公开(公告)号：US20230241601A1

公开(公告)日：2023-08-03

申请号：US18043368

申请日：2021-09-06

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Erika SAWANO ,  Yuki TAKASE ,  Haruka SAKAI ,  Hideo TASHIRO ,  Tomoko TASHIRO

IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N33/563

CPC分类号： B01L3/5027 ,  G01N33/543 ,  G01N33/563 ,  B01L2300/0819 ,  G01N2474/00

摘要： A biochip is described having a substrate that has disposed on a surface at least one spot containing a complex between a solid carrier modified by a reactive group and a substance to be immobilized that has been modified via a spacer by a group that reacts with the reactive group. A method for producing the biochip and a method for detecting a target substance using the biochip are also described.

公开(公告)号：US20230313033A1

公开(公告)日：2023-10-05

申请号：US18025408

申请日：2021-09-09

申请人： Alma Mater Studiorum Università di Bologna

发明人： Luca Prodi ,  Francesco Paolucci ,  Giovanni Valenti ,  Enrico Rampazzo ,  Massimo Marcaccio ,  Damiano Genovese

IPC分类号： C09K11/06 ,  G01N33/543 ,  B82Y15/00 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： C09K11/06 ,  G01N33/54346 ,  B82Y15/00 ,  B82Y40/00 ,  B82Y5/00 ,  G01N2474/00

摘要： It is described a silica nanoparticle comprising: a) a silicate network core with a diameter in a range from 10 nm to 500 nm, preferably from 20 nm to 250 nm, wherein at least a luminophore (dye) is confined in the said silicate network core, or covalently linked to the silicate network of the core because said luminophore (dye) has an anchoring moiety able to form at least a covalent link with the silicate network core, b) a shell layer over the silicate network core a) incorporating dye/s, said shell layer b) with a thickness from 0.5 to 7 nm, preferably from 0.5 to 6 nm, more preferably from 1 to 5 nm, comprising colloidal stabilizer agent/s, selected from the group comprising: sterical or electrostatic antifouling agents or polyether antifouling agents.

公开(公告)号：US20230204582A1

公开(公告)日：2023-06-29

申请号：US17999542

申请日：2021-05-21

申请人： CYTOBAY INC.

发明人： Wenjiang Chu ,  Jian Wang

IPC分类号： G01N33/574 ,  G01N1/30

CPC分类号： G01N33/57407 ,  G01N1/30 ,  G01N2474/00

摘要： Disclosed herein are in vitro methods of multiple staining and slide preparation for a cytopathological sample, such as a urine sample. These methods enable simultaneous staining of biomarkers and cytopathological stains to greatly enhance confidence in identifying atypical cells such as cancer cells. Also disclosed herein are methods of using said staining and preparation methods for the detection of bladder cancer using urine samples from a patient. These methods offer increased sensitivity and specificity over conventional bladder cancer detection methods. Also disclosed herein are the urinary exfoliated cells stained according to the methods provided herein.

公开(公告)号：US20240159746A1

公开(公告)日：2024-05-16

申请号：US18548444

申请日：2022-02-28

申请人： MESO SCALE TECHNOLOGIES, LLC.

发明人： Michael TSIONSKY ,  John KENTEN

IPC分类号： G01N33/543 ,  G01N33/58

CPC分类号： G01N33/54306 ,  G01N33/582 ,  G01N2458/10 ,  G01N2458/30 ,  G01N2474/00

摘要： Described herein are methods, systems and kits for conducting an assay for one or more analytes of interest in a sample. In one aspect, a method is provided for conducting a multiplexed binding assay for a plurality of analytes of interest in a sample. In one aspect, the assay includes an analyte binding step and a detection step. In one aspect, the analyte binding step is separated from the detection step.

公开(公告)号：US20240027443A1

公开(公告)日：2024-01-25

申请号：US18475107

申请日：2023-09-26

申请人： CANON KABUSHIKI KAISHA

发明人： KENGO KANAZAKI ,  FUMIO YAMAUCHI ,  NORISHIGE KAKEGAWA ,  MASARU SUGITA ,  RYO NATORI ,  TAKESHI MURAKAMI

IPC分类号： G01N33/547 ,  G01N33/531 ,  C08F212/08

CPC分类号： G01N33/547 ,  G01N33/531 ,  C08F212/08 ,  G01N2474/00 ,  C08F2810/50

摘要： A particle including a polymer which has a repeating unit derived from a vinyl-based monomer. The particle has a specific structure containing a carboxy group, and a surface of the particle contains a water-soluble polymer.