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公开(公告)号：US10888625B2
公开(公告)日：2021-01-12
申请号：US14438655
申请日：2013-10-29
发明人： Mark Mitchnick , Garry Gwozdz , Andrew Loxley
摘要： A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.
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2.发明申请公开(公告)号：US20190254974A1
公开(公告)日：2019-08-22
申请号：US16291720
申请日：2019-03-04
摘要： Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.
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3.发明授权Methods and devices for detecting binding events via zeta-potential and pharmacologically active compounds and delivery systems identified thereby 有权用于通过ζ-电位和药理活性化合物检测结合事件的方法和装置以及由此鉴定的递送系统公开(公告)号：US09274106B2
公开(公告)日：2016-03-01
申请号：US12593616
申请日：2008-04-04
申请人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
发明人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
IPC分类号： G01N33/542 , G01N33/543
CPC分类号： G01N33/54373 , G01N33/542 , G01N33/54313
摘要： Methods, devices and arrays for measuring a change in zeta-potential of a surface indicative of a binding event are provided. Pharmacologically active compounds and delivery systems for active pharmaceutical ingredients determined to be pharmacologically active or optimized for pharmacological activity or determined to be useful for delivery of the active pharmaceutical ingredient to a target via measurement of a change in zeta-potential of the compound, ingredient or delivery system are also provided.
摘要翻译： 提供了用于测量指示结合事件的表面的ζ电位变化的方法，装置和阵列。 活性药物成分的药理学活性化合物和递送系统被确定为药理学活性或针对药理学活性而优化，或被确定为可用于通过测量化合物，成分或成分的ζ-电位变化将活性药物成分递送至靶标 还提供送货系统。
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公开(公告)号：US07419527B2
公开(公告)日：2008-09-02
申请号：US10434397
申请日：2003-05-08
申请人： Garry Gwozdz , Mark Mitchnick , David Fairhurst
发明人： Garry Gwozdz , Mark Mitchnick , David Fairhurst
CPC分类号： B22F1/007 , B22F1/0059 , B22F2998/00 , C04B35/62821 , C04B35/62823 , C04B35/62834
摘要： Novel powders or particles are formed by associating them with relatively small proportions of hydrolysable liquid material. The resulting particle/liquid mass is placed in a mold and sintered under conditions of heat and pressure that enables at least some of the hydrolysable liquid to react within the sintered mass. The sintered mass displays a controllable range of properties such as increased density, increased tensile strength, and improved natural polish finish. The hydrolysable liquid may partially hydrolyze and/or react with the powders and particles, but the liquid is not completely (not 100%) reduced to an inorganic oxide prior to introduction to the mold and performance of the sintering process.
摘要翻译： 通过将它们与相对小比例的可水解液体材料缔合而形成新的粉末或颗粒。 将所得的颗粒/液体物质置于模具中并在热和压力条件下烧结，使至少一些可水解液体在烧结体内发生反应。 烧结体显示出可控范围的特性，例如增加的密度，增加的拉伸强度和改进的天然抛光光洁度。 可水解液体可能部分水解和/或与粉末和颗粒反应，但是在引入模具和执行烧结过程之前，液体不会完全（不是100％）还原成无机氧化物。
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公开(公告)号：US20040221682A1
公开(公告)日：2004-11-11
申请号：US10434397
申请日：2003-05-08
发明人： Garry Gwozdz , Mark Mitchnick , David Fairhurst
IPC分类号： B22F003/10
CPC分类号： B22F1/007 , B22F1/0059 , B22F2998/00 , C04B35/62821 , C04B35/62823 , C04B35/62834
摘要： Novel powders or particles are formed by associating them with relatively small proportions of hydrolysable liquid material. The resulting particle/liquid mass is placed in a mold and sintered under conditions of heat and pressure that enables at least some of the hydrolysable liquid to react within the sintered mass. The sintered mass displays a controllable range of properties such as increased density, increased tensile strength, and improved natural polish finish. The hydrolysable liquid may partially hydrolyze and/or react with the powders and particles, but the liquid is not completely (not 100%) reduced to an inorganic oxide prior to introduction to the mold and performance of the sintering process.
摘要翻译： 通过将它们与相对小比例的可水解液体材料缔合而形成新的粉末或颗粒。 将所得的颗粒/液体物质置于模具中并在热和压力条件下烧结，使至少一些可水解液体在烧结体内发生反应。 烧结体显示出可控范围的特性，例如增加的密度，增加的拉伸强度和改进的天然抛光光洁度。 可水解液体可能部分水解和/或与粉末和颗粒反应，但是在引入模具和执行烧结过程之前，液体不会完全（不是100％）还原成无机氧化物。
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公开(公告)号：US20220125715A1
公开(公告)日：2022-04-28
申请号：US17430521
申请日：2020-02-14
摘要： A delivery device for active pharmaceutical agents and made up of a hollow polymeric outer shape forming at least one closed internal cavity or compartment and containing a solid core of one or more active pharmaceutical agents and one or more excipients substantially unattached to the hollow polymeric outer shape is provided. Also provided are methods for production and use of this device.
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7.发明授权公开(公告)号：US10258571B2
公开(公告)日：2019-04-16
申请号：US12525568
申请日：2008-02-12
摘要： Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.
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8.发明授权公开(公告)号：US08540969B2
公开(公告)日：2013-09-24
申请号：US12596508
申请日：2008-04-18
申请人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
发明人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
CPC分类号： A61K9/5123 , A61K9/0078 , A61K9/008
摘要： Aerosols containing a plurality of aqueous droplets, each droplet containing on average at least one essentially-neutral particle sized to fit within the droplet are provided. Aerosols wherein an active pharmaceutical ingredient is attached to, or otherwise incorporated in the essentially neutral particles are also provided. Methods for administering an active pharmaceutical ingredient to a subject in need thereof via inhalation of these aerosols, preferably via nebulizer, are also provided.
摘要翻译： 提供了含有多个水滴的气溶胶，每个液滴平均包含至少一个基本上为中性的粒子，其尺寸适于装配在液滴内。 还提供其中活性药物成分连接至或以其他方式并入基本上中性的颗粒的气溶胶。 还提供了通过吸入这些气溶胶，优选通过喷雾器向有需要的受试者施用活性药物成分的方法。
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