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1.发明授权Structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties 有权具有抗糖尿病和抗炎特性的科罗索酸的结构类似物公开(公告)号：US07893263B2
公开(公告)日：2011-02-22
申请号：US10543387
申请日：2004-07-08
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli , Venkateswara Rao Chirravuri
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli , Venkateswara Rao Chirravuri
IPC分类号： C07C45/00 , C07C47/00 , C07C233/00 , C07C235/00 , C07D211/78 , C07D211/90 , C07D241/04 , C07D295/00
CPC分类号： C07J63/008 , C07C229/08 , C07C233/58 , C07C233/60 , C07C233/62 , C07C235/40 , C07C235/82 , C07C2603/52 , C07D213/80 , C07D313/06 , C07D327/10
摘要： This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compounds are also within the scope of this invention.
摘要翻译： 本发明涉及式I的新型科罗索酸类似物，其中本文描述了R1，R2，R3，R4和R5。 这些化合物表现出良好的降血糖和5-脂氧合酶抑制活性。 它们也抑制肿瘤生长。 含有已知副产物和标题化合物的药物组合物也在本发明的范围内。
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2.发明申请NOVEL SALTS OF BOSWELLIC ACIDS AND SELECTIVELY ENRICHED BOSWELLIC ACIDS AND PROCESSES FOR THE SAME 审中-公开硼酸盐和选择性硼酸盐的新型盐及其相容方法公开(公告)号：US20090042832A1
公开(公告)日：2009-02-12
申请号：US11817946
申请日：2005-03-07
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A61K31/715 , C07H3/00 , C07C59/82 , A61K31/19
CPC分类号： C07J63/008
摘要： New salts or ion pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.
摘要翻译： 通过一种新的获得的硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物 改进的方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。
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公开(公告)号：US08541383B2
公开(公告)日：2013-09-24
申请号：US12784295
申请日：2010-05-20
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswara Rao Chirravuri , Venkateswarlu Somepalli , Kiran Bhupathiraju
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswara Rao Chirravuri , Venkateswarlu Somepalli , Kiran Bhupathiraju
CPC分类号： A61Q19/06 , A61K8/602 , A61K8/97 , A61K36/185 , A61K36/75 , A61K36/9066 , A61K2800/782 , A61K2300/00
摘要： Synergistic anti-adipogenic and pro-lipolytic compositions for the prevention and amelioration of adipogenesis and lipolysis mediated diseases, comprising at least two extracts selected from enriched demethylated curcuminoids obtained from Curcuma longa, Moringa oleifera and Murraya koenigii. The anti-adipogenic and pro-lipolytic compositions optionally contain one or more anti-obesic agents. These compositions are useful for preventing anti-inflammatory and free radical mediated diseases.
摘要翻译： 用于预防和改善脂肪生成和脂肪分解介导的疾病的协同的抗脂肪生成和促脂肪分解组合物，其包含至少两种提取物，其选自从姜黄，甘草和Murraya koenigii获得的富集的去甲基化姜黄素。 抗脂肪生成和促脂解组合物任选地含有一种或多种抗痴呆剂。 这些组合物可用于预防抗炎和自由基介导的疾病。
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4.发明授权Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers 失效抗癌药物及其与转移性恶性黑色素瘤及其它癌症有关的用途公开(公告)号：US08258119B2
公开(公告)日：2012-09-04
申请号：US12559811
申请日：2009-09-15
申请人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli , Sengupta Krishanu , Kiran Bhupathiraju
发明人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli , Sengupta Krishanu , Kiran Bhupathiraju
IPC分类号： C07D333/38 , C07D495/04 , A61K31/655 , A61K31/53 , A61P35/00
CPC分类号： C07D333/38 , C07D333/40 , C07D495/04
摘要： The present invention discloses triazene analogs of the general formula (I) and formula (II), their tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts thereof for the metastatic malignant melanoma and other cancers including but not limited to lymphomas, sarcomas, carcinomas, and gliomas.The invention further discloses a process for the preparation of the above said triazene analogs of formula (I) and formula (II), and their pharmaceutically acceptable compositions.
