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公开(公告)号：US09018377B2
公开(公告)日：2015-04-28
申请号：US13386021
申请日：2010-07-22
IPC分类号： A61K31/44 , C07D221/04 , C07D471/06 , C07D471/16 , C07D221/14 , C07D401/12
CPC分类号： C07D221/14 , C07D401/12 , Y10T436/206664
摘要： The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q+ is an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q+. The invention also provides methods of detecting and determining the presence of analytes and/or hydrogen peroxide in a sample, as well as a substrate that comprises the compound of formula I.
摘要翻译： 本发明提供式I F-L-Q（I）的化合物，其中F包含能够在激发波长处吸收能量的荧光团，并且在不存在猝灭剂的情况下发射不同于激发波长的发射波长的能量; Q包括猝灭剂; L包含具有两个末端的连接部分，一端与F共价结合，另一端与Q共价结合。化合物能够经历可逆反应（1），其如下：（1）其中Q +是氧化的 形式Q表示不存在猝灭剂，Ox包含氧化剂，其能够将Q氧化成其氧化形式Q，并且Red包含还原剂，其能够将Q转化为其还原形式Q.化合物 当能量照射时，当Q以其氧化态存在时，可以进行光诱导电子转移。 本发明还提供了检测和确定样品中分析物和/或过氧化氢的存在以及包含式I化合物的底物的方法。
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公开(公告)号：US20070259444A1
公开(公告)日：2007-11-08
申请号：US11743576
申请日：2007-05-02
申请人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
发明人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
IPC分类号： G01N21/75
CPC分类号： G01N21/77 , C07D273/01 , C07D417/12 , G01N33/84
摘要： The invention relates to methods of determining sodium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the sodium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
摘要翻译： 本发明涉及测定样品中钠离子的方法，其中离子与具有发色部分和离子部分的化合物接触，其中离子部分与存在于样品中的钠离子相互作用，导致发色部分改变其 紫外线和可见光谱区的辐射吸收特性。 例如，测量吸收最大强度的变化，并且相应地确定离子浓度。
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公开(公告)号：US09360474B2
公开(公告)日：2016-06-07
申请号：US13689350
申请日：2012-11-29
发明人： Peter Chaoquan Zhu , Yingzi Wu
IPC分类号： G01N33/52 , C07D221/14 , G01N31/22 , G01N33/84
CPC分类号： G01N33/526 , C07D221/14 , G01N31/22 , G01N33/52 , G01N33/84
摘要： The invention relates to devices comprising a sensor layer capable of binding magnesium ions and a scavenging layer that preferentially binds to calcium ions in the presence of both magnesium ions and calcium ions. The sensor layers can comprise known or novel luminionophores. The invention further relates to methods of selectively detecting magnesium ion concentration in the presence of calcium ions.
摘要翻译： 本发明涉及包含能够结合镁离子的传感器层的装置和在镁离子和钙离子存在下优先结合钙离子的清除层。 传感器层可以包括已知或新颖的发光体。 本发明还涉及在钙离子存在下选择性地检测镁离子浓度的方法。
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4.发明申请公开(公告)号：US20080152864A1
公开(公告)日：2008-06-26
申请号：US11987984
申请日：2007-12-06
申请人： Narayanan Ramamurthy , Huarui He , Chao Lin
发明人： Narayanan Ramamurthy , Huarui He , Chao Lin
CPC分类号： G01N33/525 , B01D2253/202 , B01D2257/80 , B01J20/28033 , B01J20/28097 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N2021/7786 , Y10T428/24273 , Y10T428/265 , Y10T428/31504
摘要： The invention is directed to optical sensors for measuring clinically relevant analytes, their methods of manufacture, and their various uses. In an effort to develop a dry calibration method for the optical sensors of the invention it is discovered that water content inside or in the immediate vicinity of a such a sensor can have a major impact on fluorescence intensity (i.e., a sensor's response in the dry state). Thus, one of the objectives of the invention is the elimination of the bias of sensor responses measured at different humidity environments.
摘要翻译： 本发明涉及用于测量临床相关分析物，其制造方法及其各种用途的光学传感器。 为了开发用于本发明的光学传感器的干式校准方法，发现这种传感器内部或附近的含水量可能对荧光强度具有主要影响（即传感器在干燥时的响应） 州）。 因此，本发明的目标之一是消除在不同湿度环境下测量的传感器响应的偏差。
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公开(公告)号：US20070259443A1
公开(公告)日：2007-11-08
申请号：US11743569
申请日：2007-05-02
申请人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
发明人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
IPC分类号： G01N21/75
摘要： The invention relates to methods of determining potassium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the potassium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
摘要翻译： 本发明涉及测定样品中钾离子的方法，其中离子与具有发色部分和离子部分的化合物接触，其中离子部分与存在于样品中的钾离子相互作用，导致发色部分改变其 紫外线和可见光谱区的辐射吸收特性。 例如，测量吸收最大强度的变化，并且相应地确定离子浓度。
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公开(公告)号：US20120183984A1
公开(公告)日：2012-07-19
申请号：US13386021
申请日：2010-07-22
IPC分类号： G01N21/76 , C07D401/12 , C08B15/06 , C07D311/82 , C07C217/20 , C07C323/25 , C07F5/02 , C07D221/14 , C07C217/84
CPC分类号： C07D221/14 , C07D401/12 , Y10T436/206664
摘要： The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q+ is an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q+. The invention also provides methods of detecting and determining the presence of analytes and/or hydrogen peroxide in a sample, as well as a substrate that comprises the compound of formula I.
