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    OPTICAL DETERMINATION OF PH AND GLUCOSE
    1.
    发明申请
    OPTICAL DETERMINATION OF PH AND GLUCOSE 有权
    PH和葡萄糖的光学测定

    公开(公告)号：US20140058225A1

    公开(公告)日：2014-02-27

    申请号：US13951125

    申请日：2013-07-25

    申请人： GluMetrics, Inc

    发明人： David R. Markle ,  Jeff T. Suri ,  Ritchie A. Wessling ,  Matthew A. Romey

    IPC分类号： A61B5/145 ,  A61B5/1459

    CPC分类号： A61B5/14532 ,  A61B5/1451 ,  A61B5/14539 ,  A61B5/1459 ,  G01N33/66 ,  G01N33/84 ,  G01N2400/00

    摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

    摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例测定pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。

    Sensor for percutaneous intravascular deployment without an indwelling cannula
    2.
    发明授权
    Sensor for percutaneous intravascular deployment without an indwelling cannula 有权
    用于经皮血管内部署的传感器，无需留置插管

    公开(公告)号：US08512245B2

    公开(公告)日：2013-08-20

    申请号：US12424902

    申请日：2009-04-16

    申请人： David R. Markle ,  William H. Markle

    发明人： David R. Markle ,  William H. Markle

    IPC分类号： A61B5/1459 ,  A61B5/145 ,  A61B17/34

    CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14542 ,  A61M25/0668

    摘要： The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue.

    摘要翻译： 本发明涉及一种用于经皮插入和没有留置插管的血管内存活的传感器。 在优选实施例中，使用可移除的套管将葡萄糖传感器插入血管。 在插管被移除之后，葡萄糖传感器本身保持在血管内并与患者的组织形成密封。

    Optical sensor configuration for ratiometric correction of blood glucose measurement
    3.
    发明授权
    Optical sensor configuration for ratiometric correction of blood glucose measurement 有权
    血糖测量比例校正的光学传感器配置

    公开(公告)号：US08467843B2

    公开(公告)日：2013-06-18

    申请号：US12612602

    申请日：2009-11-04

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0238 ,  A61B2562/043 ,  G01N21/7703 ,  G01N2021/7786

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于检测血糖的光学传感器。 该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端和无损伤尖端部分之间的间隙内，其中光纤和无创尖端部分通过耦合部件耦合，例如杆或海波管或笼， 差距。 传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL
    4.
    发明申请
    USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL 有权
    使用平均血管内传感器实现轻度控制

    公开(公告)号：US20120116191A1

    公开(公告)日：2012-05-10

    申请号：US13316397

    申请日：2011-12-09

    申请人： William H. Markle ,  David R. Markle

    发明人： William H. Markle ,  David R. Markle

    IPC分类号： A61B5/1459

    CPC分类号： A61B5/14532 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/412 ,  A61M5/16827 ,  A61M5/1723

    摘要： A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.

    摘要翻译： 公开了一种在有需要的患者中实现紧密血糖控制的方法。 该方法包括将平衡葡萄糖传感器布置在患者的血管内，将传感器耦合到显示血糖浓度的监测器，以及当血糖浓度在预定浓度范围之外变化时施用血糖调节剂。 以足以将血糖浓度返回到预定浓度范围内的量施用血糖调节剂，由此实现严格的血糖控制。

    MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION
    5.
    发明申请
    MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION 有权
    用于测量分析温度和PH校正的分析仪浓度的测量装置和方法

    公开(公告)号：US20110224516A1

    公开(公告)日：2011-09-15

    申请号：US13046571

    申请日：2011-03-11

    申请人： Matthew A. Romey ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： Matthew A. Romey ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/1455 ,  A61B5/145

    CPC分类号： G06F17/00 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0247 ,  A61B2560/0252 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2021/7793

    摘要： Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.

    摘要翻译： 本文公开了估计分析物浓度的方法，其包括产生指示分析物浓度的信号，产生指示温度的信号，产生指示pH的信号，并且使用下述方程式转化表示分析物浓度的信号： 取决于Michaelis-Menten参数的修改的Michaelis-Menten方程的形式，其中根据包括温度和pH校准参数，指示温度的信号和指示pH的信号的数据来设置Michaelis-Menten参数的值 。 本文还公开了采用上述方法的测量装置。

    DRY INSERTION AND ONE-POINT IN VIVO CALIBRATION OF AN OPTICAL ANALYTE SENSOR
    7.
    发明申请
    DRY INSERTION AND ONE-POINT IN VIVO CALIBRATION OF AN OPTICAL ANALYTE SENSOR 有权
    光学分析仪传感器的体积校准中的干插入和一点

    公开(公告)号：US20140128694A1

    公开(公告)日：2014-05-08

    申请号：US14073661

    申请日：2013-11-06

    申请人： Glumetrics, Inc.

    发明人： Stuart L. Gallant ,  William H. Markle ,  Mano Goharla'ee

    IPC分类号： A61B5/145 ,  A61B5/1455

    CPC分类号： A61B5/14532 ,  A61B5/14539 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/1495 ,  A61B2562/043 ,  A61B2562/223

    摘要： Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.

    摘要翻译： 公开了涉及将包括光纤的葡萄糖传感器部署到生理流体中的实施方案，其中光纤沿着其远端区域设置有包含固定在水凝胶内的荧光团和葡萄糖结合部分的化学指示剂系统，其中 化学指示器系统的部件在部署前处于干燥状态。 还公开了基于独立测量的葡萄糖浓度的化学指示剂系统的一点体内校准。

    DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR
    8.
    发明申请
    DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR 审中-公开
    光学分析传感器的部署系统和方法

    公开(公告)号：US20110263953A1

    公开(公告)日：2011-10-27

    申请号：US13095748

    申请日：2011-04-27

    申请人： David R. Markle ,  Soya Gamsey ,  Kenneth J. Chesnin

    发明人： David R. Markle ,  Soya Gamsey ,  Kenneth J. Chesnin

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/1491 ,  A61B5/1495 ,  A61B2560/0252 ,  A61B2560/06

    摘要： Embodiments of the invention are directed to a delivery device and method for deploying an optical analyte sensor. The delivery device comprises hollow tubes configured to operate telescopically. The optical sensor is configured to retract and extend from a distal end of the delivery device, by sliding the telescoping tubes with respect to one another. The delivery device may also have a locking mechanism such that the distal end portion of the sensor will extend to a preset locked position beyond the delivery device, e.g., during calibration and deployment. The device is capable of being used to ship, calibrate, and deploy the sensor while maintaining sterility and avoiding exposure to the external environment.

    摘要翻译： 本发明的实施例涉及用于部署光学分析物传感器的递送装置和方法。 输送装置包括构造成可伸缩地操作的中空管。 光学传感器被配置为通过相对于彼此滑动伸缩管而从输送装置的远端缩回和延伸。 输送装置还可以具有锁定机构，使得传感器的远端部分例如在校准和展开期间将延伸到超出输送装置的预设锁定位置。 该设备能够用于运输，校准和部署传感器，同时保持无菌状态，避免暴露在外部环境中。