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1.发明授权公开(公告)号：US08658632B2
公开(公告)日：2014-02-25
申请号：US13481333
申请日：2012-05-25
申请人： Lane Brostrom , John R. Falck
发明人： Lane Brostrom , John R. Falck
IPC分类号： C07C231/02 , A61P25/04 , A61K31/16
CPC分类号： C07C233/09 , C07C237/22 , C07C275/20 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
摘要翻译： 本发明提供花生四烯酸（AA）类似物和含有这些类似物作为止痛治疗活性剂的组合物。 提供了制备本发明化合物的各种方法，并描述了药物制剂，包括可注射和口服剂量。 某些类似物另外可用作解热组合物和相关的发烧减少治疗。
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公开(公告)号：US11951083B2
公开(公告)日：2024-04-09
申请号：US17867352
申请日：2022-07-18
申请人： Cytometix, Inc.
发明人： John R. Falck , Lane Brostrom
CPC分类号： A61K31/16 , A61K9/127 , A61K47/10 , A61K47/24 , A61K47/28 , C07C231/14 , C07B2200/13 , C07C2601/02
摘要： Systems, compositions, and methods are disclosed for developing and delivering therapeutically effective 14,15-epoxyeicosatrienoic acid (14,15-EET) analogs, for example for pain management or treatment. Of particular interest are intermediate salts.
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公开(公告)号：US20220387357A1
公开(公告)日：2022-12-08
申请号：US17730375
申请日：2022-04-27
申请人： Cytometix, Inc.
发明人： Lane Brostrom
摘要： A method for minimizing tachycardia in a subject treated for pain and experiencing tachycardia after being treated with the compound having the structure: An effective amount of the compound is administered to a subject, where the effective amount treats pain and minimizes tachycardia in said subject experiencing tachycardia after being administered said compound.
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4.发明公开公开(公告)号：US20230398086A1
公开(公告)日：2023-12-14
申请号：US17867352
申请日：2022-07-18
申请人： Cytometix, Inc.
发明人： John R. Falck , Lane Brostrom
CPC分类号： A61K31/16 , C07C231/14 , A61K9/127 , A61K47/24 , A61K47/28 , A61K47/10 , C07B2200/13 , C07C2601/02
摘要： Systems, compositions, and methods are disclosed for developing and delivering therapeutically effective 14,15-epoxyeicosatrienoic acid (14,15-EET) analogs, for example for pain management or treatment. Of particular interest are intermediate salts.
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5.发明申请公开(公告)号：US20140135401A1
公开(公告)日：2014-05-15
申请号：US14158064
申请日：2014-01-17
申请人： Lane Brostrom , John R. Falck
发明人： Lane Brostrom , John R. Falck
IPC分类号： C07C233/09
CPC分类号： C07C233/09 , C07C237/22 , C07C275/20 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
摘要翻译： 本发明提供花生四烯酸（AA）类似物和含有这些类似物作为止痛治疗活性剂的组合物。 提供了制备本发明化合物的各种方法，并描述了药物制剂，包括可注射和口服剂量。 某些类似物另外可用作解热组合物和相关的发烧减少治疗。
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公开(公告)号：US20060247200A1
公开(公告)日：2006-11-02
申请号：US11414896
申请日：2006-05-01
申请人： David Harder , James Antczak , Lane Brostrom
发明人： David Harder , James Antczak , Lane Brostrom
IPC分类号： A61K48/00 , A61K31/7076 , A61K38/44
CPC分类号： A61K38/44 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B4 (LTB4) in those in need of such treatment using LTB4 hydroxylases. In certain embodiments, LTB4 hydroxylase is administered in combination with nicotinamide adenine dinucleotide phosphate and/or an NADPH-cytochrome P-450 reductase. The invention is particularly useful for treating or preventing respiratory diseases that are caused or exacerbated by inflammation.
摘要翻译： 描述了用于治疗或预防人类或非人类动物疾病的方法和用途，通过减少需要这些的那些活性白细胞三烯B 4（LTB 4 N 4）的量 使用LTB 4 羟化酶的治疗。 在某些实施方案中，LTB 4羟化酶与烟酰胺腺嘌呤二核苷酸磷酸酯和/或NADPH-细胞色素P-450还原酶组合施用。 本发明特别可用于治疗或预防炎症引起或加重的呼吸系统疾病。
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7.发明授权公开(公告)号：US10966937B2
公开(公告)日：2021-04-06
申请号：US15571314
申请日：2016-05-03
申请人： Cytometix, Inc.
IPC分类号： A61K45/06 , A61K9/48 , A61K31/202 , A61P29/00 , A61K31/05 , A61K31/164 , A61K31/4468 , A61K31/381 , A61K31/135 , A61K31/16 , A61K31/197
摘要： The present invention provides a system enabling the oral delivery of therapeutics derived from polyunsaturated fatty acids (PUFAs), their metabolites and derivatives, including, eicosanoids, prostaglandins, prostacyclins, leukotrienes, resolvins, endocannabinoids, thromboxanes, epoxyeicosa-trienoic acids (EETs), hydroxyeicostetraenoic acids (HETEs), and CMX-020. The delivery system includes a vehicle comprising a purified docosahexaenoic acid (DHA) in triglyceride or ester form; a purified eicosapentaenoic acid (EPA) in triglyceride or ester form; a combination of DHA, EPA in either triglyceride or ester forms; or a modified DHA, EPA, or omega-3 fatty acid analog; and optionally, an antioxidant, a surfactant, a solubilizer, a stabilizer, a lubricant, or a pH/tonicity adjustment agent.
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8.发明授权公开(公告)号：US09096494B2
公开(公告)日：2015-08-04
申请号：US14158064
申请日：2014-01-17
申请人： Cytometix, Inc.
发明人： Lane Brostrom , John R. Falck
IPC分类号： C07C233/09 , C07C237/22 , C07C275/20
CPC分类号： C07C233/09 , C07C237/22 , C07C275/20 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
摘要翻译： 本发明提供花生四烯酸（AA）类似物和含有这些类似物作为止痛治疗活性剂的组合物。 提供了制备本发明化合物的各种方法，并描述了药物制剂，包括可注射和口服剂量。 某些类似物另外可用作解热组合物和相关的发烧减少治疗。
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9.发明申请公开(公告)号：US20130023510A1
公开(公告)日：2013-01-24
申请号：US13481333
申请日：2012-05-25
申请人： Lane Brostrom , John R. Falck
发明人： Lane Brostrom , John R. Falck
IPC分类号： A61K31/16 , C07C233/27 , A61K31/167 , C07C275/22 , A61K31/17 , A61P25/04 , C07D203/18 , A61K31/396 , C07C233/20 , C07C231/02 , A61P29/00 , C07C233/10 , C07C233/09
CPC分类号： C07C233/09 , C07C237/22 , C07C275/20 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
摘要翻译： 本发明提供花生四烯酸（AA）类似物和含有这些类似物作为止痛治疗活性剂的组合物。 提供了制备本发明化合物的各种方法，并描述了药物制剂，包括可注射和口服剂量。 某些类似物另外可用作解热组合物和相关的发烧减少治疗。
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