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公开(公告)号：US20240198014A1
公开(公告)日：2024-06-20
申请号：US18286982
申请日：2022-04-14
发明人： Michael SULLIVAN , Zachary WALLACE , Lawton LAURENCE , Lauren NUTT , Nicholas CICCARELLI , Shaun DEVITT
CPC分类号： A61M5/326 , A61M5/2033 , A61M5/3202 , A61M5/322
摘要： An assembly for an injection device is described. The assembly includes a container containing the medicament and having a cap. The container is sealed by a septum. A sealing element is in contact with an external surface of the cap and a needle is provided for piercing the septum. A needle hub is attached to the needle, where the sealing element is disposed between the external surface of the cap of the container and an internal surface of the needle hub. The assembly transitions from a first state, in which the needle is held away from the septum and a free end of the needle sits in a cavity sealed by the sealing element, to a second state, in which the needle passes through the septum. The seal is maintained throughout transition and when the assembly is in the second state.
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公开(公告)号：US20240198013A1
公开(公告)日：2024-06-20
申请号：US18286979
申请日：2022-04-14
发明人： Lawton LAURENCE , Lauren NUTT , Jeff THAWLEY
CPC分类号： A61M5/3245 , A61M5/2033 , A61M5/3275 , A61M5/3293 , A61M2207/10
摘要： An injection device includes a housing defining a longitudinal axis and receiving a medicament container containing a medicament. The housing has a distal end which defines an opening for receiving a portion of a needle operably coupled with the medicament container. A safety shield surrounds at least a distal portion of the housing. The safety shield advances distally relative to the housing from a retracted position to a deployed position for shielding the needle. An advancement spring is arranged between the housing and the safety shield. The advancement spring advances the safety shield from the retracted position to the deployed position, and interlocks with the housing and the safety shield when the safety shield is in the deployed position to prevent return of the safety shield to the retracted position.
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公开(公告)号：US11951289B2
公开(公告)日：2024-04-09
申请号：US17828046
申请日：2022-05-31
发明人： Jeffrey M. Laubach , Jurgen Brinkhues , Heike Gruen , Joel Worman , Xia Zhao , Jason Mattia
IPC分类号： A61M5/315
CPC分类号： A61M5/31513 , A61M2205/0222
摘要： A piston having a longitudinal axis and opposing proximal and distal axial ends is manufactured by a method including molding a partially formed piston body and then molding the piston. The partially formed piston body is molded by placing a first rubber sheet and an inert film between die plates of a first forming tool, vulcanizing the first rubber sheet and the inert film between the die plates of the first forming tool, and blanking out the partially formed piston body from the first rubber sheet and the inert film. The piston is then molded by placing the partially formed piston body into a second forming tool, placing a second rubber sheet into the second forming tool, vulcanizing the second rubber sheet and the partially formed piston body together, and blanking out the piston from the second rubber sheet at a trim edge spaced apart from the inert film.
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公开(公告)号：US11679206B2
公开(公告)日：2023-06-20
申请号：US16755952
申请日：2018-10-22
发明人： Kevin Stevens , Ian Scrimgeour , Scott Salter , Andrew Blair , Alan Kitching , David Sheperd
CPC分类号： A61M5/3157 , A61M5/002 , A61M5/3204 , A61M2205/18 , A61M2205/581 , A61M2205/584
摘要： An injection system includes a handle assembly with a handle body having an outer surface surrounding a handle body interior and a plunger extending therethrough. A tubular handle collar is telescopically received in the handle body exterior and is axially movable with respect to the handle body. A syringe housing assembly is selectively connectable to the handle assembly and includes a syringe housing and a tubular syringe sleeve telescopically received through a distal end of the syringe housing and axially movable with respect thereto. The syringe housing has an exterior side surface surrounding a syringe housing interior configured to receive at least a portion of a syringe. The syringe sleeve has a proximal end, a distal end with a skin contact surface, and a generally cylindrically-shaped outer surface.
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公开(公告)号：US20230064423A1
公开(公告)日：2023-03-02
申请号：US17799608
申请日：2021-02-08
摘要： Various systems for the containment or delivery of a product are provided. The systems allow for the storage of products at low temperatures and include a container closure inserted into a container (10). The container closure may have an elastomeric body (12) and include a material (14) having a negative coefficient of thermal expansion. In other systems, the material having a negative coefficient of thermal expansion may be inserted between the elastomeric container closure and a seal. Other systems may include an insert at least partially embedded within the elastomeric body of a container closure, an actuator having a distal end movably attached to the insert, and a resilient element between the distal end of the actuator and the insert, wherein the resilient material expands radially upon displacing the distal end of the actuator toward the insert.
