公开(公告)号：US12014491B2

公开(公告)日：2024-06-18

申请号：US17271651

申请日：2019-08-28

申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Ron Kimmel ,  Benjamin Groisser ,  Alon Wolf ,  Roger F. Widmann ,  Howard J. Hillstrom

IPC分类号： G06T7/00 ,  A61B6/00 ,  G06T7/246 ,  G06T7/38 ,  G06T11/00

CPC分类号： G06T7/0012 ,  A61B6/4411 ,  A61B6/527 ,  G06T7/246 ,  G06T7/38 ,  G06T11/006 ,  G06T2207/10028 ,  G06T2207/10084 ,  G06T2207/20201 ,  G06T2207/30012 ,  G06T2211/408

摘要： A method comprising: receiving a radiographic image dataset representing a sequential radiographic scan of a region of a human subject; receiving three-dimensional (3D) image data representing an optical scan of a surface of said region, wherein said 3D image data is performed simultaneously with said sequential radiographic scan; estimating a time-dependent motion of said subject during said acquisition, relative to a specified position, based, at least in part, on said 3D image data; and using said estimating to determine corrections for said radiographic image dataset, based, at least in part, on a known transformation between corresponding coordinate systems of said radiographic image dataset and said 3D image data.

公开(公告)号：US11660044B2

公开(公告)日：2023-05-30

申请号：US16884511

申请日：2020-05-27

申请人： New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special Surgery

发明人： Carl Imhauser

IPC分类号： A61B5/00

CPC分类号： A61B5/4585 ,  A61B5/6835

摘要： An apparatus for evaluating motions of a joint is provided that is designed for determining stability of an anatomical joint. The apparatus includes a support frame, a fixation assembly for securing a first body segment of a joint, and a displacement assembly mounted to the support frame. The fixation assembly includes an axis of rotation moveable relative to the support frame. The displacement assembly includes a first frame pivotably mounted to the support frame and rotatably connected to a first end of the fixation assembly, and a second frame pivotably mounted to the support frame and rotatably connected to a second end of the fixation assembly.

公开(公告)号：US11147829B2

公开(公告)日：2021-10-19

申请号：US16523055

申请日：2019-07-26

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Alessandra Pernis ,  Michela Manni

IPC分类号： A61K48/00 ,  C07H21/04 ,  A61K31/7105 ,  C07K16/30 ,  C12N15/113 ,  A61P5/48 ,  A61P35/00

摘要： This current invention provides methods and agents for preventing and treating autoimmune and lymphoproliferative disease by targeting pathogenic age-associated B cells as well as methods of detecting these pathogenic age-associated B cells as a method of diagnosing and predicting autoimmune disease and other lymphoproliferative and chronic inflammatory disorders.
The current invention also provides targets for drug development and basic research for autoimmune diseases and other lymphoproliferative and chronic inflammatory disorders.

公开(公告)号：US20210178118A1

公开(公告)日：2021-06-17

申请号：US17185453

申请日：2021-02-25

申请人： Hospital for Special Surgery

发明人： Stavros Memtsoudis

IPC分类号： A61M25/00 ,  A61M5/168 ,  A61M39/02 ,  A61M5/158

摘要： A multi-catheter infusion system and method for the localized delivery of medications while minimally affecting patient mobility for an extended period of time. The multi-catheter infusion system includes a cannula and a plurality of catheters. The cannula includes a first end for connecting to a drug delivery system and a second end for connecting to the plurality of catheters. The plurality of catheters are in fluid communication with the cannula for delivering a drug to a target area of a patient. Each catheter includes a multi-orifice distal end.

公开(公告)号：US20210128540A1

公开(公告)日：2021-05-06

申请号：US16625164

申请日：2018-06-23

申请人： New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery

发明人： Chitra DAHIA

IPC分类号： A61K31/4436 ,  A61K45/06 ,  A61P21/00

摘要： Presented herein are methods for treating spinal disc degeneration (SDD) by administering to a subject in need thereof, an amount of a SHE signaling pathway activator effective for treating the subject.

