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    Apolipoprotein E genotyping and accompanying internet-based health management system
    1.
    发明授权
    Apolipoprotein E genotyping and accompanying internet-based health management system 有权
    载脂蛋白E基因分型和伴随的基于互联网的健康管理系统

    公开(公告)号：US07842506B2

    公开(公告)日：2010-11-30

    申请号：US11702961

    申请日：2007-02-06

    Applicant: Christopher Hall ,  Vance Lanier, Jr. ,  David T. Shewmake

    Inventor： Christopher Hall ,  Vance Lanier, Jr. ,  David T. Shewmake

    IPC: G01N33/92

    CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  G01N33/92 ,  G06F19/00 ,  G06F19/18 ,  G06Q50/24

    Abstract: The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.

    Abstract translation: 本发明提供一种用于监测患者的系统，其包括：1）测量来自患者的Apo E基因型或其衍生物的血液检测以产生Apo B信息; 2）接收并存储患者Apo E信息的数据库; 以及3）基于因特网的系统，其连接到所述数据库并被配置为利用所述算法处理所述Apo E信息，所述算法作为响应，为所述患者产生饮食和治疗计划。

    Method For Identifying At Risk Cardiovascular Disease Patients
    2.
    发明申请
    Method For Identifying At Risk Cardiovascular Disease Patients 审中-公开
    识别风险心血管疾病患者的方法

    公开(公告)号：US20090188796A1

    公开(公告)日：2009-07-30

    申请号：US12197694

    申请日：2008-08-25

    Applicant: David Shewmake ,  Frank Ruderman ,  Christopher Boggess ,  Faith Clendenen

    Inventor： David Shewmake ,  Frank Ruderman ,  Christopher Boggess ,  Faith Clendenen

    IPC: G01N27/447

    CPC classification number: G01N33/92 ,  C25B1/285 ,  G01N2800/32 ,  G01N2800/52 ,  Y10T436/104165

    Abstract: The invention provides a data base of LDL, I, IIa, IIb, IIIa, IIb, IVa, IVb and HDL2a, HDL2b, HDL 3a, HDL 3b and HDL 3c together with patient data such as HDL-C, LDL-C, Apo A, ApoB, Lp(a) and patient personal data useful for treatment, diagnosing, and monitoring cardiovascular disease. The data base contains the LDL and HDL subfraction data in quantitative mg/dl values and permits deriving relationship amongst the LDL and HDL values and cardiovascular disease. Quantitative data permits more effective treatment and monitoring of cardiovascular disease. For example, quantitative differences in LDL and HDL subclass levels can determine the need for more or less aggressive treatment. The data base which includes patient events, procedures, interventions which is correlated to LDL and HDl quantitative subclass data permits development of personalized patient treatment plans and monitoring the effectiveness of such treatment. Thus, LDL and HDL quantitative subfraction data can be used to more effectively treat and monitor cardiovascular disease.The invention, for example, provides a method for identifying patients with normal NCEP lipid levels who are in need of treatment for cardiovascular disease comprising measuring one or more LDL or HDL particle subclass levels and identifying abnormal LDL or HDL subclass levels. LDL III a & b and HDL 2b are preferred subclasses.

    Abstract translation: 本发明提供LDL，I，IIa，IIb，IIIa，IIb，IVa，IVb和HDL2a，HDL2b，HDL 3a，HDL 3b和HDL 3c的数据库以及患者数据如HDL-C，LDL-C，Apo A，ApoB，Lp（a）和患者个人资料可用于治疗，诊断和监测心血管疾病。 数据库包含定量mg / dl值中的LDL和HDL次级分数据，并允许LDL和HDL值与心血管疾病之间的关系。 定量数据可以更有效地治疗和监测心血管疾病。 例如，LDL和HDL亚类水平的定量差异可以确定对或多或少积极治疗的需要。 包括与LDL和HDI定量亚类数据相关的患者事件，程序，干预措施的数据库允许开发个性化的患者治疗计划并监测此类治疗的有效性。 因此，LDL和HDL定量分数据可用于更有效地治疗和监测心血管疾病。 例如，本发明提供了一种用于鉴定需要治疗心血管疾病的正常NCEP脂质水平的患者的方法，包括测量一种或多种LDL或HDL颗粒亚类水平并鉴定异常的LDL或HDL亚类水平。 LDL III a＆b和HDL 2b是优选的亚类。

    Method for quantitatively determining the LDL particle number in a distribution of LDL cholesterol subfractions
    5.
    发明申请
    Method for quantitatively determining the LDL particle number in a distribution of LDL cholesterol subfractions 审中-公开
    定量测定低密度脂蛋白胆固醇分数分布中LDL粒子数的方法

    公开(公告)号：US20070072302A1

    公开(公告)日：2007-03-29

    申请号：US11522591

    申请日：2006-09-18

    Applicant: Faith Clendenen ,  Christopher Boggess ,  Frank Ruderman

    Inventor： Faith Clendenen ,  Christopher Boggess ,  Frank Ruderman

    IPC: G01N33/92

    CPC classification number: G01N33/92

    Abstract: The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a LDL subfraction. The method features the steps of: 1) measuring an initial distribution of LDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of LDL particles with a mathematical model to determine a modified distribution of LDL particles (e.g., a relative particle distribution); 3) determining a total LDL particle number value from a blood sample; and 4) analyzing both the modified distribution of particles and the total LDL particle number value to calculate the particle number value in an LDL subfraction.

