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公开(公告)号：US11628297B2
公开(公告)日：2023-04-18
申请号：US16745265
申请日：2020-01-16
摘要： A biomedical device having improved handling features to be easily inserted into a cavity or recess is disclosed, as well as methods for using thereof, said device comprising a flat and soft substrate, comprising electrically conductive tracks, configured to interface a biological surface; and a rigid member located on a portion of said flat and soft substrate, said member being substantially composed of a mechanically adaptive material being fully or partially degradable upon a degrading/softening trigger.
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公开(公告)号：US11615285B2
公开(公告)日：2023-03-28
申请号：US15864146
申请日：2018-01-08
发明人： Michael Wolfgang Reimann , Max Christian Nolte , Henry Markram , Kathryn Pamela Hess Bellwald , Ran Levi
摘要： In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph includes identifying a directed functional edge of the functional subgraph based on presence of structural connection and directional communication of information across the same structural connection.
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公开(公告)号：US20230026586A1
公开(公告)日：2023-01-26
申请号：US17783690
申请日：2021-01-27
摘要： The invention discloses systems and methods for generation of microfluidic jets providing a tool for very precise and localized delivery of e.g., medicaments. The proposed solution overcomes shortcomings related to miniaturization of a jet injection technology by implementing laser energy as a driving mechanism and optical fibers for its delivery. Solving the step of miniaturization can allow building new tools compatible with minimally invasive surgical techniques, high parallelization of jet injection units or design of new ergonomic injection devices.
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公开(公告)号：US20220380930A1
公开(公告)日：2022-12-01
申请号：US17876161
申请日：2022-07-28
发明人： Jiandong FENG , Ke LIU , Aleksandra RADENOVIC , Yann ASTIER
IPC分类号： C25F3/12 , B23H9/14 , B23H7/20 , G01N33/487 , G01N27/414 , C12Q1/6869 , C25F7/00 , G01N27/447
摘要： The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.
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公开(公告)号：US20220370564A1
公开(公告)日：2022-11-24
申请号：US17760947
申请日：2020-09-18
发明人： Yugang GUO , Li TANG , Yu-Qing XIE
摘要： The present disclosure relates to new agents useful for anti-cancer therapy such as anti-cancer adoptive T-cell transfer (ACT) immunotherapy or immune check-point blockade therapy and related compositions, uses and methods thereof.
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公开(公告)号：US20220333154A1
公开(公告)日：2022-10-20
申请号：US17858628
申请日：2022-07-06
摘要： Glucose sensors comprising a mutated biomolecule immobilised to a substrate are disclosed. The biomolecule is glucose oxidase, concanavalin A, or glucose binding protein. The mutated biomolecule is immobilised to the substrate via a linker comprising a thiol reactive group and a substrate adherence group. The biomolecule is mutated to introduce one or more surface accessible thiol moieties. The mutated biomolecule is connected to the linker via the one or more surface accessible thiol moieties on the biomolecule and the thiol reactive group on the linker.
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公开(公告)号：US20220315979A1
公开(公告)日：2022-10-06
申请号：US17620343
申请日：2020-06-16
摘要： Sensors comprising B-L-S; wherein: B is a biomolecule comprising one or more surface-exposed thiol moieties, L is a thiol reactive linking group, and S is a substrate; wherein L is covalently linked to B via the one or more surface-exposed thiol moieties.
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公开(公告)号：US20220307878A1
公开(公告)日：2022-09-29
申请号：US17638654
申请日：2020-08-26
发明人： Fabien SORIN , William ESPOSITO , Véronique MICHAUD , Chaoqun DONG , Baris ÇAGLAR , Dang Tung NGUYEN
摘要： The present invention concerns an elongated capacitive sensor for fluid monitoring. The sensor comprising: a fibre support made of a dielectric material or dielectric composite material; and a first electrode and a second electrode arranged longitudinally along the fibre support, the first and second electrodes forming together with the fibre support a capacitive sensing element whose capacitance is dependent upon one or more electrical properties of one or more materials inside the support and/or outside the support, and/or is dependent upon a change of materials configuration and associated overall change of one or more electrical properties inside the support and/or outside the support.
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公开(公告)号：US20220275533A1
公开(公告)日：2022-09-01
申请号：US17263352
申请日：2019-07-26
发明人： Niels QUACK , Sichen MI , Teodoro GRAZIOSI , Adrien TOROS
IPC分类号： C30B33/12 , H01J37/305 , C30B29/04
摘要： Polishing method comprising the steps of: —providing at least one crystalline layer or substrate, the at least one crystalline layer or substrate extending in at least one plane, and including at least one outer surface and at least one depression extending from the at least one outer surface; and —polishing the at least one outer surface using ion beam etching (IBE) or an accelerated inert gas ion beam, the ion beam being incident on the at least one outer surface at non-normal incidence or at a non-zero angle (θ) with respect to the surface normal of the at least one plane of the crystalline layer or substrate.
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公开(公告)号：US20220199673A1
公开(公告)日：2022-06-23
申请号：US17262409
申请日：2018-07-24
发明人： Assim Boukhayma
IPC分类号： H01L27/146
摘要： The present invention relates to a multispectral image sensor having a pixel array for detecting images with light components in different wave-length ranges, comprising a plurality of imaging layers each embedded in a semiconductor substrate, wherein in each of the imaging layers an array of photodetecting regions is provided, wherein the photodetecting regions are configured with different absorption characteristics, wherein the imaging layers are stacked so that the photodetecting regions of the arrays are aligned, wherein the absorption characteristics allow a preferred absorption of light components of at least one predetermined wavelength range.
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