公开(公告)号：US20120220657A1

公开(公告)日：2012-08-30

申请号：US13463278

申请日：2012-05-03

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

IPC分类号： A61K31/56 ,  A61P9/00 ,  A61P25/16 ,  A61P35/00 ,  A61P25/28

CPC分类号： A61K31/19 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/12 ,  A61K2300/00 ,  A23V2200/306 ,  A23V2200/312 ,  A23V2200/314 ,  A23V2200/32 ,  A23V2200/308 ,  A23V2200/326 ,  A23V2250/21 ,  A23V2250/2112 ,  A23V2250/308 ,  A23V2200/02 ,  A23V2250/2132 ,  A23V2250/212

摘要： Disclosed herein are novel dietary supplement compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid and enriched demethylated curcuminoids, wherein the composition exhibits anti-inflammatory, antiulcerogenic and anti-oxidant activities. Also disclosed are novel compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid, enriched demethylated curcuminoids that have a synergistic effect on specific inhibition of—COX-2 and 5-LOX activity and optionally containing glucosamine, resveratrol, garlic extract, chondroitin, methlysulphonymethane, bromelain, serratiopeptidase, quercitine, gallic acid, caffeic acid, green tea extract, aspirin and ibuprofen.

摘要翻译： 本文公开了包含富含3-O-乙酰基-11-酮基 - 谷氨酸和富集的去甲基化姜黄素的新型膳食补充剂组合物，其中所述组合物表现出抗炎，抗溃疡和抗氧化活性。 还公开了包含富集的3-O-乙酰基-11-酮基 - 谷氨酸的富集的去甲基化姜黄素的新型组合物，其对COX-2和5-LOX活性的特异性抑制具有协同作用，并且任选地含有葡糖胺，白藜芦醇 ，大蒜提取物，软骨素，甲基磺酰甲烷，菠萝蛋白酶，丝氨酸肽酶，槲皮素，没食子酸，咖啡酸，绿茶提取物，阿司匹林和布洛芬。

公开(公告)号：US20100098676A1

公开(公告)日：2010-04-22

申请号：US12593581

申请日：2007-04-03

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Vendateswarlu somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Vendateswarlu somepalli

IPC分类号： A61K38/43 ,  A61K31/192 ,  A61K31/70 ,  A61K36/254 ,  A61K36/82 ,  A61K31/60 ,  A61P9/00 ,  A61P29/00 ,  A61P25/28

CPC分类号： A61K31/19 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/12 ,  A61K2300/00 ,  A23V2200/306 ,  A23V2200/312 ,  A23V2200/314 ,  A23V2200/32 ,  A23V2200/308 ,  A23V2200/326 ,  A23V2250/21 ,  A23V2250/2112 ,  A23V2250/308 ,  A23V2200/02 ,  A23V2250/2132 ,  A23V2250/212

摘要： Disclosed herein are novel dietary supplement compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid and enriched demethylated curcuminoids, wherein the composition exhibits anti-inflammatory, antiulcerogenic and antioxidant activities. Also disclosed are novel compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid, enriched demethylated curcuminoids that have a synergistic effect on specific inhibition of—COX-2 and 5-LOX activity and optionally containing glucosamine, resveratrol, garlic extract, chondroitin, methlysulphonymethane, bromelain, serratiopeptidase, quercitine, gallic acid, caffeic acid, green tea extract, aspirin and ibuprofen.

摘要翻译： 本发明公开了包含富含3-O-乙酰基-11-酮基 - 谷氨酸和富集的去甲基化姜黄素的新型膳食补充剂组合物，其中所述组合物表现出抗炎，抗癌和抗氧化活性。 还公开了包含富集的3-O-乙酰基-11-酮基 - 谷氨酸的富集的去甲基化姜黄素的新型组合物，其对COX-2和5-LOX活性的特异性抑制具有协同作用，并且任选地含有葡糖胺，白藜芦醇 ，大蒜提取物，软骨素，甲基磺酰甲烷，菠萝蛋白酶，丝氨酸肽酶，槲皮素，没食子酸，咖啡酸，绿茶提取物，阿司匹林和布洛芬。