摘要翻译： 本发明提供式I F-L-Q（I）的化合物，其中F包含能够在激发波长处吸收能量的荧光团，并且在不存在猝灭剂的情况下发射不同于激发波长的发射波长的能量; Q包括猝灭剂; L包含具有两个末端的连接部分，一端与F共价结合，另一端与Q共价结合。化合物能够经历可逆反应（1），其如下：（1）其中Q +是氧化的 形式Q表示不存在猝灭剂，Ox包含氧化剂，其能够将Q氧化成其氧化形式Q，并且Red包含还原剂，其能够将Q转化为其还原形式Q.化合物 当能量照射时，当Q以其氧化态存在时，可以进行光诱导电子转移。 本发明还提供了检测和确定样品中分析物和/或过氧化氢的存在以及包含式I化合物的底物的方法。
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7.发明授权公开(公告)号：US08158259B2
公开(公告)日：2012-04-17
申请号：US11987984
申请日：2007-12-06
申请人： Narayanan Ramamurthy , Huarui He , Chao Lin
发明人： Narayanan Ramamurthy , Huarui He , Chao Lin
CPC分类号： G01N33/525 , B01D2253/202 , B01D2257/80 , B01J20/28033 , B01J20/28097 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N2021/7786 , Y10T428/24273 , Y10T428/265 , Y10T428/31504
摘要： The invention is directed to optical sensors for measuring clinically relevant analytes, their methods of manufacture, and their various uses. In an effort to develop a dry calibration method for the optical sensors of the invention it is discovered that water content inside or in the immediate vicinity of a such a sensor can have a major impact on fluorescence intensity (i.e., a sensor's response in the dry state). Thus, one of the objectives of the invention is the elimination of the bias of sensor responses measured at different humidity environments.
摘要翻译： 本发明涉及用于测量临床相关分析物，其制造方法及其各种用途的光学传感器。 为了开发用于本发明的光学传感器的干式校准方法，发现这种传感器内部或附近的含水量可能对荧光强度具有主要影响（即，传感器在干燥时的响应 州）。 因此，本发明的目标之一是消除在不同湿度环境下测量的传感器响应的偏差。
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公开(公告)号：US07858383B2
公开(公告)日：2010-12-28
申请号：US11743576
申请日：2007-05-02
申请人： Huarui He , Chao Lin , Neeta Raje , Chusheng Liu
发明人： Huarui He , Chao Lin , Neeta Raje , Chusheng Liu
IPC分类号： G01N21/75
CPC分类号： G01N21/77 , C07D273/01 , C07D417/12 , G01N33/84
摘要： The invention relates to methods of determining sodium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the sodium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
摘要翻译： 本发明涉及测定样品中钠离子的方法，其中离子与具有发色部分和离子部分的化合物接触，其中离子部分与存在于样品中的钠离子相互作用，导致发色部分改变其 紫外线和可见光谱区的辐射吸收特性。 例如，测量吸收最大强度的变化，并且相应地确定离子浓度。
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公开(公告)号：US20070259438A1
公开(公告)日：2007-11-08
申请号：US11743571
申请日：2007-05-02
IPC分类号： G01N33/20 , C07C245/08
CPC分类号： C07C245/08
摘要： The invention relates to methods of determining calcium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the calcium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
摘要翻译： 本发明涉及测定样品中钙离子的方法，其中离子与具有发色部分和离子部分的化合物接触，其中离子部分与样品中存在的钙离子相互作用，导致发色部分改变其 紫外线和可见光谱区的辐射吸收特性。 例如，测量吸收最大强度的变化，并且相应地确定离子浓度。
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公开(公告)号：US07960181B2
公开(公告)日：2011-06-14
申请号：US11743569
申请日：2007-05-02
申请人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
发明人： Huarui He , Chao Lin , Neeta Raje , Chuseng Liu
IPC分类号： C07D245/00 , C07D245/04 , C07D245/06 , C07D487/00
摘要： The invention relates to methods of determining potassium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the potassium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
摘要翻译： 本发明涉及测定样品中钾离子的方法，其中离子与具有发色部分和离子部分的化合物接触，其中离子部分与存在于样品中的钾离子相互作用，导致发色部分改变其 紫外线和可见光谱区的辐射吸收特性。 例如，测量吸收最大强度的变化，并且相应地确定离子浓度。
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