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    FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS
    1.
    发明公开
    FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS 审中-公开

    公开(公告)号：US20240115742A1

    公开(公告)日：2024-04-11

    申请号：US18460519

    申请日：2023-09-01

    Applicant: New York University

    Inventor： Jin Kim Montclare ,  Dustin Britton ,  Youssef Zaim Wadghiri ,  Farbod Mahmoudinobar

    IPC: A61K49/18 ,  A61K49/14 ,  A61K49/22 ,  C07K14/245 ,  G01N24/08 ,  G01N29/34 ,  G16B40/00

    CPC classification number: A61K49/1884 ,  A61K49/14 ,  A61K49/222 ,  C07K14/245 ,  G01N24/08 ,  G01N29/34 ,  G16B40/00 ,  B82Y40/00

    Abstract: Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (LTF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence:



    VX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25X26X27X28X29X30X31X32X33X34X35X36X37 (SEQ ID NO:1), where X1 is A, E, D, R, H, K, Q, N, or S; X2 is A, E, N, or Q; X3 is A, V, L, I, Q, M, or LT; X4 is A, E, R, D, H, I, L, T, K, Q, N, or LT; X5 is A, F, Q, R, K, H, D, S, or E; X6 is A, L, I, or LTF; X7 is A, K, or E; X8 is A, K, E, D, R, H, Q, or N; X9 is A, T, I, L, Q, or LTF; X10 is A, L, I, or LT; X11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X12 is A, Q, H, E, D, K, R, or N; X13 is A, M, I, L, Q, T, or LTF; X14 is A, L, D, E, K, I, or LTF; X15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X16 is A, E, or Q; X17 is A, L, M, I, V, or LTF; X18 is A, K, E, D, K, R, H, N, or Q; X19 is A, N, D, K, R, H, Q, or E; X20 is A, L, T, I, M, R, or LTF; X21 is A, N, or Q; X22 is K, A, E, I, L, M, R, H, D, Q, N, S, or LTF; X23 is A, Q, N, I, L, or LTF; X24 is A, L, I, M, T, or LT; X25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X26 is A, D, E, R, K, Q, H, N, or T; X27 is A, V, I, Q, L, T, or LTF; X28 is A, R, E, D, K, H, N, Q, or T; X29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or LTF; X30 is L, A, D, K, I, N, Q, or LTF; X31 is A, L, Q, I, or LTF; X32 is E, D, K, H, N, Q, A, L, R, I, Y, or LTF; X33 is A, N, Q, D, E, H, K, R, or S; X34 is Q, I, L, A, M, or LT; X35 is S, A, P, or Q; X36 is A, K, T, D, R, H, N, Q, or E; X37 is A, L, I, K, D, N, Q, R, or LTF; where at least one of X3, X4, X6, X9, X10, X11, X13, X14, X15, X16, X17, X20, X22, X23, X24, X25, X27, X29, X30, X31, X32, X34, X37 or any L is replaced with LTF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to deliver drugs and/or as theranostic agents.

    Nitric oxide-releasing nanorods and their methods of use
    2.
    发明授权
    Nitric oxide-releasing nanorods and their methods of use 有权
    一氧化氮释放纳米棒及其使用方法

    公开(公告)号：US09187501B2

    公开(公告)日：2015-11-17

    申请号：US14011488

    申请日：2013-08-27

    Applicant: The University of North Carolina at Chapel Hill

    Inventor： Mark H. Schoenfisch ,  Yuan Lu

    IPC: A61K9/14 ,  C07F7/08 ,  A61K49/18 ,  A61K47/48 ,  A01N59/00 ,  B82Y5/00

    CPC classification number: C07F7/0834 ,  A01N59/00 ,  A61K47/6925 ,  A61K49/1884 ,  B82Y5/00 ,  Y10T428/2975 ,  A01N25/08 ,  A01N25/18

    Abstract: In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.

    Abstract translation: 在一个方面，本文公开的主题涉及具有期望的纵横比的NO释放功能化纳米棒。 纳米棒也能够释放所需量的NO（一氧化氮）。 在另一方面，本文公开的主题涉及包含释放NO释放纳米棒的组合物。 在另一方面，本文公开的主题涉及制备具有特定纵横比的释放NO释放纳米棒的方法。 在另一方面，本文公开的主题涉及抗感染的方法，包括向受试者施用包含释放NO释放纳米棒的组合物，其中所述纳米棒具有特定的长宽比和NO释放曲线。

    ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS
    6.
    发明申请
    ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS 审中-公开
    ROD形成的植物病毒纳米粒子作为成像剂平台

    公开(公告)号：US20150265729A1

    公开(公告)日：2015-09-24

    申请号：US14434435

    申请日：2013-10-09

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： Nicole Steinmetz

    IPC: A61K49/18 ,  C12N7/00

    CPC classification number: A61K49/1896 ,  A61K49/1884 ,  C12N7/00 ,  C12N2770/00031

    Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.