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公开(公告)号：US20220288320A1
公开(公告)日：2022-09-15
申请号：US17828046
申请日：2022-05-31
发明人： Jeffrey M. LAUBACH , Jurgen BRINKHUES , Heike GRUEN , Joel WORMAN , Xia ZHAO , Jason MATTIA
IPC分类号： A61M5/315
摘要： A piston having a longitudinal axis and opposing proximal and distal axial ends is manufactured by a method including molding a partially formed piston body and then molding the piston. The partially formed piston body is molded by placing a first rubber sheet and an inert film between die plates of a first forming tool, vulcanizing the first rubber sheet and the inert film between the die plates of the first forming tool, and blanking out the partially formed piston body from the first rubber sheet and the inert film. The piston is then molded by placing the partially formed piston body into a second forming tool, placing a second rubber sheet into the second forming tool, vulcanizing the second rubber sheet and the partially formed piston body together, and blanking out the piston from the second rubber sheet at a trim edge spaced apart from the inert film.
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公开(公告)号：US20220227113A1
公开(公告)日：2022-07-21
申请号：US17713920
申请日：2022-04-05
发明人： Jason KRIZAN , Douglas R. DURIEZ , Liang FANG , Kerry DRAKE
IPC分类号： B32B38/10 , A61M5/315 , B29C43/00 , B29C43/02 , B32B27/08 , B32B27/26 , B32B27/30 , B32B37/26 , B29C65/70 , B29C43/20 , B32B37/00 , B29C65/00
摘要： An elastomeric article for sealing a container includes an elastomeric body having an external sidewall surface and an external crown surface and a first fluoropolymer film layer having an internal surface and an external surface. The internal surface of the first fluoropolymer film layer is laminated to an entirety of the external sidewall and crown surfaces of the elastomeric body. The external crown surface of the first fluoropolymer film layer includes a drug contact surface configured to contact a drug contained in the container and the external sidewall surface including a sealing surface for contacting an interior surface of the container. The external surface of the first fluoropolymer film layer is substantially free of striations.
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公开(公告)号：US11369742B2
公开(公告)日：2022-06-28
申请号：US16354675
申请日：2019-03-15
发明人： Jeffrey M. Laubach , Jurgen Brinkhues , Heike Gruen , Joel Worman , Xia Zhao , Jason Mattia
IPC分类号： A61M5/315
摘要： A pharmaceutical syringe piston having a longitudinal axis includes a body having a central face portion with a first outer circumference and maximum first diameter. A cylindrical sealing portion proximate the central face portion has first and second axial ends and a wall extending therebetween. The wall has a second outer circumference and a second diameter essentially constant along the longitudinal axis between the first and second axial ends of the cylindrical sealing portion and is larger than the maximum first diameter. An annular curved portion has a maximum outer diameter less than the second diameter and connects the first axial end of the cylindrical sealing portion to the first outer circumference. An inert film encloses the central face portion and at least part of the annular curved portion and has an outer boundary between the first axial end of the cylindrical sealing portion and the first outer circumference.
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公开(公告)号：US20220187155A1
公开(公告)日：2022-06-16
申请号：US17425778
申请日：2020-01-25
摘要： Systems and methods for determining Container Closure Integrity (CCI) in a container system comprising a container, an elastomeric stopper, and a retainer for retaining the stopper in place are disclosed. The systems and methods involve disposing, within a seal assembly, a component configured to sense a degree of compression of the elastomeric stopper. In a first implementation, the elastomeric stopper comprises an embedded positioning component embedded within the elastomeric material. The position of the positioning component is sensed using a detection system and the integrity of the closure is determined based on the position of the embedded component. In a second implementation, a force sensitive resistor is disposed within the seal stack to measure the compression of the elastomeric stopper. The compression of the elastomeric stopper is correlated to the integrity of the seal.
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10.发明授权公开(公告)号：US11280695B2
公开(公告)日：2022-03-22
申请号：US17296524
申请日：2019-11-25
发明人： Louis J. Brasten , James McCaw
IPC分类号： G01M3/22
摘要： A system for testing the closure integrity of a sealed container at a cryogenic temperature is provided. The system includes a sealed container containing helium having an opening sealed by a closure, a cryogenic storage vessel at least partially filled with a cryogenic fluid at the cryogenic temperature, a hollow tube extending through an opening of the cryogenic storage vessel, a fixture configured to engage the sealed container, and a leak detection unit connected to the hollow tube. The hollow tube has a first end positioned outside of the cryogenic storage vessel and an opposing second end positioned inside the cryogenic storage vessel. The fixture is configured to be removably inserted within the hollow tube through an opening at the first end of the hollow tube, such that the sealed container is positioned at or proximate the second end of the hollow tube.
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