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1.发明授权Methods and devices for detecting binding events via zeta-potential and pharmacologically active compounds and delivery systems identified thereby 有权用于通过ζ-电位和药理活性化合物检测结合事件的方法和装置以及由此鉴定的递送系统公开(公告)号：US09274106B2
公开(公告)日：2016-03-01
申请号：US12593616
申请日：2008-04-04
申请人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
发明人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
IPC分类号： G01N33/542 , G01N33/543
CPC分类号： G01N33/54373 , G01N33/542 , G01N33/54313
摘要： Methods, devices and arrays for measuring a change in zeta-potential of a surface indicative of a binding event are provided. Pharmacologically active compounds and delivery systems for active pharmaceutical ingredients determined to be pharmacologically active or optimized for pharmacological activity or determined to be useful for delivery of the active pharmaceutical ingredient to a target via measurement of a change in zeta-potential of the compound, ingredient or delivery system are also provided.
摘要翻译： 提供了用于测量指示结合事件的表面的ζ电位变化的方法，装置和阵列。 活性药物成分的药理学活性化合物和递送系统被确定为药理学活性或针对药理学活性而优化，或被确定为可用于通过测量化合物，成分或成分的ζ-电位变化将活性药物成分递送至靶标 还提供送货系统。
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2.发明申请Methods and Devices for Detecting Binding Events via Zeta-Potential and Pharmacologically Active Compounds and Delivery Systems Identified Thereby 有权通过Zeta电位和药理活性化合物和递送系统检测结合事件的方法和装置由此识别公开(公告)号：US20100086608A1
公开(公告)日：2010-04-08
申请号：US12593616
申请日：2008-04-04
申请人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
发明人： Mark Mitchnick , Andrew Loxley , David Fairhurst , Peter Wagner
IPC分类号： A61K9/14 , G01N33/566 , G01N30/96 , A61K38/00 , A61K31/7088 , A61K31/70 , A61K38/16
CPC分类号： G01N33/54373 , G01N33/542 , G01N33/54313
摘要： Methods, devices and arrays for measuring a change in zeta-potential of a surface indicative of a binding event are provided. Pharmacologically active compounds and delivery systems for active pharmaceutical ingredients determined to be pharmacologically active or optimized for pharmacological activity or determined to be useful for delivery of the active pharmaceutical ingredient to a target via measurement of a change in zeta-potential of the compound, ingredient or delivery system are also provided.
摘要翻译： 提供了用于测量指示结合事件的表面的ζ电位变化的方法，装置和阵列。 活性药物成分的药理学活性化合物和递送系统被确定为药理学活性或针对药理学活性而优化，或被确定为可用于通过测量化合物，成分或成分的ζ-电位变化将活性药物成分递送至靶标 还提供送货系统。
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3.发明授权公开(公告)号：US10258571B2
公开(公告)日：2019-04-16
申请号：US12525568
申请日：2008-02-12
摘要： Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.
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公开(公告)号：US20100062071A1
公开(公告)日：2010-03-11
申请号：US12593029
申请日：2008-03-31
CPC分类号： A61K9/10 , A61K9/5123 , A61K39/39 , A61K2039/55555
摘要： Aqueous dispersions of chemically and physically stable particles for use in delivery of active pharmaceutical ingredients and processes for their production and use to enhance a biological response to an active pharmaceutical ingredient and prophylactically or therapeutically treat a subject are provided. Vaccines, wherein the active pharmaceutical ingredient is a solution of subunit vaccine antigen mixed with a colloidal dispersion of electrically charged particles and use of such vaccines in immunization are also provided.
摘要翻译： 提供用于递送活性药物成分的化学和物理稳定的颗粒的水性分散体及其生产和用途的方法，以增强对活性药物成分的生物反应和预防或治疗性治疗受试者。 疫苗，其中活性药物成分是与带电粒子的胶体分散体混合的亚单位疫苗抗原的溶液，并且在免疫中使用这种疫苗。
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公开(公告)号：US11246831B2
公开(公告)日：2022-02-15
申请号：US12593029
申请日：2008-03-31
摘要： Aqueous dispersions of chemically and physically stable particles for use in delivery of active pharmaceutical ingredients and processes for their production and use to enhance a biological response to an active pharmaceutical ingredient and prophylactically or therapeutically treat a subject are provided. Vaccines, wherein the active pharmaceutical ingredient is a solution of subunit vaccine antigen mixed with a colloidal dispersion of electrically charged particles and use of such vaccines in immunization are also provided.