公开(公告)号：US08226989B2

公开(公告)日：2012-07-24

申请号：US12477643

申请日：2009-06-03

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Golakoti Trimurtulu ,  Sivaramakrishna Chillara ,  Krishanu Sengupta ,  Kiran Bhupathiraju

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Golakoti Trimurtulu ,  Sivaramakrishna Chillara ,  Krishanu Sengupta ,  Kiran Bhupathiraju

IPC分类号： A61K36/00

CPC分类号： A61K45/06 ,  A61K36/324 ,  A61K36/38 ,  A61K36/75 ,  A61K36/9068 ,  A61K2300/00

摘要： Herbal compositions having anti-adipocyte fatty acid-binding protein (aP2), anti-5-lipoxygenase-activating protein (FLAP) and anti-Cysteinyl Leukotriene (CysLT)-1 receptor expression activity contain an extract of Boswellia serrata. More particularly, these herbal compositions comprise an effective amount of an enriched Boswellia extract containing from 10% to 99% by weight of 3-0-acetyl-11-keto-β-boswellic acid; and an effective amount of a second extract selected from the group consisting of an extract of Aegle marmelos, an extract of Zingiber officinale, an extract of Garcinia mangostana, and mixtures thereof. These may be used in dietary supplements or pharmaceutical formulations for controlling diseases associated with or related to inflammation. These diseases in particular include respiratory disorders such as asthma, allergic rhinitis, hay fever, type-1 hypersensitivity and mild allergies. The compositions can also be useful for skin care.

摘要翻译： 具有抗脂肪细胞脂肪酸结合蛋白（aP2），抗5-脂氧合酶活化蛋白（FLAP）和抗半胱氨酰白三烯（CysLT）-1受体表达活性的草药组合物含有乳香乳杆菌的提取物。 更具体地说，这些草药组合物包含有效量的含有10％至99％（重量）3-0-乙酰基-11-酮基 - 半乳糖酸的富集的乳香提取物; 和有效量的选自Aegle marmelos的提取物，Zingiber officinale的提取物，Garcinia mangostana的提取物及其混合物的第二提取物。 这些可以用于饮食补充剂或药物制剂中，用于控制与炎症相关或与炎症有关的疾病。 这些疾病特别包括呼吸系统疾病如哮喘，过敏性鼻炎，花粉症，1型超敏反应和轻度过敏。 组合物也可用于皮肤护理。

公开(公告)号：US07741370B2

公开(公告)日：2010-06-22

申请号：US10541828

申请日：2004-04-19

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

IPC分类号： A61K31/19 ,  C07C59/245 ,  C07C59/265

CPC分类号： C07F3/003 ,  C07C59/285

摘要： This invention relates to new double salts of (−)-hydroxycitric acid with group II metals. Preferred double salts are calcium and magnesium double salts of hydroxycitric acid of the formula II. This invention also includes a process for the preparation of these double salts by the addition of one metal compound from group II to (−)-hydroxycitric acid solution followed by the addition of other metal compound solution from group II. These double salts are tasteless and are soluble in water. They are useful as dietary supplements and in beverages.

摘要翻译： 本发明涉及（ - ） - 羟基柠檬酸与II族金属的新的双重盐。 优选的双盐是式II的羟基柠檬酸的钙和镁复合盐。 本发明还包括通过将II族金属化合物加入到（ - ） - 羟基柠檬酸溶液中，然后从II组中加入其它金属化合物溶液来制备这些双重盐的方法。 这些双盐是无味的，可溶于水。 它们作为膳食补充剂和饮料是有用的。

公开(公告)号：US06900356B2

公开(公告)日：2005-05-31

申请号：US10333971

申请日：2001-04-18

申请人： Ganga Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

IPC分类号： C07C45/67 ,  C07C45/74 ,  C07C49/248 ,  C07C49/255 ,  C09K15/08 ,  C07C45/71 ,  C07C39/12

CPC分类号： C09K15/08 ,  C07C45/673 ,  C07C45/74 ,  C07C49/248 ,  C07C49/255

摘要： This invention relates to novel polyhydroxy curcumins of the formula (I), wherein R and R1 may be same or different and are selected from H, OH and OCH3. This invention also includes a process for synthesising the above polyhydroxy curcumins by reacting substituted aromatic alhehydes with a diketone in the presence of boron oxide, alkyl borate and a primary or secondary amine catalyst. If desired, the resulting compounds can be deprotected by known means. These compounds are used as anti-oxidants.

