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公开(公告)号：US20230158101A1
公开(公告)日：2023-05-25
申请号：US18151155
申请日：2023-01-06
Applicant: Xellia Pharmaceuticals APS
Inventor： Ivona Jasprica , Sabina Keser , Katarina Pindric
CPC classification number: A61K38/14 , A61K9/0019 , A61K47/183 , A61K9/08
Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as an N-acetyl amino acid are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl amino acids.
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公开(公告)号：US20220354927A1
公开(公告)日：2022-11-10
申请号：US17860642
申请日：2022-07-08
Applicant: Xellia Pharmaceuticals ApS
Inventor： Ivona Jasprica , Sabina Keser , Katarina Pindric
Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
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公开(公告)号：US09393307B2
公开(公告)日：2016-07-19
申请号：US14547742
申请日：2014-11-19
Applicant: Xellia Pharmaceuticals ApS
Inventor： Swapnil P. Shirode , Piyush Patel , Suresh Gidwani , Neil Parikh , Atul Patil , Anita Bevetek Mochnik
IPC: A01N37/18 , A61K38/00 , A61P31/10 , A61K47/12 , A61K9/00 , A61K9/19 , A61K38/12 , A61K47/10 , A61K47/26
Abstract: The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.
Abstract translation: 本发明涉及包含卡泊芬净或其药学上可接受的盐和作为缓冲剂的琥珀酸盐或乳酸盐的组合物。
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公开(公告)号：US09005990B2
公开(公告)日：2015-04-14
申请号：US13504485
申请日：2010-09-29
Applicant: Torben Koch , Carsten Overblle Petersen
Inventor： Torben Koch , Carsten Overblle Petersen
CPC classification number: C07K7/62 , Y10T436/25 , Y10T436/25375
Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
Abstract translation: 本发明涉及一种使用反相色谱法纯化粘菌素的方法，其中在乙酸和乙醇浓度较高的乙醇浓度下加入具有粘菌素碱的柱，并以低乙醇浓度洗脱。
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5.发明授权公开(公告)号：US08598131B2
公开(公告)日：2013-12-03
申请号：US13178930
申请日：2011-07-08
Applicant: Thomas Norling
Inventor： Thomas Norling
CPC classification number: A61M11/02 , A61K9/0078 , A61K31/7036 , A61M15/0065 , A61M15/0091
Abstract: The present invention regards a novel administration form and a novel administration regime useful in the treatment and prevention of a bacterial lung infection in patient in need thereof, in particular by providing a composition useful for aerosolization of a highly concentrated solution of aminoglycosides such as Tobramycin.
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Patent Agency Ranking
公开(公告)号：US08410044B2
公开(公告)日：2013-04-02
申请号：US13502142
申请日：2010-09-30
Applicant: Martin Mansson , Christine Senstad
Inventor： Martin Mansson , Christine Senstad
Abstract: The invention concerns new Bacitracin compounds containing methylene-isoleucine.
Abstract translation: 本发明涉及含有亚甲基异亮氨酸的新的杆菌肽化合物。
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公开(公告)号：US20120142893A1
公开(公告)日：2012-06-07
申请号：US13389597
申请日：2010-08-11
Applicant: Anders Brunsvik
Inventor： Anders Brunsvik
CPC classification number: C07K1/20 , A61K38/00 , B01D15/305 , B01D15/322 , B01D15/364 , B01D15/426 , C07K7/56 , C07K7/64
Abstract: The present invention concerns a method for separation of the antifungal cyclic hexapeptides Pneumocandin B0 from Pneumocandin C0 using a hydrophilic stationary phase and a hydrophobic mobile phase.
Abstract translation: 本发明涉及使用亲水性固定相和疏水性流动相从肺炎球菌C0分离抗真菌环状六肽肺炎衣霉素B0的方法。
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公开(公告)号：US07981859B2
公开(公告)日：2011-07-19
申请号：US10944601
申请日：2004-09-17
Applicant: Anita Mathiesen , Torben Koch , Tiemen Geert Pieter Reijns , Gerd Trine Suhr-Jessen , Jørn Thyme
Inventor： Anita Mathiesen , Torben Koch , Tiemen Geert Pieter Reijns , Gerd Trine Suhr-Jessen , Jørn Thyme
CPC classification number: A61K38/14
Abstract: A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
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公开(公告)号：US07868191B2
公开(公告)日：2011-01-11
申请号：US12310216
申请日：2007-08-29
Applicant: Lene Aassveen
Inventor： Lene Aassveen
IPC: C07D407/06
CPC classification number: C07D407/06
Abstract: The present invention relates to methods for the preparation and purification of mupirocin calcium. The process comprises adsorbing mupirocin to a hydrophobic adsorbent resin, exposing the bound mupirocin to a calcium-containing solution, washing impurities from the resin and eluting purified mupirocin calcium from the resin.
Abstract translation: 本发明涉及制备和纯化莫匹罗星钙的方法。 该方法包括将莫匹罗星吸附到疏水性吸附树脂上，将结合的莫匹罗星暴露于含钙溶液中，从树脂中洗涤杂质并从树脂洗脱纯化的莫匹罗星钙。
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公开(公告)号：US12070485B2
公开(公告)日：2024-08-27
申请号：US18484819
申请日：2023-10-11
Applicant: Xellia Pharmaceuticals ApS
Inventor： Martina Manenica , Ema Kovacevic , Ernest Mestrovic
Abstract: The present disclosure relates to a stable aqueous composition of dalbavancin, the process for making such compositions and use of such compositions for treatment of a patient in need thereof.
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