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1.发明公开公开(公告)号：US20240132477A1
公开(公告)日：2024-04-25
申请号：US18257136
申请日：2021-12-13
Applicant: PFIZER INC.
Inventor： Scott William Bagley , Agustin Casimiro Garcia , Jennifer Elizabeth Davoren , Rajiah Aldrin Denny , Brian Stephen Gerstenberger , Frank Eldridge Lovering , Mihir Dineshkumar Parikh , Joseph Walter Strohbach , John Isidro Trujillo
IPC: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
CPC classification number: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
Abstract: The invention relates to benzimidazoles of Formula (I)
and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.
The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.-
公开(公告)号：US11661419B2
公开(公告)日：2023-05-30
申请号：US17126358
申请日：2020-12-18
Applicant: Pfizer Inc.
Inventor： Scott William Bagley , Agustin Casimiro-Garcia , Xiayun Cheng , Jennifer Elizabeth Davoren , Rajiah Aldrin Denny , Brian Stephen Gerstenberger , Frank Eldridge Lovering , Mihir Dineshkumar Parikh , Joseph Walter Strohbach , John Isidro Trujillo
IPC: C07D413/14 , A61P17/00 , A61K45/06
CPC classification number: C07D413/14 , A61K45/06 , A61P17/00
Abstract: The invention relates to benzimidazoles of Formula (I)
and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.
The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.-
公开(公告)号：US20230280220A1
公开(公告)日：2023-09-07
申请号：US18301475
申请日：2023-04-17
Applicant: Pfizer Inc.
Inventor： Scott William Bagley , Agustin Casimiro Garcia , Xiayun Cheng , Jennifer Elizabeth Davoren , Rajiah Aldrin Denny , Brian Stephen Gerstenberger , Frank Eldridge Lovering , Mihir Dineshkumar Parikh , Joseph Walter Strohbach , John Isidro Trujillo
IPC: G01L1/25 , G01N23/207
CPC classification number: G01L1/25 , G01N23/207
Abstract: The invention relates to benzimidazoles of Formula (1)
and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.
The benzimidazoles of Formula (1) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.-
公开(公告)号：US10793579B2
公开(公告)日：2020-10-06
申请号：US16411679
申请日：2019-05-14
Applicant: Pfizer Inc.
Inventor： John David Trzupek , Katherine Lin Lee , Mark Edward Bunnage , Seungil Han , David Hepworth , Frank Eldridge Lovering , John Paul Mathias , Nikolaos Papaioannou , Betsy Susan Pierce , Joseph Walter Strohbach , Stephen Wayne Wright , Christoph Wolfgang Zapf , Lori Krim Gavrin , Arthur Lee , David Randolph Anderson , Kevin Joseph Curran , Christoph Martin Dehnhardt , Eddine Saiah , Joel Adam Goldberg , Xiaolun Wang , Horng-Chih Huang , Richard Vargas , Michael Dennis Lowe , Akshay Patny
IPC: C07D401/14 , A61K31/47 , A61K31/4709 , A61K31/4725 , C07D491/056 , C07F7/18 , C07D405/14 , C07D217/02 , C07D217/22 , C07D217/24 , C07C69/94 , C07D239/86 , C07D239/88 , C07D263/24 , C07D207/273 , C07D498/04 , C07D209/52 , A61K31/4015 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D207/26 , C07D215/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , A61K31/40 , C07D207/08 , C07D207/267
Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：US20180127432A1
公开(公告)日：2018-05-10
申请号：US15862691
申请日：2018-01-05
Applicant: Pfizer Inc.
Inventor： John David Trzupek , Katherine Lin Lee , Mark Edward Bunnage , Seungil Han , David Hepworth , Frank Eldridge Lovering , John Paul Mathias , Nikolaos Papaioannou , Betsy Susan Pierce , Joseph Walter Strohbach , Stephen Wayne Wright , Christoph Wolfgang Zapf , Lori Krim Gavrin , Arthur Lee , David Randolph Anderson , Kevin Joseph Curran , Christoph Martin Dehnhardt , Eddine Saiah , Joel Adam Goldberg , Xiaolun Wang , Horng-Chih Huang , Richard Vargas , Michael Dennis Lowe , Akshay Patny
IPC: C07D491/056 , C07D239/88 , C07D239/86 , C07D263/24 , C07D207/267 , A61K31/40 , C07D207/08 , C07F7/18 , C07D209/52 , C07D498/04 , C07D207/273 , C07C69/94 , C07D217/24 , C07D217/22 , C07D217/02 , C07D405/14 , C07D401/14 , C07D487/04 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D407/14 , C07D215/48 , C07D207/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/4015
CPC classification number: C07D491/056 , A61K31/40 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C69/94 , C07D207/08 , C07D207/26 , C07D207/267 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07F7/1804
Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20160347760A1
公开(公告)日：2016-12-01
申请号：US15232892
申请日：2016-08-10
Applicant: Pfizer Inc.