摘要翻译： 本发明涉及式（I）的新型多羟基姜黄素，其中R和R 1可以相同或不同，并且选自H，OH和OCH 3。 本发明还包括通过在硼氧烷，硼酸烷基酯和伯胺或仲胺催化剂存在下使取代的芳族醛与二酮反应来合成上述多羟基姜黄素的方法。 如果需要，所得化合物可以通过已知方法去保护。 这些化合物用作抗氧化剂。

公开(公告)号：US11122829B2

公开(公告)日：2021-09-21

申请号：US16196896

申请日：2018-11-20

申请人： LAILA IMPEX

发明人： Ganga Raju Gokaraju ,  Trimurtulu Golakoti ,  Rama Raju Gokaraju ,  Kiran Bhupathiraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/00 ,  A23L33/105 ,  A61K36/482 ,  A61K36/22 ,  A61K36/185 ,  A61K36/48 ,  A23L2/52 ,  A61P21/00 ,  A61K36/28 ,  A61K36/74

摘要： The invention discloses novel dietary supplements or herbal product comprising at least one ingredient selected from the extracts or fractions derived from Bauhinia racemosa fruit, Cassia auriculata, Mangifera indica stem bark, Woodfordia fruticosa tender stem and Acacia nilotica fruit or their compositions in combination with at least one compound selected from biological actives, herbal extracts, minerals, amino acids, proteins, vitamins, excipient, diluent or carrier as a natural energy enhancer to provide an onset and steady maintenance of energy and for improving muscle strength, muscle mass and mental alertness, for treating sarcopenia and muscular atrophy in a warm blooded animal or mammal in need thereof.

公开(公告)号：US08568802B2

公开(公告)日：2013-10-29

申请号：US12083105

申请日：2005-10-13

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Venkateswarlu Somepalli

IPC分类号： A61K36/9066 ,  A61K36/00

CPC分类号： C07C45/62 ,  A01N65/00 ,  A01N65/48 ,  A61K36/9066 ,  C07C45/673 ,  C07C45/78 ,  C07C45/79 ,  C07C45/81 ,  A01N2300/00 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255

摘要： A process for producing an enriched fraction of tetrahydoxycurcumin containing, tetrahydroxycurcumin, demethylcurcumin, demethylmonodemethoxycurcumin and bisd.emethoxycurcumin and colorless tetrahydroderivatives thereof. The process consists of demethylation of natural curcumins, obtained, in turn, from the organic solvent extract of turmeric from Curcuma species. The said enriched fraction of tetrahydroxycurcumin is subjected to hydrogenation to get colorless tetrahydrotetrahydroxycurcumin enriched fraction. The enriched fractions of tetrahydroxycurcumin and colorless tetrahydrotetrahydroxycurcumin exhibits potent antioxidative action and reduces inflammation.

摘要翻译： 制备含有四羟基姜黄素，去甲基姜黄素，去甲基一甲氧基姜黄素和双二甲氧基姜黄素及其无色四氢衍生物的四氢氧基姜黄素的富集级分的方法。 该方法由天然姜黄素的去甲基化组成，其又从姜黄的有机溶剂提取物中获得。 将所述富集级分的四羟基姜黄素进行氢化，得到无色四氢四羟基半胱氨酸富集馏分。 四羟基姜黄素和无色四氢四羟基姜黄素的富集部分表现出有效的抗氧化作用并减少炎症。

公开(公告)号：US08524769B2

公开(公告)日：2013-09-03

申请号：US10432058

申请日：2002-03-05

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Sridhar Pratha

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Sridhar Pratha

IPC分类号： A61K31/21

CPC分类号： C07J63/008

摘要： The invention relates to a process for producing a fraction enriched upto 100% of 3-O-acetyl-11-keto-β-boswellic acid. An organic solvent extract of gum resin from Boswellia species is first subjected to oxidation and then acetylation or vice versa. This converts the less potent boswellic acids present in the fraction to AKBA. This treated fraction is subjected to further purification and separation by chromatographic separation techniques to enhance its purity and to remove contaminants therefrom. This process provide an access to a fraction enriched in 10-100% AKBA for therapeutic applications.

