公开(公告)号：US20190002534A1

公开(公告)日：2019-01-03

申请号：US15750716

申请日：2016-08-12

Applicant: University of Massachusetts

Inventor： William D. THOMAS, Jr. ,  Yang WANG

IPC: C07K16/10 ,  A61P31/14 ,  A61K39/205

CPC classification number: C07K16/10 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/507 ,  A61K2300/00 ,  A61P31/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2760/20121 ,  C12N2760/20134 ,  C12N2760/20171

Abstract: The invention provides human antibodies against rabies and methods of using the same.

公开(公告)号：US12297429B2

公开(公告)日：2025-05-13

申请号：US17213887

申请日：2021-03-26

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Bruno Miguel da Cruz Godinho ,  James W. Gilbert

IPC: C12N15/113 ,  C12Q1/68

Abstract: This disclosure relates to novel C9ORF72 targeting sequences. Novel sense and antisense dual-targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.

公开(公告)号：US20250145845A1

公开(公告)日：2025-05-08

申请号：US18504518

申请日：2023-11-08

Applicant: Raytheon Company ,  The University of Massachusetts

Inventor： Gavin Alexander ,  Andrew M. Luce ,  Christopher Areias ,  Craig Alfred Armiento ,  Susan C. Trulli ,  Alkim Akyurtlu ,  Oshada K. Ranasingha

IPC: C09D11/38 ,  C09D11/52

Abstract: A method of forming a convertible ink. The method includes: performing a polyol process with a metal salt, a capping agent and a solvent to produce encapsulated nanospheres in a first aqueous solution; reducing the amount of capping agent in the solution. The capping agent can be reduced by: adding solvent soluble with the capping agent and agitating the mixture via centrifugation to form a supernatant and a precipitate that includes the encapsulated nanospheres; removing the supernatant; adding a second solvent to the precipitate to form a second solution; agitating the second solution to form a second supernatant and a precipitate that includes the encapsulated nanospheres; and removing the second supernatant.

公开(公告)号：US12281132B2

公开(公告)日：2025-04-22

申请号：US18100592

申请日：2023-01-24

Applicant: University of Massachusetts

Inventor： Marcel U. Brown ,  Todd Emrick

IPC: C07F9/54 ,  C08L25/18

Abstract: The invention provides novel zwitterionic monomers and polymers (including copolymers) with pendent phosphonium-based zwitterionic moieties, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as surfactants, coatings, and interlayer materials, biomedical materials or agents.

公开(公告)号：US20250120372A1

公开(公告)日：2025-04-17

申请号：US18720575

申请日：2022-12-16

Applicant: The Jackson Laboratory ,  University of Massachusetts ,  Massachusetts Institute of Technology

Inventor： Leonard D. Shultz ,  Michael A. Brehm ,  Dale L. Greiner ,  Daniel Anderson ,  Joshua C. Doloff

IPC: A01K67/0271 ,  A01K67/0278

Abstract: The present disclosure provides, in some aspects, a humanized immunodeficient mouse model of human fibrosis. A humanized immunodeficient mouse model provided herein may be used, for example, for modeling human fibrosis, predicting human fibrosis, and testing putative fibrosis treatments.

公开(公告)号：US20250115593A1

公开(公告)日：2025-04-10

申请号：US18904487

申请日：2024-10-02

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  University of Massachusetts

Inventor： John A. PORCO, Jr. ,  Zihao WANG ,  Lauren E. BROWN ,  Stanley I. Goldstein ,  Sunll K. MALONIA ,  Ritesh P. THAKARE ,  Alok K. MISHRA ,  Michael R. Green

IPC: C07D413/12 ,  A61K31/343 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/4525 ,  A61K31/5377 ,  A61P35/00 ,  C07D307/93 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

公开(公告)号：US12265073B2

公开(公告)日：2025-04-01

申请号：US17292133

申请日：2019-11-05

Applicant: University of Massachusetts ,  The United States of America, as Represented by the Secretary of Agriculture

Inventor： Boce Zhang ,  Hengyong Yu ,  Yaguang Luo ,  Xiaobo Liu

IPC: G01N33/00 ,  G01N31/22 ,  G01N33/12 ,  G01N33/14 ,  G01N33/58

Abstract: A chromogenic assay includes a substrate comprising an array of 5 or more dyes which react with volatile organic compounds, wherein the dyes are chromogenic when reacted with volatile organic chemical biomarkers, wherein the volatile organic chemical biomarkers comprise acids, alcohols, aldehydes, alkenes, amines, antioxidants, aromatic compounds, esters, ethylene, lactones, ketones, organosulfur compounds, sulfides, reactive oxygen species, terpenes, or a combination thereof. A method of detecting volatile organic chemical biomarkers includes contacting the chromogenic assay with a sample or sample headspace, wherein the sample or sample headspace is suspected of containing volatile organic chemical biomarkers, and identifying, based on a colorimetric pattern on the chromogenic assay after contacting, the source of the volatile organic chemical biomarkers. Also included are articles and systems including the chromogenic assay.

公开(公告)号：US12252703B2

公开(公告)日：2025-03-18

申请号：US17335499

申请日：2021-06-01

Applicant: University of Massachusetts ,  Voyager Therapeutics, Inc.

Inventor： Robert M. Kotin ,  Sylvain Cecchini

IPC: C12N15/86 ,  A61K48/00 ,  A61P1/16 ,  A61P3/00 ,  A61P3/08 ,  A61P7/04 ,  A61P11/12 ,  A61P27/02 ,  C07K14/005 ,  C12N15/09 ,  C12N15/63 ,  C12N15/64 ,  C12N15/66

Abstract: Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.

公开(公告)号：US12242169B2

公开(公告)日：2025-03-04

申请号：US18128532

申请日：2023-03-30

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Peter DiMeo ,  Jingyang Yan ,  Xian Du

IPC: G03B13/36 ,  G03B3/10 ,  H04N23/61

Abstract: Various examples are provided related to high-speed autofocus control. In one example, a method includes obtaining a first image of a target with a camera; adjusting focus of the camera by a specified AF bin step size; obtaining a second image of the target; adjusting focus of the camera by the specified AF bin step size; obtaining a third image of the target; determining an optimal focus using data of the second and third images; and adjusting focus of the camera to the optimal focus. In another example, a method includes generating an input vector comprising a sequence of input-output pairs associated with a piezoelectric controlled motion stage that can position a camera relative to a target; determine a control input for the motion stage using a LSTM backpropagation network trained to minimize a cost function over a defined prediction horizon; and applying the control input to the motion stage.

公开(公告)号：US20250068063A1

公开(公告)日：2025-02-27

申请号：US18942155

申请日：2024-11-08

Applicant: University of Massachusetts

Inventor： James J. Watkins ,  Feyza Dundar Arisoy ,  Irene R. Howell ,  Vincent Einck

IPC: G03F7/00 ,  H01M4/04 ,  H01M6/40

Abstract: Various examples disclosed relate to a method of manufacturing a mechanically stabilized material that includes a nanostructure. The method includes providing a curable material disposed on a substrate. The curable material includes inorganic nanoparticles. The method further includes exposing the curable material and the substrate to pulsed electromagnetic radiation to form the mechanically stabilized material.