公开(公告)号：US10888380B2

公开(公告)日：2021-01-12

申请号：US16171515

申请日：2018-10-26

申请人： Alcon Research, Ltd.

发明人： Zsolt Bor ,  Imre Hegedus

IPC分类号： A61B34/10 ,  G06T7/73 ,  G06T7/00

摘要： Systems and methods for intraocular lens selection include receiving, by one or more computing devices implementing a prediction engine, pre-operative multi-dimensional images of an eye; extracting, by the prediction engine, pre-operative measurements of the eye based on the pre-operative images; estimating, by the prediction engine using a prediction model based on a machine learning strategy, a post-operative position of an intraocular lens based on the extracted pre-operative measurements; selecting a power of the intraocular lens based on the estimated post-operative position of the intraocular lens; and selecting the intraocular lens based on the selected power. In some embodiments, the systems and methods further include receiving post-operative multi-dimensional images of the eye after implantation of the selected intraocular lens, extracting post-operative measurements of the eye, and updating the prediction model based on the pre-operative measurements and the post-operative measurements.

公开(公告)号：US10478532B2

公开(公告)日：2019-11-19

申请号：US15842991

申请日：2017-12-15

申请人： Alcon Research, Ltd.

发明人： Glenn Robert Sussman ,  Mikhail Boukhny ,  John Morgan Bourne

IPC分类号： A61M1/00 ,  A61F9/007

摘要： A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow.

公开(公告)号：US10328025B2

公开(公告)日：2019-06-25

申请号：US15989383

申请日：2018-05-25

申请人： ALCON RESEARCH, LTD.

发明人： Howard Allen Ketelson ,  David L. Meadows

IPC分类号： A61K9/107 ,  B01F17/00 ,  A61K9/00

摘要： The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

公开(公告)号：US10070990B2

公开(公告)日：2018-09-11

申请号：US13314625

申请日：2011-12-08

申请人： Brian W. McDonell ,  Filip Finodeyev

发明人： Brian W. McDonell ,  Filip Finodeyev

IPC分类号： A61F9/007 ,  A61B17/32 ,  A61M25/00 ,  A61B17/00

CPC分类号： A61F9/00763 ,  A61B2017/00544 ,  A61F9/007 ,  A61F9/00736 ,  A61M25/0054

摘要： In one exemplary aspect, the present disclosure is directed to a system. The system includes a pneumatic surgical instrument and a surgical console operable to provide compressed gas to the pneumatic surgical instrument. Additionally, the system includes a pneumatic drive line coupling the pneumatic surgical instrument to the surgical console. The pneumatic drive line has an internal bore configured to deliver the compressed gas to the pneumatic surgical instrument. The internal bore has a non-uniform cross-section along a length of the pneumatic drive line.

公开(公告)号：US10039565B2

公开(公告)日：2018-08-07

申请号：US15075861

申请日：2016-03-21

申请人： Alcon Research, Ltd.

发明人： Guido Vezzu

IPC分类号： A61B17/285 ,  A61B17/29 ,  A61B17/28 ,  A61F9/007 ,  A61B17/00 ,  A61B17/30 ,  A61B17/32

摘要： Membrane forceps for performing an ILM or ERM peel procedure include a handle, a tube extending from the handle, and forceps jaws extending from the tube. The forceps jaws may be configured to grasp an ILM or ERM, and may include an outer surface having a roughened surface. The roughened surface may be structurally configured to aid in gaining an edge of the ILM or ERM.

公开(公告)号：US09910338B2

公开(公告)日：2018-03-06

申请号：US14569798

申请日：2014-12-15

申请人： Alcon Research, Ltd.