    Abstract translation: 描述了具有内表面和外表面的杆状植物病毒，以及连接到内表面和/或外表面的至少一种成像剂。 杆状病毒可以组合成较大的球形纳米粒子。 包括成像剂的棒状植物病毒或球形纳米粒子可以用于通过向受试者施用病毒颗粒来产生受试者例如肿瘤或动脉粥样硬化组织的组织区域的图像的方法，并产生图像 已分发病毒颗粒的受试者的组织区域。

    NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE
    7.
    发明申请
    NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE 有权
    氮氧化物释放纳米体系及其使用方法

    公开(公告)号：US20140065200A1

    公开(公告)日：2014-03-06

    申请号：US14011488

    申请日：2013-08-27

    Applicant: The University of North Carolina at Chapel Hill

    Inventor： Mark H. Schoenfisch ,  Yuan Lu

    IPC: C07F7/08

    CPC classification number: C07F7/0834 ,  A01N59/00 ,  A61K47/6925 ,  A61K49/1884 ,  B82Y5/00 ,  Y10T428/2975 ,  A01N25/08 ,  A01N25/18

    Abstract: In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.

    Abstract translation: 在一个方面，本文公开的主题涉及具有期望的纵横比的NO释放功能化纳米棒。 纳米棒也能够释放所需量的NO（一氧化氮）。 在另一方面，本文公开的主题涉及包含释放NO释放纳米棒的组合物。 在另一方面，本文公开的主题涉及制备具有特定纵横比的释放NO释放纳米棒的方法。 在另一方面，本文公开的主题涉及抗感染的方法，包括向受试者施用包含释放NO释放纳米棒的组合物，其中所述纳米棒具有特定的长宽比和NO释放曲线。

    COMPOSITIONS AND METHODS OF MAKING NON-SPHERICAL MICRO- AND NANO-PARTICLES
    8.
    发明申请
    COMPOSITIONS AND METHODS OF MAKING NON-SPHERICAL MICRO- AND NANO-PARTICLES 审中-公开
    制备非球形微米和纳米颗粒的组合物和方法

    公开(公告)号：US20090196826A1

    公开(公告)日：2009-08-06

    申请号：US12336876

    申请日：2008-12-17

    Applicant: Jinming Gao ,  Wenchuang Hu ,  Mukti N. Aryal ,  Fatih Buyukserin ,  Xiao-Mei Zhao

    Inventor： Jinming Gao ,  Wenchuang Hu ,  Mukti N. Aryal ,  Fatih Buyukserin ,  Xiao-Mei Zhao

    IPC: A61K49/18 ,  A61K9/00

    CPC classification number: A61K9/5146 ,  A61K9/0009 ,  A61K9/5153 ,  A61K9/5192 ,  A61K47/6907 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/0002 ,  A61K49/0095 ,  A61K49/1809 ,  A61K49/1884 ,  B82Y5/00

    Abstract: The present invention includes compositions, methods and pharmaceutical compositions formed by template-directed polymer molding by contacting a porous template with one or more layers of polymeric material coated on a release layer coated on a substrate, applying pressure to the porous template, the substrates or both and separating the porous template from the polymer material to form one or more polymer nonspherical nanostructures with one or more layers on the substrate. The template includes one or more nonspherical nanostructure features. The size and shape of the one or more single- or multi-layer polymeric nonspherical nanostructures are controlled by the one or more nonspherical nanostructure features and the polymer material optionally including one or more active agents with or without retardants, dyes, etc.

    Abstract translation: 本发明包括通过模板指导的聚合物模制而形成的组合物，方法和药物组合物，所述组合物，方法和药物组合物通过使多孔模板与涂覆在涂覆在基材上的剥离层上的一层或多层聚合材料接触，向多孔模板， 并且将多孔模板与聚合物材料分离以形成在衬底上具有一层或多层的一个或多个聚合物非球形纳米结构。 该模板包括一个或多个非球形纳米结构特征。 一个或多个单层或多层聚合物非球形纳米结构的尺寸和形状由一个或多个非球形纳米结构特征控制，并且聚合物材料任选地包括一种或多种具有或不具有阻滞剂，染料等的活性剂。

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