摘要翻译： 本发明公开了通式（I）和式（II）的三氮烯类似物，其互变异构形式，立体异构体，多晶型物，水合物，溶剂合物和其药学上可接受的盐，用于转移性恶性黑素瘤和其它癌症，包括但不限于淋巴瘤 ，肉瘤，癌和胶质瘤。 本发明还公开了制备上述式（I）和式（II）的三氮烯类似物及其药学上可接受的组合物的方法。
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5.发明申请ANTI-CANCER DRUGS AND USES RELATING THERETO FOR METASTATIC MALIGNANT MELANOMA AND OTHER CANCERS 失效抗癌药物及其相关用途用于分离性恶性肿瘤和其他癌症公开(公告)号：US20100068178A1
公开(公告)日：2010-03-18
申请号：US12559811
申请日：2009-09-15
申请人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli , Sengupta Krishanu , Kiran Bhupathiraju
发明人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli , Sengupta Krishanu , Kiran Bhupathiraju
IPC分类号： A61K31/655 , C07C245/24 , A61K31/704 , A61K33/24 , A61K31/7048 , A61K31/7068 , A61K39/395 , A61K38/21 , A61K38/20 , A61P35/00
CPC分类号： C07D333/38 , C07D333/40 , C07D495/04
摘要： The present invention discloses triazene analogs of the general formula (I) and formula (II), their tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts thereof for the metastatic malignant melanoma and other cancers including but not limited to lymphomas, sarcomas, carcinomas, and gliomas.The invention further discloses a process for the preparation of the above said triazene analogs of formula (I) and formula (II), and their pharmaceutically acceptable compositions.
摘要翻译： 本发明公开了通式（I）和式（II）的三氮烯类似物，其互变异构形式，立体异构体，多晶型物，水合物，溶剂合物和其药学上可接受的盐，用于转移性恶性黑素瘤和其它癌症，包括但不限于淋巴瘤 ，肉瘤，癌和胶质瘤。 本发明还公开了制备上述式（I）和式（II）的三氮烯类似物及其药学上可接受的组合物的方法。
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6.发明申请公开(公告)号：US20120220657A1
公开(公告)日：2012-08-30
申请号：US13463278
申请日：2012-05-03
CPC分类号： A61K31/19 , A23L33/105 , A23V2002/00 , A61K31/12 , A61K2300/00 , A23V2200/306 , A23V2200/312 , A23V2200/314 , A23V2200/32 , A23V2200/308 , A23V2200/326 , A23V2250/21 , A23V2250/2112 , A23V2250/308 , A23V2200/02 , A23V2250/2132 , A23V2250/212
摘要： Disclosed herein are novel dietary supplement compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid and enriched demethylated curcuminoids, wherein the composition exhibits anti-inflammatory, antiulcerogenic and anti-oxidant activities. Also disclosed are novel compositions comprising enriched 3-O-acetyl-11-keto-β-boswellic acid, enriched demethylated curcuminoids that have a synergistic effect on specific inhibition of—COX-2 and 5-LOX activity and optionally containing glucosamine, resveratrol, garlic extract, chondroitin, methlysulphonymethane, bromelain, serratiopeptidase, quercitine, gallic acid, caffeic acid, green tea extract, aspirin and ibuprofen.
摘要翻译： 本文公开了包含富含3-O-乙酰基-11-酮基 - 谷氨酸和富集的去甲基化姜黄素的新型膳食补充剂组合物，其中所述组合物表现出抗炎，抗溃疡和抗氧化活性。 还公开了包含富集的3-O-乙酰基-11-酮基 - 谷氨酸的富集的去甲基化姜黄素的新型组合物，其对COX-2和5-LOX活性的特异性抑制具有协同作用，并且任选地含有葡糖胺，白藜芦醇 ，大蒜提取物，软骨素，甲基磺酰甲烷，菠萝蛋白酶，丝氨酸肽酶，槲皮素，没食子酸，咖啡酸，绿茶提取物，阿司匹林和布洛芬。
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7.发明授权Anti-cancer drugs, and uses relating for malignant melanoma and other cancers 有权抗癌药物，以及与恶性黑素瘤和其他癌症相关的用途公开(公告)号：US08143237B2
公开(公告)日：2012-03-27
申请号：US12767647
申请日：2010-04-26
申请人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Venkateswarlu Somepalli , Trimurtulu Golakoti , Kiran Bhupathiraju , Sengupta Krishanu , Venkata Krishna Raju Alluri
发明人： Ganga Raju Gokaraju , Sudhakar Kasina , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Venkateswarlu Somepalli , Trimurtulu Golakoti , Kiran Bhupathiraju , Sengupta Krishanu , Venkata Krishna Raju Alluri
IPC分类号： C07D517/04 , A61K31/53 , A61K31/655 , A61P31/00
CPC分类号： A61K31/655 , A61K38/193 , A61K38/20 , A61K38/21 , A61K45/06 , C07D253/04 , C07D517/14 , A61K2300/00
摘要： Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.