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6.发明申请Delivery Devices Containing Encapsulated and/or Particle-Bound Active Pharmaceutical Ingredients 审中-公开包含封装和/或颗粒结合的活性药物成分的输送装置公开(公告)号：US20100034863A1
公开(公告)日：2010-02-11
申请号：US12525568
申请日：2008-02-12
CPC分类号： A61K9/1617 , A61K9/0031 , A61K9/0036 , A61K9/0043 , A61K9/0056 , A61L31/16
摘要： Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.
摘要翻译： 提供了具有一种或多种包封的活性药物成分或一种或多种分散在基质中的颗粒结合的活性药物成分的可降解或不可降解的生物相容性基质的递送装置。 还提供了用这些递送装置将活性药物成分递送到受试者的方法。 还提供了修改的阴道环以及用于递送装置的表面涂层，其使涂覆的递送装置的生物相互作用最小化。
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公开(公告)号：US08895546B2
公开(公告)日：2014-11-25
申请号：US13495942
申请日：2012-06-13
申请人： Steve Cartt , David Medeiros , Garry Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David Hale , Edward T. Maggio
发明人： Steve Cartt , David Medeiros , Garry Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David Hale , Edward T. Maggio
IPC分类号： A61K31/55 , A61K9/00 , A61K31/355 , A61K31/5513 , A61K45/06
CPC分类号： A61K9/0043 , A61K9/008 , A61K9/08 , A61K31/355 , A61K31/5513 , A61K45/06 , A61K47/10 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.
摘要翻译： 本发明涉及包含一种或多种用于鼻内给药的苯并二氮类药物的药物组合物，用于制备和使用这些组合物的方法。
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8.发明授权Bi-functional co-polymer use for opthalmic and other topical and local applications 有权双功能共聚物用于眼科和其他局部和局部应用公开(公告)号：US08802075B2
公开(公告)日：2014-08-12
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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9.发明授权公开(公告)号：US08540969B2
公开(公告)日：2013-09-24
申请号：US12596508
申请日：2008-04-18
申请人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
发明人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
CPC分类号： A61K9/5123 , A61K9/0078 , A61K9/008
摘要： Aerosols containing a plurality of aqueous droplets, each droplet containing on average at least one essentially-neutral particle sized to fit within the droplet are provided. Aerosols wherein an active pharmaceutical ingredient is attached to, or otherwise incorporated in the essentially neutral particles are also provided. Methods for administering an active pharmaceutical ingredient to a subject in need thereof via inhalation of these aerosols, preferably via nebulizer, are also provided.
摘要翻译： 提供了含有多个水滴的气溶胶，每个液滴平均包含至少一个基本上为中性的粒子，其尺寸适于装配在液滴内。 还提供其中活性药物成分连接至或以其他方式并入基本上中性的颗粒的气溶胶。 还提供了通过吸入这些气溶胶，优选通过喷雾器向有需要的受试者施用活性药物成分的方法。
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10.发明申请公开(公告)号：US20100124535A1
公开(公告)日：2010-05-20
申请号：US12596508
申请日：2008-04-18
申请人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
发明人： Andrew Loxley , Ismar Dizdarevic , Mark Mitchnick
IPC分类号： A61K9/72 , A61P11/00 , A61P11/06 , A61P11/16 , A61P19/00 , A61P5/14 , A61P25/24 , A61P33/06 , A61P13/00
CPC分类号： A61K9/5123 , A61K9/0078 , A61K9/008
摘要： Aerosols containing a plurality of aqueous droplets, each droplet containing on average at least one essentially-neutral particle sized to fit within the droplet are provided. Aerosols wherein an active pharmaceutical ingredient is attached to, or otherwise incorporated in the essentially neutral particles are also provided. Methods for administering an active pharmaceutical ingredient to a subject in need thereof via inhalation of these aerosols, preferably via nebulizer, are also provided.
摘要翻译： 提供了含有多个水滴的气溶胶，每个液滴平均包含至少一个基本上为中性的粒子，其尺寸适于装配在液滴内。 还提供其中活性药物成分连接至或以其他方式并入基本上中性的颗粒的气溶胶。 还提供了通过吸入这些气溶胶，优选通过喷雾器向有需要的受试者施用活性药物成分的方法。
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