发明人： Ronald T. Smith

IPC分类号： A61B18/18 ,  G02F1/29 ,  G02F1/13 ,  A61F9/008 ,  G02F1/1334

CPC分类号： G02F1/29 ,  A61F9/00823 ,  A61F2009/00863 ,  A61F2009/00897 ,  G02F1/1326 ,  G02F1/1334 ,  G02F1/292

摘要： In certain embodiments, a system may include a housing, one or more lenses, and a scanning system. The housing has an interior region. A lens is disposed within the interior region and transmits a light beam. The scanning system is disposed within the interior region and comprises a number of scanning cells, where each scanning cell comprises an electro-optical (EO) material. The scanning system performs the following for a number of iterations to yield a spot pattern: receive one or more voltages and electrically steer the light beam with the EO material from a current direction to a next direction in response to the voltages.

公开(公告)号：US09861522B2

公开(公告)日：2018-01-09

申请号：US13325549

申请日：2011-12-14

申请人： Gary Sorensen ,  Glenn Sussman

发明人： Gary Sorensen ,  Glenn Sussman

IPC分类号： A61F9/00 ,  A61F9/007 ,  A61M5/142

CPC分类号： A61F9/00745 ,  A61M5/14228

摘要： An ophthalmic surgical hand piece comprises a driver coupled to a horn. The horn is coupled to a needle. An aspiration pump is integral with the hand piece and is located close to the needle. A rigid length of aspiration line is located between the aspiration pump and the needle. An optional pressure sensor is located between the aspiration pump and the needle as well.

公开(公告)号：US09662398B2

公开(公告)日：2017-05-30

申请号：US14539996

申请日：2014-11-12

申请人： Alcon Research, Ltd.

发明人： Masood A. Chowhan ,  Malay Ghosh ,  Bahram Asgharian ,  Wesley Weshin Han

IPC分类号： A61K31/165 ,  A61K31/765 ,  A61K47/36 ,  A61K9/00 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K9/14

CPC分类号： A61K47/36 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/14 ,  A61K9/146 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/165 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/186 ,  A61K47/32 ,  A61K47/38

摘要： The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

公开(公告)号：US09662200B2

公开(公告)日：2017-05-30

申请号：US14475801

申请日：2014-09-03

申请人： Alcon Research, Ltd.

发明人： Sushant Muchhala ,  David A. Downer

IPC分类号： A61F2/16

CPC分类号： A61F2/1678 ,  A61F2/167

摘要： The present invention is directed to an intraocular lens delivery system with a multi-segment plunger. More particularly, the present invention relates to an intraocular lens delivery device that includes a disposable plunger tip segment that can be attached and removed from a reusable plunger base segment.

公开(公告)号：US09533053B2

公开(公告)日：2017-01-03

申请号：US14304124

申请日：2014-06-13

申请人： Alcon Research, Ltd.

发明人： Daniel A. Gamache ,  Laman Alani ,  Malay Ghosh ,  Francisco Javier Galan ,  Nuria Carreras Perdiguer ,  Onkar N. Singh

IPC分类号： A61K31/335 ,  A01N43/02 ,  A61K47/00 ,  A61K47/40 ,  A61K9/00 ,  A61K47/32 ,  A61K9/08 ,  A61K47/48 ,  C08B37/16 ,  C08L5/16 ,  A61K47/10 ,  B82Y5/00

CPC分类号： A61K31/335 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/186 ,  A61K47/32 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0015 ,  C08L5/16

摘要： The present invention is an ophthalmic composition containing a relatively high concentration of olopatadine. The composition is typically an ophthalmic aqueous solution containing relatively high concentrations of olopatadine solubilized within the solution. The composition is preferably capable of providing enhanced relief from symptoms of ocular allergic conjunctivitis, particularly late phase symptoms of ocular allergic conjunctivitis.

摘要翻译： 本发明是含有相对高浓度的奥洛他定的眼用组合物。 组合物通常是含有溶解在溶液中的相当高浓度的奥洛他定的眼用水溶液。 该组合物优选能够增强眼部过敏性结膜炎症状的缓解，特别是眼部过敏性结膜炎的晚期症状。