摘要翻译： 硒代苯三氮烯类似物，它们的组合物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物及其药学上可接受的盐和混合物可用于治疗转移性恶性黑素瘤和其它癌症。 硒代苯并三氮烯类似物具有通式（I）或（II）：其中取代基R 1，R 2，R 3，R 6和R 7如说明书中所述。 可以用这些化合物治疗的其它癌症包括但不限于恶性黑素瘤，白血病，淋巴瘤（霍奇金淋巴瘤和非霍奇金淋巴瘤），肉瘤（尤文氏肉瘤），脑肿瘤，中枢神经系统（CNS）转移瘤，胶质瘤 ，癌症如乳腺癌，前列腺癌，肺癌（小细胞和非小细胞），结肠癌，胰腺癌，头颈部癌症和口咽鳞状细胞癌。
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公开(公告)号：US20110112190A1
公开(公告)日：2011-05-12
申请号：US13002588
申请日：2009-07-06
申请人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A61K31/232 , C07C69/587 , C07C69/602 , C07C67/08 , A61P39/06 , A61P25/28
CPC分类号： C07C67/08 , C07C67/293 , C07C69/587
摘要： The invention discloses a compound of formula (I) wherein, at least one of R1, R2, R3 and R4 is —C(═O)Rn and R1, R2R3 and R4 are H or CH3 and Rn is alkyl or alkenyl group. The alkenyl group have one or more number of double bonds either in cis form or trans form or both. In Rn, where n is 12 to 30 carbons; and pharmaceutically acceptable salt thereof. The said alkenyl groups are preferably selected from the group consisting of eicosapentaenoic acid (EPA) or DHA (docosahexaenoic acid). This invention further discloses processes for their preparation of compounds of formula I and pharmaceutical compositions that contain these compounds.
摘要翻译： 本发明公开了式（I）化合物，其中R 1，R 2，R 3和R 4中的至少一个为-C（= O）R n，R 1，R 2 R 3和R 4为H或CH 3，R n为烷基或链烯基。 烯基具有一个或多个数量的以顺式或反式形式或两者的双键。 在Rn中，n为12至30个碳; 及其药学上可接受的盐。 所述烯基优选选自二十碳五烯酸（EPA）或DHA（二十二碳六烯酸）。 本发明还公开了其制备式I化合物的方法和含有这些化合物的药物组合物。
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公开(公告)号：US08680143B2
公开(公告)日：2014-03-25
申请号：US13002588
申请日：2009-07-06
申请人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A01N37/02 , A01N37/06 , A61K31/225
CPC分类号： C07C67/08 , C07C67/293 , C07C69/587
摘要： The invention discloses a compound of formula (I) wherein, at least one of R1, R2, R3 and R4 is —C(═O)Rn and R1, R2R3 and R4 are H or CH3 and Rn is alkyl or alkenyl group. The alkenyl group have one or more number of double bonds either in cis form or trans form or both. In Rn, where n is 12 to 30 carbons; and pharmaceutically acceptable salt thereof. The said alkenyl groups are preferably selected from the group consisting of eicosapentaenoic acid (EPA) or DHA (docosahexaenoic acid). This invention further discloses processes for their preparation of compounds of formula I and pharmaceutical compositions that contain these compounds.
摘要翻译： 本发明公开了式（I）化合物，其中R 1，R 2，R 3和R 4中的至少一个为-C（= O）R n，R 1，R 2 R 3和R 4为H或CH 3，R n为烷基或链烯基。 烯基具有一个或多个数量的以顺式或反式形式或两者的双键。 在Rn中，n为12至30个碳; 及其药学上可接受的盐。 所述烯基优选选自二十碳五烯酸（EPA）或DHA（二十二碳六烯酸）。 本发明还公开了其制备式I化合物的方法和含有这些化合物的药物组合物。
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10.发明申请Novel Salts Of Boswellic Acids And Selectively Enriched Boswellic Acids And Processes For The Same 审中-公开新型磺草酸和选择性富含乳香酸和过程的盐公开(公告)号：US20130116211A1
公开(公告)日：2013-05-09
申请号：US13724663
申请日：2012-12-21
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
CPC分类号： C07J63/008
摘要： New salts or ion-pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.
摘要翻译： 通过硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物通过 新的改进方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。
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