公开(公告)号：US11793819B2

公开(公告)日：2023-10-24

申请号：US16104101

申请日：2018-08-16

申请人： TherapeuticsMD, Inc.

发明人： Brian A. Bernick ,  Janice Louise Cacace ,  Peter H. R. Persicaner ,  Neda Irani ,  Julia M. Amadio ,  Frederick D. Sancilio

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K9/48 ,  A61K47/14 ,  A61K9/02 ,  A61P15/00 ,  A61K47/10 ,  A61K9/107 ,  A61K9/16 ,  A61K9/70

CPC分类号： A61K31/57 ,  A61K9/1075 ,  A61K9/16 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/7023 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K31/565 ,  A61K2300/00 ,  A61K31/57 ,  A61K2300/00

摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

公开(公告)号：US11304959B2

公开(公告)日：2022-04-19

申请号：US16746434

申请日：2020-01-17

申请人： TherapeuticsMD, Inc.

发明人： Brian A. Bernick ,  Thorsteinn Thorsteinsson ,  Peter H. R. Persicaner ,  Janice Louise Cacace ,  Frederick D. Sancilio ,  Neda Irani ,  Julia Amadio

IPC分类号： A61K31/565 ,  A61K47/14 ,  A61K31/57 ,  A61K9/00

摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

公开(公告)号：US11266661B2

公开(公告)日：2022-03-08

申请号：US15781840

申请日：2016-12-07

申请人： THERAPEUTICSMD, INC.

发明人： Sebastian Mirkin ,  Julia M. Amadio ,  Brian Bernick

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K9/00 ,  A61K9/48 ,  A61K47/12 ,  A61K47/14

摘要： Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).

公开(公告)号：US20220016133A9

公开(公告)日：2022-01-20

申请号：US15781840

申请日：2016-12-07

申请人： THERAPEUTICSMD, INC.

发明人： Sebastian Mirkin ,  Julia M. Amadio ,  Brian Bernick

IPC分类号： A61K31/565 ,  A61K9/00 ,  A61K9/48 ,  A61K47/14 ,  A61K47/12

摘要： Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).

公开(公告)号：US11166963B2

公开(公告)日：2021-11-09

申请号：US15999040

申请日：2018-08-16

申请人： THERAPEUTICSMD, INC.

发明人： Brian A. Bernick ,  Janice Louise Cacace ,  Peter H. R. Persicaner ,  Neda Irani ,  Julia M. Amadio ,  Frederick D. Sancilio

IPC分类号： A61K31/57 ,  A61K31/565 ,  A61K9/48 ,  A61K47/14 ,  A61P15/02 ,  A61P5/30 ,  A61P15/00 ,  A61K47/44 ,  A61K47/10 ,  A61K9/107 ,  A61K9/00 ,  A61K9/02

摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

公开(公告)号：US11103516B2

公开(公告)日：2021-08-31

申请号：US16885094

申请日：2020-05-27

申请人： TherapeuticsMD, Inc.

发明人： Brian A. Bernick ,  Janice Louise Cacace ,  Peter H. R. Persicaner ,  Neda Irani ,  Julia M. Amadio ,  Frederick D. Sancilio

IPC分类号： A61K31/57 ,  A61K31/565 ,  A61K9/48 ,  A61K47/44 ,  A61K47/14 ,  A61K47/10 ,  A61K9/107 ,  A61K9/16 ,  A61K9/70

摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

公开(公告)号：US20200297735A1

公开(公告)日：2020-09-24

申请号：US16833186

申请日：2020-03-27

申请人： TherapeuticsMD, Inc.

发明人： Brian A. BERNICK ,  Thorsteinn THORSTEINSSON ,  Peter H.R. PERSICANER ,  Janice Louise CACACE ,  Frederick D. SANCILIO ,  Neda IRANI ,  Julia AMADIO

IPC分类号： A61K31/565 ,  A61K9/00 ,  A61K31/57 ,  A61K47/14

摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

公开(公告)号：US10537581B2

公开(公告)日：2020-01-21

申请号：US14521230

申请日：2014-10-22

申请人： TherapeuticsMD, Inc.

发明人： Brian A. Bernick ,  Thorsteinn Thorsteinsson ,  Peter H. R. Persicaner ,  Janice Louise Cacace ,  Frederick D. Sancilio ,  Neda Irani ,  Julia Amadio

IPC分类号： A61K31/565 ,  A61K9/00 ,  A61K47/14 ,  A61K31/57

摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

公开(公告)号：US10532059B2

公开(公告)日：2020-01-14

申请号：US15901467

申请日：2018-02-21

申请人： TherapeuticsMD, Inc.

发明人： Annette Shadiack ,  Peter H. R. Persicaner ,  Philip B. Inskeep ,  Thorsteinn Thorsteinsson ,  Frederick D. Sancilio ,  Jason D. Legassie

IPC分类号： A61K31/57 ,  A61K9/00 ,  A61K47/06 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44 ,  A61K47/14 ,  A61K9/48 ,  A61K31/565

摘要： This disclosure provides a novel pharmaceutical composition for delivering steroid hormones to a patient in need thereof.

公开(公告)号：US10471148B2

公开(公告)日：2019-11-12

申请号：US15454898

申请日：2017-03-09

申请人： TherapeuticsMD, Inc.

发明人： Janice Cacace ,  Peter H. R. Persicaner ,  Thorsteinn Thorsteinsson ,  Frederick Sancilio ,  Julia Amadio ,  Brian Bernick

IPC分类号： A61K9/64 ,  A61K9/00 ,  A61K31/56 ,  A61K47/14 ,  A61K31/57 ,  A61K9/48

摘要： This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.