公开(公告)号：US20080161848A1

公开(公告)日：2008-07-03

申请号：US11784310

申请日：2007-04-06

申请人： John S. Fisher

发明人： John S. Fisher

IPC分类号： A61B17/03

CPC分类号： A61L24/0042 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61L24/0015 ,  A61L24/0031 ,  A61L31/18 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/44 ,  A61L2300/604

摘要： A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.

摘要翻译： 由具有药物递送能力的可生物降解的聚合物形成的组织标记物与封装组织标记物的密封剂组合，并且其用于帮助锚定组织标记物抵抗迁移。 密封剂被递送到脱水形式的部位，并且在该部位组织中固有的水分使密封剂膨胀。 膨胀的密封剂由水凝胶形成，因此与组织标记的材料相比，与周围组织更相容。 密封剂和组织标记物随时间生物吸收。

公开(公告)号：US07329414B2

公开(公告)日：2008-02-12

申请号：US10063620

申请日：2002-05-03

申请人： John S. Fisher ,  Frederick Ahari ,  Lucjan J. J. Hronowski

发明人： John S. Fisher ,  Frederick Ahari ,  Lucjan J. J. Hronowski

IPC分类号： A61F2/02 ,  A61K51/02

CPC分类号： A61L24/0042 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61L24/0015 ,  A61L24/0031 ,  A61L31/18 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/44 ,  A61L2300/604

摘要： A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.

摘要翻译： 由具有药物递送能力的可生物降解的聚合物形成的组织标记物与封装组织标记物的密封剂组合，并且其用于帮助锚定组织标记物抵抗迁移。 密封剂被递送到脱水形式的部位，并且在该部位组织中固有的水分使密封剂膨胀。 膨胀的密封剂由水凝胶形成，因此与组织标记的材料相比，与周围组织更相容。 密封剂和组织标记物随时间生物吸收。

公开(公告)号：US07001410B2

公开(公告)日：2006-02-21

申请号：US10249263

申请日：2003-03-27

申请人： John S. Fisher ,  Frederick Ahari ,  Lucjan J. J. Hronowski

发明人： John S. Fisher ,  Frederick Ahari ,  Lucjan J. J. Hronowski

IPC分类号： A61B17/04

CPC分类号： A61B17/0644 ,  A61B17/0057 ,  A61B17/064 ,  A61B2017/00004 ,  A61B2017/00575 ,  A61B2017/00601

摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.

公开(公告)号：US06994712B1

公开(公告)日：2006-02-07

申请号：US10065704

申请日：2002-11-12

申请人： John S. Fisher ,  Frederick Ahari

发明人： John S. Fisher ,  Frederick Ahari

IPC分类号： A61B19/00

CPC分类号： A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/3987

摘要： A clip and a bioabsorbable marker are employed to mark a biopsy site. The former provides a permanent marker that is clamped onto tissue and that cannot migrate from the site over time. The latter is gradually bioabsorbed over time but the time may vary widely from weeks to months. In most embodiments, the clip and marker are integrally formed with one another at the time of manufacture. In one embodiment, the clip and marker are independently made but are joined to one another during the site-marking process. The markers are deployed by core biopsy needles of the type employing a vacuum, of the type that does not employ a vacuum, and by coaxial biopsy needles.

摘要翻译： 使用夹子和生物可吸收标记来标记活检部位。 前者提供了一个永久标记，夹在组织上，不能随时间从现场迁移。 后者随着时间的推移逐渐生物吸收，但时间可能会在几周到几个月不等。 在大多数实施例中，夹子和标记在制造时彼此一体形成。 在一个实施例中，夹子和标记器是独立制造的，但在位置标记过程期间彼此连接。 标记物由使用不使用真空的类型的真空的类型的核心活检针和同轴活检针部署。

公开(公告)号：US06908440B2

公开(公告)日：2005-06-21

申请号：US10708711

申请日：2004-03-19

申请人： John S. Fisher

发明人： John S. Fisher

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B10/04

CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04

摘要： A biopsy needle scrapes tissue of cellular size from a lesion during repeated proximal-to-distal thrusts of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge also scrapes tissue during proximal-to-distal travel of the needle. The second sharp edge may be coincident with an exterior surface of the needle, elevated with respect to the exterior surface, or recessed with respect to the exterior surface. Another embodiment includes a hinge for enabling pivotal movement of the second sharp edge.

摘要翻译： 活检针沿着其纵向对称轴在针的重复近端 - 远端推力期间从损伤处刮去细胞大小的组织。 由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。 第二锋利边缘由靠近第一锋利边缘的针中形成的横向设置的狭槽提供。 第二锋利的边缘也在针的近端到远端行进期间刮擦组织。 第二锋利边缘可以与针的外表面重合，相对于外表面升高或相对于外表面凹陷。 另一个实施例包括用于实现第二锋利边缘的枢转运动的铰链。

公开(公告)号：US20080091120A1

公开(公告)日：2008-04-17

申请号：US11954842

申请日：2007-12-12

申请人： John Fisher

发明人： John Fisher

IPC分类号： A61B10/02

CPC分类号： A61L24/0042 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61L24/0015 ,  A61L24/0031 ,  A61L31/18 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/44 ,  A61L2300/604

摘要： A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.

