公开(公告)号：US20070086958A1

公开(公告)日：2007-04-19

申请号：US11580372

申请日：2006-10-13

申请人： James Drake ,  Ann Gronda

发明人： James Drake ,  Ann Gronda

IPC分类号： A61K9/14

CPC分类号： A61L26/008 ,  A61K9/10 ,  A61K9/14 ,  A61K9/7015 ,  A61L26/0052

摘要： Compositions and methods use the gel-forming properties of microporous particles to create useful formulations combining two free-flowing materials to produce a hydrogel mass. The free-flowing materials preferably provide dry microporous particles (preferably as an aerosol) that may contain additional agents, and a second composition of a fluid material which is an aqueous solution of one or more high molecular weight polymers capable of forming a hydrogel upon further concentration and/or reaction. The hydrogels can be preferably formed on a surface by spraying the two compositions as fluids together in the proper ratio onto the surface.

摘要翻译： 组合物和方法使用微孔颗粒的凝胶形成性质来产生组合两种自由流动材料以产生水凝胶团的有用配方。 自由流动的材料优选提供可以含有另外的试剂的干燥微孔颗粒（优选为气溶胶）和流体材料的第二组合物，其是一种或多种能够进一步形成水凝胶的高分子量聚合物的水溶液 浓度和/或反应。 优选通过将两种组合物作为流体以适当的比例喷射到表面上而在表面上形成水凝胶。

公开(公告)号：US07517355B2

公开(公告)日：2009-04-14

申请号：US11222444

申请日：2005-09-08

申请人： James Franklin Drake ,  Lynn R. Skow

发明人： James Franklin Drake ,  Lynn R. Skow

IPC分类号： A61B17/08 ,  A61D1/00

CPC分类号： B05B11/062 ,  A61L26/0023 ,  A61L26/0085 ,  B05B7/1413 ,  B05D1/28 ,  B05D2401/32 ,  C08L5/02

摘要： Masses of particles are structurally supported by the application of vacuum through a support surface having holes thereon that are smaller than the average diameter of the particle mass that is to be supported. The reduced pressure structurally supports particles on the support surface. The mass of particles tends is so well supported that it tends retain its shape unless additional forces are applied. The system comprises the vacuum applicator (e.g., pump), a vacuum carrying system and the support surface. When a mass of particles is supported on the support surface under vacuum, the particles can be carried to a target surface, the mass of particles pressed against the target surface, the mass conforming to the target surface, and the vacuum reduced or stopped, depositing the particle mass onto the surface in excellent shape compliance with that surface.

摘要翻译： 颗粒的质量在结构上通过在其上具有孔的支撑表面施加真空来支撑，该支撑表面小于待支撑的颗粒物质的平均直径。 减压结构上支撑在支撑表面上的颗粒。 颗粒的质量非常好地被支撑，除非施加额外的力，否则它倾向于保持其形状。 该系统包括真空施加器（例如泵），真空承载系统和支撑表面。 当颗粒物质在真空下支撑在支撑表面上时，颗粒可以被运送到目标表面，颗粒物质压在目标表面上，质量符合目标表面，真空减少或停止，沉积 表面上的颗粒质量与该表面良好的形状一致。

公开(公告)号：US20070087061A1

公开(公告)日：2007-04-19

申请号：US11580598

申请日：2006-10-13

申请人： James Drake ,  Ann Gronda

发明人： James Drake ,  Ann Gronda

IPC分类号： A61K35/14 ,  A61K31/715

CPC分类号： A61L26/0057 ,  A61K31/715 ,  A61K35/14 ,  A61K35/16 ,  A61K35/19 ,  A61L26/0023 ,  A61K2300/00 ,  C08L3/00

摘要： A composition, method, and use of microporous particles such as polysaccharide hemostat particle gels activates platelet rich plasma (PRP) or other platelet-containing substances. The composition may contain microporous polysaccharaide hemostats (MPH) mixed with platelet-rich plasma, platelet-poor plasma, blood, or the like. The method may contain mixing the MPH with platelet-rich plasma or other platelet-containing substance either by hand, in a device, or by applying the MPH directly to the wound before or after application of the platelet-containing substance. Alternatively, MPH can by applied directly to the bleeding wound, using the blood as a source of platelets.

摘要翻译： 多孔颗粒如多糖止血剂颗粒凝胶的组合物，方法和用途激活富血小板血浆（PRP）或其他含血小板的物质。 组合物可以含有与富含血小板的血浆，血小板血浆，血液等混合的微孔多糖止血剂（MPH）。 该方法可以包括在手部，装置中或通过在施用含血小板的物质之前或之后将MPH直接施加到伤口上来将MPH与富含血小板的血浆或其他含血小板的物质混合。 或者，MPH可以直接应用于出血伤口，使用血液作为血小板来源。