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    Therapeutic binding agents against MUC-1 antigen and methods for their use
    2.
    发明授权
    Therapeutic binding agents against MUC-1 antigen and methods for their use 有权

    公开(公告)号：US07147850B2

    公开(公告)日：2006-12-12

    申请号：US09994466

    申请日：2001-11-26

    申请人： Ragupathy Madiyalakan

    发明人： Ragupathy Madiyalakan

    IPC分类号： A61K39/395

    CPC分类号： C07K16/3015 ,  A61K39/00 ,  A61K41/0057 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55577 ,  C07K16/30 ,  C07K2317/34

    摘要： The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.The invention also provides methods for therapeutically treating a mammal bearing a tumor comprising administering to the mammal an effective amount of a therapeutic composition consisting essentially of a binding agent that specifically binds to an epitope of tumor-associated MUC1, wherein the mammal generates an immune response that comprises an antibody that specifically binds to an epitope of tumor-associated MUC1 that is different from the epitope of tumor associated MUC1 that is specifically bound by the binding agent.

    Binding agents and their use in targeting tumor cells
    5.
    发明申请
    Binding agents and their use in targeting tumor cells 审中-公开
    结合剂及其在靶向肿瘤细胞中的应用

    公开(公告)号：US20050260208A1

    公开(公告)日：2005-11-24

    申请号：US10510361

    申请日：2003-04-11

    申请人： Hubert Eng ,  Birgit Schultes

    发明人： Hubert Eng ,  Birgit Schultes

    IPC分类号： A61K9/19 ,  A61K39/395 ,  A61K45/00 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30

    CPC分类号： C07K16/3069 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  A61K2300/00

    摘要： The present invention concerns methods and compositions for administering a binding agent to a patient wherein the patient generates a response to autologous tumor. The binding agents target apoptotic tumor cells and facilitates the uptake of these apoptotic tumor cell are taken up by dendritic cells or other antigen presenting cells for processing and presentation to the immune system without the expression of circulating tumor-associated antigen (or without the need of circulating tumor antigen).

    摘要翻译： 本发明涉及向患者施用结合剂的方法和组合物，其中患者产生对自体肿瘤的应答。 结合剂靶向凋亡性肿瘤细胞，促进这些凋亡性肿瘤细胞的摄取被树突细胞或其他抗原呈递细胞吸收，用于处理和呈递到免疫系统，而不表达循环肿瘤相关抗原（或不需要 循环肿瘤抗原）。

    BINDING AGENTS AND THEIR USE IN TARGETING TUMOR CELLS
    6.
    发明申请
    BINDING AGENTS AND THEIR USE IN TARGETING TUMOR CELLS 审中-公开
    结合剂及其在靶向肿瘤细胞中的应用

    公开(公告)号：US20090291075A1

    公开(公告)日：2009-11-26

    申请号：US12334182

    申请日：2008-12-12

    申请人： Hubert Eng ,  Birgit C. Schultes

    发明人： Hubert Eng ,  Birgit C. Schultes

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/3069 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  A61K2300/00

    摘要： The present invention concerns methods and compositions for administering a binding agent to a patient wherein the patient generates a response to autologous tumor. The binding agents target apoptotic tumor cells and facilitates the uptake of these apoptotic tumor cell are taken up by dendritic cells or other antigen presenting cells for processing and presentation to the immune system without the expression of circulating tumor-associated antigen (or without the need of circulating tumor antigen).

    摘要翻译： 本发明涉及向患者施用结合剂的方法和组合物，其中患者产生对自体肿瘤的应答。 结合剂靶向凋亡性肿瘤细胞，促进这些凋亡性肿瘤细胞的摄取被树突细胞或其他抗原呈递细胞吸收，用于处理和呈递到免疫系统，而不表达循环肿瘤相关抗原（或不需要 循环肿瘤抗原）。