公开(公告)号：US20240308978A1

公开(公告)日：2024-09-19

申请号：US18271192

申请日：2022-01-07

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  C07D401/12 ,  C07D471/04

CPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  C07D401/12 ,  C07D471/04

摘要： This disclosure features chemical entities of Formula I (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20240083895A1

公开(公告)日：2024-03-14

申请号：US18116183

申请日：2023-03-01

申请人： IFM Due, Inc.

发明人： William R. Roush ,  Shankar Venkatraman ,  Gary Glick ,  Hans Martin Seidel

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20230365553A1

公开(公告)日：2023-11-16

申请号：US18015856

申请日：2021-07-15

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D471/04 ,  C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/10 ,  C07D403/14 ,  C07D209/40 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D471/04 ,  C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/10 ,  C07D403/14 ,  C07D209/40 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20230250060A1

公开(公告)日：2023-08-10

申请号：US18095717

申请日：2023-01-11

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D209/40 ,  C07D413/12 ,  C07D403/14 ,  C07D405/12 ,  C07D403/12 ,  C07D417/12

CPC分类号： C07D209/40 ,  C07D413/12 ,  C07D403/14 ,  C07D405/12 ,  C07D403/12 ,  C07D417/12

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20230047905A1

公开(公告)日：2023-02-16

申请号：US17294965

申请日：2019-11-19

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D209/40 ,  C07D471/04 ,  C07D487/04 ,  C07D403/10 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07D237/04 ,  C07D261/16 ,  C07D513/04 ,  C07D495/04 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/12 ,  C07D491/052 ,  A61K45/06 ,  A61K31/404 ,  A61K31/519 ,  A61K31/437 ,  A61K31/506 ,  A61K31/407 ,  A61K31/438 ,  A61K31/4748 ,  A61K31/4178 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/415 ,  A61K31/429 ,  A61K31/4439 ,  A61K31/428 ,  A61K31/454 ,  A61K31/4353

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20230002320A1

公开(公告)日：2023-01-05

申请号：US17766095

申请日：2020-10-02

申请人： IFM Due, Inc.

发明人： Hans Martin Seidel ,  William R. Roush ,  Jason Katz ,  Shankar Venkatraman

IPC分类号： C07D209/40 ,  C07D403/10 ,  C07D401/14 ,  C07D401/10 ,  C07D405/10 ,  C07D409/10

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or prodrug, and/or tautomer, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same. Formula (I).

公开(公告)号：US20240101556A1

公开(公告)日：2024-03-28

申请号：US18271181

申请日：2022-01-07

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： This disclosure features compounds of Formula I (and their pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said compounds are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20240100017A1

公开(公告)日：2024-03-28

申请号：US18265762

申请日：2021-12-21

申请人： IFM Due, Inc.

发明人： Gary Glick ,  Anthony William Opipari, Jr. ,  Hans Martin Seidel

IPC分类号： A61K31/397 ,  A61K31/167 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/437 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/5377 ,  G01N33/68

CPC分类号： A61K31/397 ,  A61K31/167 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/437 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/5377 ,  G01N33/6893 ,  G01N2800/52

摘要： Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a cGAS inhibitor or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having decreased SMARCB1 level and/or activity in a tumor sample obtained from the subject as compared to a reference level.

公开(公告)号：US20240083879A1

公开(公告)日：2024-03-14

申请号：US18271186

申请日：2022-01-07

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D403/04 ,  C07D403/14 ,  C07D405/14

CPC分类号： C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US20240060982A1

公开(公告)日：2024-02-22

申请号：US18266180

申请日：2021-12-21

申请人： IFM Due, Inc.

发明人： Gary Glick ,  Anthony William Opipari, Jr. ,  Hans Martin Seidel

IPC分类号： G01N33/574 ,  A61K45/06

CPC分类号： G01N33/57484 ,  A61K45/06 ,  G01N2800/52

摘要： Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a cGAS inhibitor or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having decreased ATM level and/or activity in a tumor sample obtained from the subject as compared to a reference level.