ,  G01N33/5091 ,  G01N33/564 ,  G01N2333/70575 ,  G01N2800/042 ,  G01N2800/065 ,  G01N2800/101 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/347

摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs

摘要翻译： 本发明提供了一种测量生物样品中的BCMA水平，特别是B细胞表面的方法。 诊断测定法可用于预测个体发展或目前患有自身免疫性疾病如SLE的可能性，以及用于治疗临床诊断患有自身免疫性疾病的个体的方法。 该诊断测试用于预测患者对特定药物治疗的反应的可能性，特别是用BLyS拮抗剂单独或与其它免疫抑制药物组合

公开(公告)号：US20130143265A1

公开(公告)日：2013-06-06

申请号：US13741036

申请日：2013-01-14

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Anglea K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。