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公开(公告)号：US20230233468A1
公开(公告)日：2023-07-27
申请号：US18163117
申请日：2023-02-01
发明人： Bo YING , Xiulian WANG
IPC分类号： A61K9/16 , C07C217/28 , C07C219/06 , C07D295/13 , C07C229/22 , C07C229/16 , C07C235/06 , C07D207/24
CPC分类号： A61K9/1617 , C07C217/28 , C07C219/06 , C07D295/13 , C07C229/22 , C07C229/16 , C07C235/06 , C07D207/24 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
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公开(公告)号：US11510977B2
公开(公告)日：2022-11-29
申请号：US17589703
申请日：2022-01-31
发明人： Bo Ying
IPC分类号： A61K39/215 , A61P31/14 , A61K39/00
摘要： Provided herein are therapeutic nucleic acid molecules for managing, preventing and/or treating infectious diseases caused by coronavirus. Also provided herein are therapeutic compositions, including vaccines and lipid nanoparticles, comprising the therapeutic nucleic acids and related therapeutic methods and uses.
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公开(公告)号：US20240218399A1
公开(公告)日：2024-07-04
申请号：US18556299
申请日：2022-10-07
发明人： Dandan LING , Xiaobin PAN , Jerry ZHANG , Bo YING
IPC分类号： C12N15/88
CPC分类号： C12N15/88
摘要： Provided herein are sphingomyelin-containing compositions, and related nanoparticle compositions, lipid nanoparticles, including lipid raft nanoparticles. Also provided herein are related methods and uses of the nanoparticle compositions for delivering nucleic acid molecules to achieve enhanced nucleic acid expression.
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公开(公告)号：US20240042010A1
公开(公告)日：2024-02-08
申请号：US18052178
申请日：2022-11-02
发明人： Bo Ying
IPC分类号： A61K39/215 , A61P31/14
CPC分类号： A61K39/215 , A61P31/14 , A61K2039/53
摘要： Provided herein are therapeutic nucleic acid molecules for managing, preventing and/or treating infectious diseases caused by coronavirus. Also provided herein are therapeutic compositions, including vaccines and lipid nanoparticles, comprising the therapeutic nucleic acids and related therapeutic methods and uses.
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公开(公告)号：US20230348362A1
公开(公告)日：2023-11-02
申请号：US17801477
申请日：2022-01-11
发明人： Bo YING , Xiulian WANG
IPC分类号： C07C229/46 , C07C237/14 , C07D307/22 , C07D213/38 , C07D335/02 , C07F9/24 , C07C271/20 , C07D211/58 , C07D305/08 , C07D205/04 , C07D207/09 , A61K45/06 , A61K9/51
CPC分类号： C07C229/46 , C07C237/14 , C07D307/22 , C07D213/38 , C07D335/02 , C07F9/2458 , C07C271/20 , C07D211/58 , C07D305/08 , C07D205/04 , C07D207/09 , A61K45/06 , A61K9/5123 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , B82Y5/00
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
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公开(公告)号：US20230286902A1
公开(公告)日：2023-09-14
申请号：US17821738
申请日：2022-08-23
发明人： Bo Ying
IPC分类号： C07C229/16 , C07C229/24 , C07C233/26 , C07C237/12 , C07C271/20 , C07C275/14 , C07D205/04 , C07D207/12 , C07D211/46 , C07D211/58 , C07D305/08 , C07D307/22 , C07D309/14 , C07D335/02
CPC分类号： C07C229/16 , C07C229/24 , C07C233/26 , C07C237/12 , C07C271/20 , C07C275/14 , C07D205/04 , C07D207/12 , C07D211/46 , C07D211/58 , C07D305/08 , C07D307/22 , C07D309/14 , C07D335/02
摘要： Provided herein are lipids that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination.
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公开(公告)号：US20230277652A1
公开(公告)日：2023-09-07
申请号：US18051819
申请日：2022-11-01
发明人： Bo Ying
IPC分类号： A61K39/215 , A61P31/14
CPC分类号： A61K39/215 , A61P31/14 , A61K2039/53
摘要： Provided herein are therapeutic nucleic acid molecules for managing, preventing and/or treating infectious diseases caused by coronavirus. Also provided herein are therapeutic compositions, including vaccines and lipid nanoparticles, comprising the therapeutic nucleic acids and related therapeutic methods and uses.
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公开(公告)号：US20220331414A1
公开(公告)日：2022-10-20
申请号：US17639817
申请日：2021-06-29
发明人： Bo Ying
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipids.
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公开(公告)号：US20240269074A1
公开(公告)日：2024-08-15
申请号：US18617058
申请日：2024-03-26
发明人： Bo YING , Xiulian WANG
IPC分类号： A61K9/16 , C07C217/28 , C07C219/06 , C07C229/16 , C07C229/22 , C07C235/06 , C07D207/24 , C07D295/13
CPC分类号： A61K9/1617 , C07C217/28 , C07C219/06 , C07C229/16 , C07C229/22 , C07C235/06 , C07D207/24 , C07D295/13 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
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公开(公告)号：US20240238212A1
公开(公告)日：2024-07-18
申请号：US18558353
申请日：2023-01-18
发明人： XiuLian WANG , Bo YING
IPC分类号： A61K9/51 , A61K39/00 , C07C217/28 , C07C217/40 , C07C219/06
CPC分类号： A61K9/5123 , A61K39/0011 , C07C217/28 , C07C217/40 , C07C219/06
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
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