    Abstract translation: 本发明提供了一种用于计算LDL子分数中的粒子数量的方法（例如，计算机算法）。 该方法的特征在于：1）测量来自血液样本的LDL颗粒的初始分布（例如相对质量分布）; 2）用数学模型处理LDL颗粒的初始分布，以确定LDL颗粒的修饰分布（例如，相对颗粒分布）; 3）从血液样品中确定总LDL颗粒数值; 和4）分析改性粒子分布和总LDL粒子数值，以计算LDL亚分数中的粒子数值。

    Monitoring device for measuring calorie expenditure
    7.
    发明申请
    Monitoring device for measuring calorie expenditure 审中-公开
    用于测量卡路里消耗的监测装置

    公开(公告)号：US20070073178A1

    公开(公告)日：2007-03-29

    申请号：US11522565

    申请日：2006-09-18

    Applicant: Ray Browning ,  Christopher Hall ,  Matthew Banet

    Inventor： Ray Browning ,  Christopher Hall ,  Matthew Banet

    IPC: A61B5/04

    CPC classification number: A61B5/002 ,  A61B5/0022 ,  A61B5/024 ,  A61B5/11 ,  G16H40/67

    Abstract: The invention provides a monitoring device that features: 1) a cardiac sensor component with at least one light-emitting diode and a photodetector; 2) a pedometer component with at least one motion-sensing component (e.g., an accelerometer); and 3) a wireless component with a wireless interface that communicates with an external weight scale. The device also features a microprocessor in electrical communication with the cardiac sensor, pedometer, and wireless components and configured to analyze: 1) a signal from the cardiac sensor component to generate heart rate information; 2) a signal from the pedometer component to generate exercise information; 3) heart rate and exercise information to generate calorie information; and 4) a signal from the external weight scale to calculate weight information (e.g., weight and percent body fat).

    Abstract translation: 本发明提供了一种监测装置，其特征在于：1）具有至少一个发光二极管和光电检测器的心脏传感器部件; 2）具有至少一个运动感测部件（例如，加速度计）的计步器部件; 以及3）具有与外部重量秤通信的无线接口的无线部件。 该装置还具有与心脏传感器，计步器和无线部件电通信的微处理器，并且被配置为分析：1）来自心脏传感器部件的信号以产生心率信息; 2）来自计步器组件的信号以产生运动信息; 3）心率和运动信息产生卡路里信息; 和4）来自外部重量级的信号以计算重量信息（例如体重和身体脂肪百分比）。

    Method for identifying patients who will require multiple invasive cardiovascular procedures
    8.
    发明申请
    Method for identifying patients who will require multiple invasive cardiovascular procedures 审中-公开
    确定需要多次侵入性心血管手术的患者的方法

    公开(公告)号：US20040043496A1

    公开(公告)日：2004-03-04

    申请号：US10463664

    申请日：2003-06-16

    Applicant: Berkeley HeartLab, Inc.

    Inventor： H. Robert Superko

    IPC: G01N033/92

    CPC classification number: G01N33/92 ,  G01N2800/52

    Abstract: The invention provides a method for identifying patients who will require multiple invasive cardiac procedures comprising measuring elevated LDL IVb levels in patients who have had or will have invasive heart surgery.

    Abstract translation: 本发明提供了一种用于鉴定需要多次侵入性心脏手术的患者的方法，包括测量已经或将要进行侵入性心脏手术的患者的升高的LDL IVb水平。

    Cardiovascular healthcare management system and method
    9.
    发明授权
    Cardiovascular healthcare management system and method 有权
    心血管医疗管理系统及方法

    公开(公告)号：US07647234B1

    公开(公告)日：2010-01-12

    申请号：US09534946

    申请日：2000-03-24

    Applicant: Frank R. Ruderman ,  David T. Shewmake

    Inventor： Frank R. Ruderman ,  David T. Shewmake

    IPC: G06Q50/00

    CPC classification number: G06F19/3456 ,  G06F19/00 ,  G06F19/325 ,  G06F19/326 ,  G06F19/3418 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  Y10S706/924

    Abstract: The disclosure relates to an interactive, web based cardiovascular healthcare management system which has an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular education materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and/or patient treatment plan compliance data.

    Abstract translation: 本公开涉及一种基于互联网的心血管健康管理系统，其具有信息站点，其具有数据库，其具有与心血管疾病危险因素有关的信息，例如年龄，血压，LDL，HDL及其分数，以及心血管疾病管理，例如饮食，运动 药物和心血管教育材料。 医师可以与信息网站进行电子通信，以获得患者测试结果，并从饮食，运动和药物数据中制定患者治疗计划。 医生可以通过信息网站的记录将治疗计划电子化地传达给病人。 患者可以通过患者记录将合规信息以电子方式传达给医师。 信息网站还可以提供病例管理者向医师提供初始治疗计划草案，收集患者病史数据和/或患者治疗计划合规性数据。

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