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公开(公告)号：US20250120805A1
公开(公告)日：2025-04-17
申请号：US18999207
申请日：2024-12-23
Applicant: SHEBA IMPACT LTD.
Inventor： Boris Orlov , Ehud Raanani
Abstract: Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in the left atrium of a subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.
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公开(公告)号：US20240271135A1
公开(公告)日：2024-08-15
申请号：US18442518
申请日：2024-02-15
Applicant: SHEBA IMPACT LTD.
Inventor： Yehuda KAMARI , Michal KANDEL-KFIR , Dror HARATS , Dan DOMINISSINI , Gideon RECHAVI , Aviv SHAISH
IPC: C12N15/113 , A61K45/06 , A61P3/06
CPC classification number: C12N15/113 , A61K45/06 , A61P3/06 , C12N2310/11 , C12N2310/351
Abstract: This disclosure is directed to compositions comprising an RNA therapeutic targeting FAT10 and uses of same.
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公开(公告)号：US20240319194A1
公开(公告)日：2024-09-26
申请号：US18574790
申请日：2022-06-29
Applicant: Sheba Impact Ltd.
Inventor： Doron YABLECOVITCH , Ido LAISH
IPC: G01N33/574 , A61K45/06
CPC classification number: G01N33/57438 , A61K45/06
Abstract: A method of diagnosing pancreatic cancer in a subject in need thereof is provided. The method comprising determining a level of at least syndecan 1 (SDC1) in a blood sample or a fraction thereof of the subject, wherein when the level of SDC1 is above a predetermined threshold, the subject is diagnosed with pancreatic cancer.
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公开(公告)号：US20240193764A1
公开(公告)日：2024-06-13
申请号：US18286567
申请日：2022-04-13
Inventor： Chen SPETER , Doron MANZUR , Chen GILADI
CPC classification number: G06T7/0012 , A61B8/488 , G06T7/11 , G06T7/70 , G06T15/00 , G06T2207/10132 , G06T2207/30104
Abstract: There is provided a method for reconstructing a 3D image, comprising: obtaining Doppler ultrasound images depicting a blood vessel and measurement of blood flow in the blood vessel, and 2D camera images captured by a camera depicting fiducial objects randomly distributed within a viscous material and spaced apart by random distances on a surface of the individual, computing 3D coordinates within a world coordinate system for pixels of the Doppler images using an external reference of an ultrasound transducer pose computed by analysis of relative changes in locations of the fiducial objects within sequential camera images, and computing a respective estimated blood flow for pixels of the Doppler images at locations within the blood vessel, reconstructing a 3D image from 3D voxels computed from the 3D coordinates of pixels of the Doppler images, including respective estimated blood flow, wherein the 3D image depicts the blood vessel and blood flow.
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公开(公告)号：US20240067742A1
公开(公告)日：2024-02-29
申请号：US18375657
申请日：2023-10-02
Applicant: 4C BIOMED LIMITED , SHEBA IMPACT LTD.
Inventor： Eyal GREENBERG , Gilli GALORE-HASKEL , Efrat MERHAVI-SHOHAM , Gal MARKEL
CPC classification number: C07K16/2878 , A61P35/00 , G01N33/6863 , C07K2317/565 , G01N2800/52
Abstract: Antibodies or antigen binding fragments thereof that bind HVEM, inhibit HVEM-BTLA interaction and allow binding to LIGHT are provided. Methods of treating disease with these antibodies or antigen binding fragments thereof, nucleic acid molecules encoding these antibodies or antigen binding fragments thereof and kits comprising these antibodies or antigen binding fragments thereof are also provided.
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Patent Agency Ranking
公开(公告)号：US20240029249A1
公开(公告)日：2024-01-25
申请号：US18376460
申请日：2023-10-04
Applicant: Sheba Impact Ltd.