摘要翻译： 本发明涉及一种生产高达100％的3-O-乙酰基-11-酮-β-乳糖酸的级分的方法。 首先将来自Boswellia物种的树胶的有机溶剂提取物进行氧化，然后进行乙酰化反应，反之亦然。 这将该部分中存在的较不有效的保乳酸转化为AKBA。 通过色谱分离技术对经处理的级分进行进一步纯化和分离，以提高其纯度并从中除去污染物。 该方法提供了获得用于治疗应用的富含10-100％AKBA的级分。

公开(公告)号：US08192768B2

公开(公告)日：2012-06-05

申请号：US12593581

申请日：2007-04-03

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Vendateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Vendateswarlu Somepalli

IPC分类号： A61K36/00 ,  A61K36/82

CPC分类号： A61K31/19 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/12 ,  A61K2300/00 ,  A23V2200/306 ,  A23V2200/312 ,  A23V2200/314 ,  A23V2200/32 ,  A23V2200/308 ,  A23V2200/326 ,  A23V2250/21 ,  A23V2250/2112 ,  A23V2250/308 ,  A23V2200/02 ,  A23V2250/2132 ,  A23V2250/212

摘要： Disclosed herein are novel dietary supplement compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid and enriched demethylated curcuminoids, wherein the composition exhibits anti-inflammatory, antiulcerogenic and antioxidant activities. Also disclosed are novel compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid, enriched demethylated curcuminoids that have a synergistic effect on specific inhibition of—COX-2 and 5-LOX activity and optionally containing glucosamine, resveratrol, garlic extract, chondroitin, methlysulphonymethane, bromelain, serratiopeptidase, quercitine, gallic acid, caffeic acid, green tea extract, aspirin and ibuprofen.

摘要翻译： 本发明公开了包含富含3-O-乙酰基-11-酮基 - 谷氨酸和富集的去甲基化姜黄素的新型膳食补充剂组合物，其中所述组合物表现出抗炎，抗癌和抗氧化活性。 还公开了包含富集的3-O-乙酰基-11-酮基 - 谷氨酸的富集的去甲基化姜黄素的新型组合物，其对COX-2和5-LOX活性的特异性抑制具有协同作用，并且任选地含有葡糖胺，白藜芦醇 ，大蒜提取物，软骨素，甲基磺酰甲烷，菠萝蛋白酶，丝氨酸肽酶，槲皮素，没食子酸，咖啡酸，绿茶提取物，阿司匹林和布洛芬。

公开(公告)号：US08541381B2

公开(公告)日：2013-09-24

申请号：US11813778

申请日：2005-05-03

申请人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukkala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

发明人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukkala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

IPC分类号： A61K31/70 ,  A61K31/7028 ,  C07H17/00

CPC分类号： A61K36/80

摘要： This invention describes a process for producing a fraction enriched with jujubogenin and psudojujubogenin lycosides from Bacopa species, wherein the total Bacopa saponin concentration is up to 100% when estimated by HPLC method of analysis. The present invention also describes the processes for the enrichment of new compositions and individual saponin compounds from Bacopa monnieri to more than 95% purity. It further describes an analytical HPLC method for the estimation of total Bacopa saponin fraction and its use in therapeutic applications. This invention also includes two Bacopa saponin 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] jujubogenin and 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] pseudojujubogenin herein referred to as bacopaside N1 of general formula (1) and bacopaside N2 of general formula (2) respectively.

摘要翻译： 本发明描述了从Bacopa物种生产富集jujubogenin和psudojujubogenin lycosides的级分的方法，其中当通过HPLC分析方法估计时，总Bacopa皂苷浓度高达100％。 本发明还描述了从Bacopa monnieri中将新组合物和单独皂苷化合物富集至95％以上纯度的方法。 它进一步描述了用于估计总Bacopa皂角苷级分的分析型HPLC方法及其在治疗应用中的用途。 本发明还包括两种Bacopa皂角苷3-O-β-D-吡喃葡萄糖基 - （1-> 3）-β-D-吡喃葡萄糖基] jujubogenin和3-O- [β-D-吡喃葡萄糖基 - （1-> 3） β-D-吡喃葡萄糖基]假胡椒素原，本文中分别称为通式（1）的杆菌肽N1和通式（2）的杆菌肽N2。