Inventor： John David Trzupek , Katherine Lin Lee , Mark Edward Bunnage , Seungil Han , David Hepworth , Frank Eldridge Lovering , John Paul Mathias , Nikolaos Papaioannou , Betsy Susan Pierce , Joseph Walter Strohbach , Stephen Wayne Wright , Christoph Wolfgang Zapf , Lori Krim Gavrin , Arthur Lee , David Randolph Anderson , Kevin Joseph Curran , Christoph Martin Dehnhardt , Eddine Saiah , Joel Adam Goldberg , Xiaolun Wang , Horng-Chih Huang , Richard Vargas , Michael Dennis Lowe , Akshay Patny
IPC: C07D491/056 , A61K31/4709 , C07D405/12 , C07D215/48 , A61K31/47 , A61K31/4725 , C07D417/12 , A61K31/541 , C07D413/12 , A61K31/5377 , C07D207/267 , A61K31/4015 , C07D207/08 , A61K31/40 , C07D407/14 , C07D487/04 , C07D403/12 , A61K31/517 , A61K45/06 , C07D401/12
CPC classification number: C07D491/056 , A61K31/40 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C69/94 , C07D207/08 , C07D207/26 , C07D207/267 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07F7/1804
Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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![Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease](/abs-image/US/2024/04/18/US20240124439A1/abs.jpg.150x150.jpg)
7.发明公开公开(公告)号：US20240124439A1
公开(公告)日：2024-04-18
申请号：US18257195
申请日：2021-12-13
Applicant: Pfizer Inc.
Inventor： Scott William Bagley , Agustin Casimiro-Garcia , Jennifer Elizabeth Davoren , Rajiah Aldrin Denny , Brian Stephen Gerstenberger , Katherine Lin Lee , Frank Eldridge Lovering , Mihir Dineshkumar Parikh , Joseph Walter Strohbach , John Isidro Trujillo
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The invention relates to imidazopyridines of Formula (I)
and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.
The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.-
公开(公告)号：US10906888B2
公开(公告)日：2021-02-02
申请号：US16316688
申请日：2017-07-07
Applicant: Pfizer Inc.
Inventor： Agustin Casimiro-Garcia , Joseph Walter Strohbach , David Hepworth , Frank Eldridge Lovering , Chulho Choi , Christophe Philippe Allais , Stephen Wayne Wright
IPC: C07D401/14 , C07D403/14 , C07D413/14 , C07D471/08 , C07D487/04 , C07D487/10 , C07D491/107 , C07D498/10 , C07D498/18
Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：US09458168B2
公开(公告)日：2016-10-04
申请号：US14678114
申请日：2015-04-03
Applicant: Pfizer Inc.
Inventor： John David Trzupek , Katherine Lin Lee , Mark Edward Bunnage , Seungil Han , David Hepworth , Frank Eldridge Lovering , John Paul Mathias , Nikolaos Papaioannou , Joseph Walter Strohbach , Stephen Wayne Wright , Christoph Wolfgang Zapf , Lori Krim Gavrin , Arthur Lee , Kevin Joseph Curran , Christoph Martin Dehnhardt , Eddine Saiah , Joel Adam Goldberg , Xiaolun Wang , Richard Vargas , Michael Dennis Lowe , Akshay Patny
IPC: C07D207/26 , C07D401/12 , A61K31/44 , C07D491/056 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D215/48 , C07D403/12 , C07D405/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D401/14 , C07D405/14 , C07D217/02 , C07D217/22 , C07D217/24 , C07C69/94 , C07D239/86 , C07D239/88 , C07D263/24 , C07D207/273 , C07D498/04 , C07D209/52 , C07F7/18
CPC classification number: C07D491/056 , A61K31/40 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C69/94 , C07D207/08 , C07D207/26 , C07D207/267 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07F7/1804
Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：US20210188829A1
公开(公告)日：2021-06-24
申请号：US17126358
申请日：2020-12-18
Applicant: Pfizer Inc.
Inventor： Scott William Bagley , Agustin Casimiro-Garcia , Xiayun Cheng , Jennifer Elizabeth Davoren , Rajiah Aldrin Denny , Brian Stephen Gerstenberger , Frank Eldridge Lovering , Mihir Dineshkumar Parikh , Joseph Walter Strohbach , John Isidro Trujillo
IPC: C07D413/14 , A61K45/06 , A61P17/00
Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.
The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.
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