摘要翻译： 由具有药物递送能力的可生物降解的聚合物形成的组织标记物与封装组织标记物的密封剂组合，并且其用于帮助锚定组织标记物抵抗迁移。 密封剂被递送到脱水形式的部位，并且在该部位组织中固有的水分使密封剂膨胀。 膨胀的密封剂由水凝胶形成，因此与组织标记的材料相比，与周围组织更相容。 密封剂和组织标记物随时间生物吸收。

公开(公告)号：US06890309B2

公开(公告)日：2005-05-10

申请号：US10708712

申请日：2004-03-19

申请人： John S. Fisher

发明人： John S. Fisher

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B10/04

CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04

摘要： A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during forward and rearward reciprocations of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge scrapes tissue during distal-to-proximal travel of the needle. In a first embodiment, the second sharp edge is coincident with an exterior surface of the needle. In a second embodiment, the second sharp edge is elevated with respect to the exterior surface and in a third embodiment the second sharp edge is recessed. Additional embodiments include a second slot, a channel, and a hinge for enabling pivotal movement of the second and third sharp edges.

摘要翻译： 双针活检针在针沿其纵向对称轴的向前和向后往复运动期间从损伤处刮去细胞厚度的组织。 由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。 第二锋利边缘由靠近第一锋利边缘的针中形成的横向设置的狭槽提供。 第二个锋利的边缘在针的远端到近端行进期间刮擦组织。 在第一实施例中，第二锋利边缘与针的外表面重合。 在第二实施例中，第二锋利边缘相对于外表面升高，在第三实施例中，第二锋利边缘是凹进的。 另外的实施例包括用于使得第二和第三锋利边缘能够枢转运动的第二槽，通道和铰链。

公开(公告)号：US20050090765A1

公开(公告)日：2005-04-28

申请号：US10905599

申请日：2005-01-12

申请人： John Fisher

发明人： John Fisher

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B10/04

CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04

摘要： A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during proximal-to-distal travel of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A transversely disposed slot formed in the needle near the first sharp edge provides a second sharp edge. A bottom of the slot is proximal to the opening of the slot. The second sharp edge also scrapes tissue during proximal-to-distal travel of the needle. The second sharp edge is coincident with an exterior surface of the needle. A vacuum pulls the scraped cellular material into the lumen of the needle.

摘要翻译： 双针活检针在针沿其纵向对称轴的近端到远端行进期间从损伤处刮去细胞厚度的组织。 由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。 在第一锋利边缘附近形成在针中的横向设置的槽提供第二锋利边缘。 槽的底部靠近槽的开口。 第二锋利的边缘也在针的近端到远端行进期间刮擦组织。 第二锋利边缘与针的外表面重合。 真空将刮擦的细胞材料拉到针的内腔中。

公开(公告)号：US20040167435A1

公开(公告)日：2004-08-26

申请号：US10708712

申请日：2004-03-19

申请人： BIOPSY SCIENCES, LLC

发明人： John S. Fisher

IPC分类号： A61B010/00

CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04

摘要： A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during forward and rearward reciprocations of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge scrapes tissue during distal-to-proximal travel of the needle. In a first embodiment, the second sharp edge is coincident with an exterior surface of the needle. In a second embodiment, the second sharp edge is elevated with respect to the exterior surface and in a third embodiment the second sharp edge is recessed. Additional embodiments include a second slot, a channel, and a hinge for enabling pivotal movement of the second and third sharp edges.

摘要翻译： 双针活检针在针沿其纵向对称轴的向前和向后往复运动期间从损伤处刮去细胞厚度的组织。 由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。 第二锋利边缘由靠近第一锋利边缘的针中形成的横向设置的狭槽提供。 第二个锋利的边缘在针的远端到近端行进期间刮擦组织。 在第一实施例中，第二锋利边缘与针的外表面重合。 在第二实施例中，第二锋利边缘相对于外表面升高，在第三实施例中，第二锋利边缘是凹进的。 另外的实施例包括用于使得第二和第三锋利边缘能够枢转运动的第二槽，通道和铰链。

公开(公告)号：US20040167434A1

公开(公告)日：2004-08-26

申请号：US10708711

申请日：2004-03-19

申请人： BIOPSY SCIENCES, LLC

发明人： John S. Fisher

IPC分类号： A61B010/00

CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04

摘要： A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during forward and rearward reciprocations of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge scrapes tissue during distal-to-proximal travel of the needle. In a first embodiment, the second sharp edge is coincident with an exterior surface of the needle. In a second embodiment, the second sharp edge is elevated with respect to the exterior surface and in a third embodiment the second sharp edge is recessed. Additional embodiments include a second slot, a channel, and a hinge for enabling pivotal movement of the second and third sharp edges.

摘要翻译： 双针活检针在针沿其纵向对称轴的向前和向后往复运动期间从损伤处刮去细胞厚度的组织。 由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。 第二锋利边缘由靠近第一锋利边缘的针中形成的横向设置的狭槽提供。 第二个锋利的边缘在针的远端到近端行进期间刮擦组织。 在第一实施例中，第二锋利边缘与针的外表面重合。 在第二实施例中，第二锋利边缘相对于外表面升高，在第三实施例中，第二锋利边缘是凹进的。 另外的实施例包括用于使得第二和第三锋利边缘能够枢转运动的第二槽，通道和铰链。