公开(公告)号：US11795191B2

公开(公告)日：2023-10-24

申请号：US16371646

申请日：2019-04-01

Applicant: Jingyue Ju ,  Shiv Kumar ,  Chuanjuan Tao ,  Minchen Chien ,  James J. Russo ,  John J. Kasianowicz ,  Joseph W. F. Robertson

Inventor： Jingyue Ju ,  Shiv Kumar ,  Chuanjuan Tao ,  Minchen Chien ,  James J. Russo ,  John J. Kasianowicz ,  Joseph W. F. Robertson

IPC: C12Q1/68 ,  C07H19/00 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/6869 ,  C07H19/06 ,  C07H19/16 ,  G01N33/487 ,  C12Q1/6883 ,  B82Y5/00

CPC classification number: C07H19/00 ,  C07H19/06 ,  C07H19/16 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/6869 ,  C12Q1/6883 ,  G01N33/48721 ,  B82Y5/00 ,  C12Q2600/158 ,  G01N2333/9125 ,  C12Q1/6869 ,  C12Q2521/525 ,  C12Q2521/543 ,  C12Q2537/157 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2521/525 ,  C12Q2521/543 ,  C12Q2535/107 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2565/631

Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

公开(公告)号：US11519987B2

公开(公告)日：2022-12-06

申请号：US17301509

申请日：2021-04-05

Applicant: Case Western Reserve University ,  Government of the United States, as represented by the Secretary of Commerce ,  The Regents of the University of Colorado, a body corporate

Inventor： Kathryn Keenan ,  Megan Poorman ,  Rasim Boyacioglu ,  Mark A. Griswold

IPC: G01R33/50 ,  G01R33/56 ,  A61B5/055 ,  A61B5/00 ,  G01R33/385

Abstract: A method for temperature quantification using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a region of interest in a subject using an MRF pulse sequence with smoothly varying RF phase for MR resonant frequencies that is played out continuously. For each of a plurality of time intervals during acquisition of the MRF data the method further includes comparing a set of the MRF data associated with the time interval to an MRF dictionary to determine at least one quantitative parameter of the acquired MRF data, determining a temperature change based on the at least one quantitative parameter and generating a quantitative map of the temperature change in the region of interest. The region of interest can include aqueous and adipose tissue.

公开(公告)号：US20210311146A1

公开(公告)日：2021-10-07

申请号：US17301509

申请日：2021-04-05

Applicant: Case Western Reserve University ,  Government of the United States, as represented by the Secretary of Commerce ,  The Regents of the University of Colorado, a body corporate

Inventor： Kathryn Keenan ,  Megan Poorman ,  Rasim Boyacioglu ,  Mark A. Griswold

IPC: G01R33/50 ,  G01R33/56 ,  G01R33/385 ,  A61B5/00 ,  A61B5/055

Abstract: A method for temperature quantification using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a region of interest in a subject using an MRF pulse sequence with smoothly varying RF phase for MR resonant frequencies that is played out continuously. For each of a plurality of time intervals during acquisition of the MRF data the method further includes comparing a set of the MRF data associated with the time interval to an MRF dictionary to determine at least one quantitative parameter of the acquired MRF data, determining a temperature change based on the at least one quantitative parameter and generating a quantitative map of the temperature change in the region of interest. The region of interest can include aqueous and adipose tissue.

公开(公告)号：US5963176A

公开(公告)日：1999-10-05

申请号：US843170

申请日：1997-04-14

Applicant: Frederick Solheim ,  James Jordan ,  John Wilson

Inventor： Frederick Solheim ,  James Jordan ,  John Wilson

IPC: H01Q1/52 ,  H01Q19/02 ,  H01Q19/10 ,  H01Q1/32

CPC classification number: H01Q1/526 ,  H01Q19/021 ,  H01Q19/10

Abstract: An antenna shroud or clutter fence has edge treatment for redirecting or absorbing energy which would otherwise be diffracted in an undesired direction. The edge treatment can include an array of corrugations which are about .lambda./4 deep for scattering sidelobes. The array of corrugations can be parallel to either the E-wave component or the H-wave component. Alternatively, the edge treatment can include an array of antennas encased in a dielectric extension.

Abstract translation: 天线护罩或杂波栅栏具有用于重定向或吸收能量的边缘处理，否则其将以不期望的方向衍射。 边缘处理可以包括波纹阵列，其大约为λ/ 4深以用于散射旁瓣。 波纹阵列可以平行于E波分量或H波分量。 或者，边缘处理可以包括封装在介电延伸部中的天线阵列。