公开(公告)号：US20180346584A1

公开(公告)日：2018-12-06

申请号：US16100485

申请日：2018-08-10

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph Leon Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K16/28 ,  C07K14/52 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20170320931A1

公开(公告)日：2017-11-09

申请号：US15648203

申请日：2017-07-12

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/715 ,  C07K14/52 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20150010946A1

公开(公告)日：2015-01-08

申请号：US14296488

申请日：2014-06-05

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Jane A. Gross ,  Angela K. Hammond

IPC分类号： C07K16/24

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20140141485A1

公开(公告)日：2014-05-22

申请号：US14138199

申请日：2013-12-23

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。

公开(公告)号：US20180155418A1

公开(公告)日：2018-06-07

申请号：US15429750

申请日：2017-02-10

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Jane A. Gross ,  Angela K. Hammond

IPC分类号： C07K16/24 ,  C07K14/52 ,  A61K38/00 ,  C07K14/47

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US20170204190A1

公开(公告)日：2017-07-20

申请号：US15476006

申请日：2017-03-31

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20130309231A1

公开(公告)日：2013-11-21

申请号：US13956499

申请日：2013-08-01

申请人： Zymogenetics, Inc.

发明人： Mark W. Rixon ,  Jane A. Gross

IPC分类号： C07K16/24

CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30

摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供改进的可溶性跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体。

公开(公告)号：US10227415B2

公开(公告)日：2019-03-12

申请号：US15648203

申请日：2017-07-12

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C12N5/10 ,  C12N15/12 ,  C07K16/28 ,  C07K14/52 ,  C07K14/715 ,  A61K38/00

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US09738700B2

公开(公告)日：2017-08-22

申请号：US14937919

申请日：2015-11-11

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Theodore E. Whitmore ,  Angela K. Hammond ,  Julia E. Novak ,  Jane A. Gross ,  Stacey R. Dillon

IPC分类号： C07K14/705 ,  C07K14/715 ,  C07K14/52 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K14/715 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US09725506B2

公开(公告)日：2017-08-08

申请号：US14192911

申请日：2014-02-28

申请人： ZymoGenetics, Inc. ,  University of Washington

发明人： Stacey R. Dillon ,  Jane A. Gross ,  Keith B. Elkon

IPC分类号： A61K38/00 ,  C07K16/24 ,  G01N33/50 ,  C07K14/705 ,  G01N33/564

CPC分类号： C07K16/24 ,  C07K14/70578 ,  G01N33/5091 ,  G01N33/564 ,  G01N2333/70575 ,  G01N2800/042 ,  G01N2800/065 ,  G01N2800/101 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/347

摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs.