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    DRUG DELIVERY PARTICLE FORMULATIONS WITH TARGETING MOIETIES
    4.
    发明申请
    DRUG DELIVERY PARTICLE FORMULATIONS WITH TARGETING MOIETIES 审中-公开
    药物递送颗粒配方与目标动物

    公开(公告)号：US20150297751A1

    公开(公告)日：2015-10-22

    申请号：US14438655

    申请日：2013-10-29

    申请人： Particle Sciences, Inc.

    发明人： Mark Mitchnick ,  Garry Gwozdz ,  Andrew Loxley

    IPC分类号： A61K47/48 ,  A61K9/16

    CPC分类号： A61K47/6835 ,  A61K9/1617 ,  A61K47/6937

    摘要： A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.

    摘要翻译： 提供了含有颗粒，静电连接到颗粒上的靶向部分和附着于或分散或溶解在颗粒内的活性药物成分的靶向药物递送复合物。 还提供了含有多种复合物的药物制剂以及用于将活性药物成分靶向所选择的细胞或组织以及制备这些制剂的方法。

    Increased density particle molding
    5.
    发明申请
    Increased density particle molding 有权
    增加密度颗粒成型

    公开(公告)号：US20040221682A1

    公开(公告)日：2004-11-11

    申请号：US10434397

    申请日：2003-05-08

    申请人： Particle Sciences, Inc.

    发明人： Garry Gwozdz ,  Mark Mitchnick ,  David Fairhurst

    IPC分类号： B22F003/10

    CPC分类号： B22F1/007 ,  B22F1/0059 ,  B22F2998/00 ,  C04B35/62821 ,  C04B35/62823 ,  C04B35/62834

    摘要： Novel powders or particles are formed by associating them with relatively small proportions of hydrolysable liquid material. The resulting particle/liquid mass is placed in a mold and sintered under conditions of heat and pressure that enables at least some of the hydrolysable liquid to react within the sintered mass. The sintered mass displays a controllable range of properties such as increased density, increased tensile strength, and improved natural polish finish. The hydrolysable liquid may partially hydrolyze and/or react with the powders and particles, but the liquid is not completely (not 100%) reduced to an inorganic oxide prior to introduction to the mold and performance of the sintering process.

    摘要翻译： 通过将它们与相对小比例的可水解液体材料缔合而形成新的粉末或颗粒。 将所得的颗粒/液体物质置于模具中并在热和压力条件下烧结，使至少一些可水解液体在烧结体内发生反应。 烧结体显示出可控范围的特性，例如增加的密度，增加的拉伸强度和改进的天然抛光光洁度。 可水解液体可能部分水解和/或与粉末和颗粒反应，但是在引入模具和执行烧结过程之前，液体不会完全（不是100％）还原成无机氧化物。

    IMPLANTABLE AND REMOVABLE DRUG DELIVERY DEVICE
    7.
    发明申请
    IMPLANTABLE AND REMOVABLE DRUG DELIVERY DEVICE 审中-公开

    公开(公告)号：US20200375890A1

    公开(公告)日：2020-12-03

    申请号：US16496522

    申请日：2018-03-16

    申请人： Particle Sciences, Inc.

    发明人： Mark A. Mitchnick ,  Kimberly A. Zubris ,  Brett Braker

    IPC分类号： A61K9/00 ,  A61K45/06

    摘要： The disclosed technology provides an improved drug delivery device which is easily implantable and removable, as well as method of using and making the same. The described drug delivery device includes: (a) a wall comprising at least in part a polymeric composition, which surrounds and forms; (b) a compartment; (c) a drug composition in the compartment which includes an active agent; (d) at least one passageway in the wall for releasing the active agent from said drug composition to said environment of use. The device (i) can be implanted in an environment of use, (ii) is able to maintain its structural integrity for a period of use to allow for the release of the active agent, and (iii) can then be removed from the environment of use.