公开(公告)号：US10750979B2

公开(公告)日：2020-08-25

申请号：US15404986

申请日：2017-01-12

申请人： Hospital for Special Surgery

发明人： Carl Imhauser ,  Brendan Dugan ,  Jeffrey Kinsberg

IPC分类号： A61B5/00 ,  A61B5/11

摘要： An apparatus for determining 3D load displacement characteristics of an anatomical joint formed by a first body portion and a second body portion moveable with respect to the first body portion. The apparatus includes a first frame for receiving and securing the first body portion and a load displacement assembly. The load displacement assembly includes a first axis for alignment with a first anatomical plane of the joint, a second frame for receiving and securing the second body portion. The second frame is movable relative to the first frame. The load displacement assembly also includes a first counterweight configured to balance the weight of the second frame, a force for applying a load to the second frame, and a displacement sensor for measuring displacement of the second frame relative to the first frame upon application of the force.

公开(公告)号：US10314575B2

公开(公告)日：2019-06-11

申请号：US15235413

申请日：2016-08-12

申请人： Hospital for Special Surgery

发明人： William Rodriguez ,  Riley J. Williams

IPC分类号： A61B17/06 ,  A61B17/04 ,  A61B17/00 ,  A61F2/08 ,  A61B90/92

摘要： A suture fixation device and method thereof is provided. The suture fixation device includes a suture fiber having a length of about 24 to 40 inches and a plurality of knots spaced apart from each other along the length of the suture fiber. Each of the plurality of knots has an overall width of about 3.0 to 4.0 mm.

公开(公告)号：US10024844B2

公开(公告)日：2018-07-17

申请号：US14654139

申请日：2013-12-20

申请人： Hospital for Special Surgery ,  University Health Network

发明人： Carl Blobel ,  Thorsten Maretzky ,  David McIlwain ,  Tak Wah Mak

IPC分类号： G01N33/48 ,  G01N33/50 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113 ,  A61K39/00

摘要： Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that decreases the biological activity of iRhom1 and an effective amount of an agent (“Second Agent”) that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent (“Second Agent”) that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.

公开(公告)号：US20170361063A1

公开(公告)日：2017-12-21

申请号：US15536348

申请日：2015-12-21

申请人： Hospital for Special Surgery

发明人： Stavros Memtsoudis

IPC分类号： A61M25/00 ,  A61M5/158 ,  A61M25/06 ,  A61M25/02 ,  A61M25/04

CPC分类号： A61M25/0026 ,  A61M5/158 ,  A61M5/16804 ,  A61M25/0084 ,  A61M25/04 ,  A61M25/065 ,  A61M39/0247 ,  A61M2025/0286 ,  A61M2039/0264 ,  A61M2039/0282 ,  A61M2205/3331

摘要： A multi-catheter infusion system and method for the localized delivery of medications while minimally affecting patient mobility for an extended period of time. The multi-catheter infusion system includes a cannula and a plurality of catheters. The cannula includes a first end for connecting to a drug delivery system and a second end for connecting to the plurality of catheters. The plurality of catheters are in fluid communication with the cannula for delivering a drug to a target area of a patient. Each catheter includes a multi-orifice distal end.

公开(公告)号：US09579106B2

公开(公告)日：2017-02-28

申请号：US13075378

申请日：2011-03-30

申请人： Darrick Lo ,  Joseph Lipman ,  Andrew D. Pearle

发明人： Darrick Lo ,  Joseph Lipman ,  Andrew D. Pearle

IPC分类号： A61B17/56 ,  A61B17/15 ,  A61B17/17

CPC分类号： A61B17/15 ,  A61B17/1778 ,  A61B2017/568 ,  A61B2034/108

摘要： Patient specific shoulder component implant instruments are described for hemi and total, normal and reverse shoulder arthroplasty.

摘要翻译： 描述患者特殊的肩部组件植入器械用于半身和全身，正常和反向肩关节置换术。