Inventor： Yael MARDOR , David LAST , Dianne DANIELS ELMAKIAS , Shirley SHARABI , Jair BAR , Nadav FORIE , Liran LEVY , Edith Michelle MAROM
CPC classification number: G06T7/0012 , G06T7/254 , A61B6/032 , A61B6/481 , G06T2207/10081 , G06T2207/30061
Abstract: A method of analyzing CT data comprises receiving data describing a pre-contrast administration CT scan from a body region of the subject, and a post-contrast administration CT scan acquired from the body region at least 1 minute after initiation of administration of a contrast agent to the subject. A subtraction map is formed by subtracting one of the scans from another. The subtraction map is displayed in a manner that identifies leaking of contrast agent out of blood vessels in the region.
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公开(公告)号：US20250073292A1
公开(公告)日：2025-03-06
申请号：US18293996
申请日：2022-08-02
Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL R , SHEBA IMPACT LTD.
Inventor： Sigal LIRAZ ZALTSMAN , Anat ELMANN , Nativ DUDAI
IPC: A61K36/185 , A61K31/045 , A61P25/00 , A61P25/28
Abstract: The present invention provides methods and compositions comprising essential oil extracted from Pelargonium graveolens for treating, preventing, or ameliorating traumatic brain injury (TBI) in a subject, or for improving cognitive functions in a subject suffering from TBI.
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公开(公告)号：US20240261257A1
公开(公告)日：2024-08-08
申请号：US18408663
申请日：2024-01-10
Applicant: Sheba Impact Ltd. , Ministry of Health, State of Israel
Inventor： Yaacov DAVIDOV , Galia RAHAV , Alla USYSKIN-TONNE , Alex SHULMAN , Ari ROBINSON , Israel Ronen NISSAN , Noa Lea TEJMAN-YARDEN
IPC: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
CPC classification number: A61K31/357 , A61K31/4025 , A61K31/4433 , A61K33/24 , A61P31/04
Abstract: A method of treating an infection of a gram positive bacteria in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of enterobactin and/or an active derivative thereof. Compositions comprising enterobactin are also disclosed or active derivatives are also disclosed.
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公开(公告)号：US20240249409A1
公开(公告)日：2024-07-25
申请号：US18561749
申请日：2022-05-18
Applicant: Ramot at Tel-Aviv University Ltd. , Sheba Impact Ltd.
Inventor： Arnaldo MAYER , Tamir MANOR , Asaf HALLE , Nahum KIRYATI , Eliahu KONEN , Jana PICKOVSKY
CPC classification number: G06T7/0012 , G06T7/11 , G06T2207/10081 , G06T2207/20081 , G06T2207/20084 , G06T2207/30028
Abstract: A method of analyzing an abdominal computed tomography (CT) scan comprises applying a colon segmentation machine learning procedure to the CT scan, and receiving from the colon segmentation machine learning procedure an output indicative of a plurality of colon segments. The method also comprises feeding the output into a colon lesion detection machine learning procedure, and receiving from the colon lesion detection machine learning procedure an output indicative of presence of at least one pathology in the colon.
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公开(公告)号：US20240207045A1
公开(公告)日：2024-06-27
申请号：US17906332
申请日：2022-06-16
Applicant: SHEBA IMPACT LTD.
Inventor： Boris Orlov , Ehud Raanani
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2230/005 , A61F2250/001
Abstract: Apparatus and methods are described for use with a native tricuspid valve of a heart of a mammalian subject. A valve frame (22) includes a valve-frame body (32) that is configured to support prosthetic valve leaflets (20) within the native tricuspid valve. Chord-recruiting arms (30) are configured to extend from the valve-frame body at circumferential regions corresponding to the anterior leaflet and the posterior leaflet of the native tricuspid valve. An anchoring arm (28) is configured to extend from the valve-frame body at a circumferential region corresponding to the septal leaflet of the native tricuspid valve, the anchoring arm (28) being longer than each of the chord-recruiting arms (30). Other applications are also described.
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