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    Methods for detecting enveloped virus infections by measuring cell surface TSG101
    1.
    发明授权
    Methods for detecting enveloped virus infections by measuring cell surface TSG101 失效
    通过测量细胞表面TSG101检测包膜病毒感染的方法

    公开(公告)号：US08476009B2

    公开(公告)日：2013-07-02

    申请号：US12190802

    申请日：2008-08-13

    申请人： Limin Li

    发明人： Limin Li

    IPC分类号： C12Q1/70 ,  C07K16/00

    CPC分类号： C07K16/1045 ,  A61K2039/505 ,  C07K16/1081 ,  C07K16/32 ,  Y02A50/386 ,  Y02A50/466

    摘要： The invention involves the detection of virally infected cells by antibodies or antibody fragments which selectively bind to TSG101. TSG101 is on the surface of mammalian cells, and thus available for detection by antibodies, during viral budding—a phenomenon wherein viral particles escape a virally infected cell after propagation in that cell, so as to infect other cells. To achieve budding, a protein, TSG101 is “hijacked” and misdirected to, or mis-expressed on, the surface of the infected cell. Antibodies can be used to selectively detect such infected cells. Certain TSG101 antibodies may provide therapeutic benefit when administered to infected mammals.

    摘要翻译： 本发明涉及通过选择性结合TSG101的抗体或抗体片段检测病毒感染的细胞。 TSG101位于哺乳动物细胞的表面，因此可用于在病毒出芽期间被抗体检测，这种现象是病毒颗粒在该细胞繁殖后逃离病毒感染的细胞，从而感染其他细胞。 为了实现萌芽，一种蛋白质，TSG101被“劫持”，并被误导或者被感染细胞表面的错误表达。 可以使用抗体来选择性地检测这样的感染细胞。 当被感染的哺乳动物施用时，某些TSG101抗体可以提供治疗益处。

    Random homozygous gene perturbation to enhance antibody production
    2.
    发明授权
    Random homozygous gene perturbation to enhance antibody production 有权
    随机纯合基因扰动以增强抗体产生

    公开(公告)号：US08361792B2

    公开(公告)日：2013-01-29

    申请号：US12777417

    申请日：2010-05-11

    申请人： Roxanne Duan ,  Michael Goldblatt

    发明人： Roxanne Duan ,  Michael Goldblatt

    IPC分类号： C12N5/07

    CPC分类号： C07K16/00

    摘要： The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.

    摘要翻译： 本发明反映了通过随机纯合基因扰动方法转化的细胞系增强或减少除感兴趣抗体之外的细胞系的基因的表达模式的目标抗体的增强的抗体表达。 与通过RHGP转化之前与抗体表达细胞系亲本相比，转化细胞系表现出1.5GP以上RHGP转化细胞留置量的比生产率SPR。 可以设计敲除或反义构建体以减少靶基因的表达，启动子可以被插入以增强靶基因的表达。 由转化的细胞系表达的抗体在用RHGP转化之前表现出其亲本细胞系的结合特性，并且增加所述细胞在给定体积中的所述抗体的总体积产量。

    ANTIBODIES FOR DIAGNOSIS AND THERAPEUTIC TREATMENT OF PROSTATE CANCER
    3.
    发明申请
    ANTIBODIES FOR DIAGNOSIS AND THERAPEUTIC TREATMENT OF PROSTATE CANCER 审中-公开
    用于诊断和治疗前列腺癌的抗体

    公开(公告)号：US20110206695A1

    公开(公告)日：2011-08-25

    申请号：US13013002

    申请日：2011-01-25

    申请人： Manu Kohli ,  Michael Goldblatt ,  Michael Kinch

    发明人： Manu Kohli ,  Michael Goldblatt ,  Michael Kinch

    IPC分类号： A61K39/395 ,  C12Q1/70 ,  A61P35/00

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/28 ,  G01N33/57434 ,  G01N2333/15

    摘要： XMRV appears to be related to both prostate cancer if it infects a male germ cell and chronic fatigue syndrome in both sexes. (If the virus does not infect a germ cell). Prostate cancer cells exhibit TSG101 on the surface only upon infection with a virus like XMRV. Antibodies to TSG101 can be effective diagnostics to identify individuals with a predisposition to prostate. They can also be used in place of current diagnostics to confirm the presence of prostate cancer. TSG101 antibodies, when administered in vivo, exhibit the ability to reduce tumor size, suppress metastatic transformation and extend survival.

    摘要翻译： XMRV似乎与前列腺癌相关，如果它感染男性生殖细胞和慢性疲劳综合征两性。 （如果病毒不感染生殖细胞）。 前列腺癌细胞只有在感染了像XMRV这样的病毒时才在表面上显示TSG101。 对TSG101的抗体可以有效地诊断以鉴别具有前列腺炎倾向的个体。 它们也可以用于代替目前的诊断以确认前列腺癌的存在。 TSG101抗体在体内施用时，具有减少肿瘤大小，抑制转移转化和延长存活的能力。

    ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS
    7.
    发明申请
    ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS 失效
    ANTI-TSG101抗体及其用于治疗病毒感染的用途

    公开(公告)号：US20090196874A1

    公开(公告)日：2009-08-06

    申请号：US12190802

    申请日：2008-08-13

    申请人： Limin LI

    发明人： Limin LI

    IPC分类号： A61K39/395 ,  G01N33/53 ,  A61K39/00 ,  A61P31/18 ,  A61P31/12

    CPC分类号： C07K16/1045 ,  A61K2039/505 ,  C07K16/1081 ,  C07K16/32 ,  Y02A50/386 ,  Y02A50/466

    摘要： The invention involves the detection of virally infected cells by antibodies or antibody fragments which selectively bind to TSG101. TSG101 is on the surface of mammalian cells, and thus available for detection by antibodies, during viral budding—a phenomenon wherein viral particles escape a virally infected cell after propagation in that cell, so as to infect other cells. To achieve budding, a protein, TSG101 is “hijacked” and misdirected to, or mis-expressed on, the surface of the infected cell. Antibodies can be used to selectively detect such infected cells. Certain TSG101 antibodies may provide therapeutic benefit when administered to infected mammals.

    摘要翻译： 本发明涉及通过选择性结合TSG101的抗体或抗体片段检测病毒感染的细胞。 TSG101位于哺乳动物细胞的表面，因此可用于在病毒出芽期间被抗体检测，这种现象是病毒颗粒在该细胞繁殖后逃离病毒感染的细胞，从而感染其他细胞。 为了实现萌芽，一种蛋白质，TSG101被“劫持”，并被误导或者被感染细胞表面的错误表达。 可以使用抗体来选择性地检测这样的感染细胞。 当被感染的哺乳动物施用时，某些TSG101抗体可以提供治疗益处。