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公开(公告)号:US12005704B2
公开(公告)日:2024-06-11
申请号:US16414752
申请日:2019-05-16
Applicant: Catalog Technologies, Inc.
Inventor: Nathaniel Roquet , Hyunjun Park , Swapnil P. Bhatia , Mike Hazell , Richard Day , Richard Hammond , James Brown , Rodney Richardson , Thomas Redman , Devin Leake
CPC classification number: B41J2/04505 , B41J2/04526 , B41J2/05 , B41J2/1652 , C12P19/34 , G06N3/123
Abstract: Provided herein are systems and methods for storing digital information by assembling an identifier nucleic acid molecule from at least a first component nucleic acid molecule and a second component nucleic acid molecule. The system may include a first printhead configured to dispense a first droplet of a first solution comprising the first component nucleic acid molecule onto a coordinate on a substrate, and a second printhead configured to dispense a second droplet of a second solution comprising the second component nucleic acid molecule onto the coordinate on the substrate, such that the first and second component nucleic acid molecules are collocated on the substrate. The system may include a finisher that dispenses a reaction mix onto the coordinate on the substrate to physically link the first and second component nucleic acid molecules, provides a condition necessary to physically link the first and second component nucleic acid molecules, or both.
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公开(公告)号:US20240095543A1
公开(公告)日:2024-03-21
申请号:US18233855
申请日:2023-08-14
Inventor: Daniella Bar-Lev , Itai Orr , Omer Sabary , Tuvi Etzion , Eitan Yaakobi
Abstract: A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.
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公开(公告)号:US20240013063A1
公开(公告)日:2024-01-11
申请号:US18230273
申请日:2023-08-04
Applicant: CATALOG TECHNOLOGIES, INC.
Inventor: Nathaniel Roquet , Hyunjun Park , Swapnil P. Bhatia , Darren R. Link
CPC classification number: G06N3/123 , G06F16/245 , G06F16/2272 , G16B30/00 , G16B50/00 , G16B30/20 , C12N9/22
Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).
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公开(公告)号:US20230385653A1
公开(公告)日:2023-11-30
申请号:US17752203
申请日:2022-05-24
Applicant: AT&T Intellectual Property I, L.P.
Inventor: Mukundan Sarukkai , Eshrat Huda
Abstract: Aspects of the subject disclosure may include, for example, a device having a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations, including: selecting a first building block pattern function (bbDNA) having a first weight from a catalog, wherein the first bbDNA is based on a first mature pattern reaching a first bbDNA frequency threshold, wherein the first bbDNA is associated with at least one machine learning (ML) model of a plurality of ML models; selecting a second bbDNA having a second weight from the catalog, wherein the second bbDNA is associated with at least one ML model in the plurality of ML models; and creating a new ML model based on a combination of the first bbDNA and the second bbDNA. Other embodiments are disclosed.
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公开(公告)号:US20230376788A1
公开(公告)日:2023-11-23
申请号:US18230385
申请日:2023-08-04
Applicant: Catalog Technologies, Inc.
Inventor: Nathaniel Roquet , Hyunjun Park , Swapnil P. Bhatia
CPC classification number: G06N3/123 , G06F5/08 , C12N9/22 , C12N2310/20 , G16B20/00
Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).
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公开(公告)号:US11823065B2
公开(公告)日:2023-11-21
申请号:US17334191
申请日:2021-05-28
Applicant: Bank of America Corporation
Inventor: Manmohan Singh , Shantanu Singh , Vineet Kumar Upadhyay , Madhusudhanan Krishnamoorthy , Amit Ohri , Ruchi Mathur , Kapil Juneja , Karishma Prithviraj Pamnani , Yudhit Mehta
IPC: G06Q30/02 , G06N3/123 , G06Q30/0202
CPC classification number: G06N3/123 , G06Q30/0202
Abstract: Aspects of the disclosure relate to using synthetic DNA stranding and mutant nucleotide processes to conduct enterprise market volatility predictions. In some embodiments, a computing platform may receive raw market data from a plurality of lines of business of an enterprise organization. Thereafter, the computing platform may preprocess the raw market data to obtain enterprise level market data, execute synthetic DNA stranding of the enterprise level market data to obtain synthetic DNA stranded market data, run the synthetic DNA stranded market data through one or more market volatility models, and compile results from the market volatility models on the synthetic DNA stranded market data. The computing platform may transmit results from the market volatility models on the synthetic DNA stranded market data. The transmitted results may be configured to display a market application interface that includes market volatility forecasting parameters based on results of the market volatility models.
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公开(公告)号:US11823064B2
公开(公告)日:2023-11-21
申请号:US17334086
申请日:2021-05-28
Applicant: Bank of America Corporation
Inventor: Manmohan Singh , Shantanu Singh , Vineet Kumar Upadhyay , Madhusudhanan Krishnamoorthy , Amit Ohri , Ruchi Mathur , Kapil Juneja , Karishma Prithviraj Pamnani , Yudhit Mehta
IPC: G06Q30/02 , G06N3/123 , G06Q30/0202
CPC classification number: G06N3/123 , G06Q30/0202
Abstract: Aspects of the disclosure relate to using synthetic DNA stranding and mutant nucleotide processes to conduct enterprise market volatility predictions. In some embodiments, a computing platform may initiate a set of instructions associated with performing an action on a synthetic DNA market data set associated with a plurality of lines of business across an enterprise organization. Thereafter, the computing platform may convert the set of instructions to a mutant nucleotide sequence, and insert the mutant nucleotide sequence into the synthetic DNA market data set. The computing platform may extract, using the mutant nucleotide sequence, target information from the synthetic DNA market data set, and validate the target information to detect one or more anomalies. The computing platform may remove the one or more data anomalies, and subsequently output a validated synthetic DNA market data set to a synthetic DNA client server.
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公开(公告)号:US11704575B2
公开(公告)日:2023-07-18
申请号:US16230928
申请日:2018-12-21
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor: Karin Strauss , Luis Ceze , Johannes Staffan Anders Linder
Abstract: Neural networks can be implemented with DNA strand displacement (DSD) circuits. The neural networks are designed and trained in silico taking into account the behavior of DSD circuits. Oligonucleotides comprising DSD circuits are synthesized and combined to form a neural network. In an implementation, the neural network may be a binary neural network in which the output from each neuron is a binary value and the weight of each neuron either maintains the incoming binary value or flips the binary value. Inputs to the neural network are one more oligonucleotides such as synthetic oligonucleotides containing digital data or natural oligonucleotides such as mRNA. Outputs from the neural networks may be oligonucleotides that are read by directly sequencing or oligonucleotides that generate signals such as by release of fluorescent reporters.
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9.
公开(公告)号:US20190251268A1
公开(公告)日:2019-08-15
申请号:US15905121
申请日:2018-02-26
Inventor: Sukhwan Lee , Eungju Lee , Dong Yeop Lee , Ju Hyeon Jeong
Abstract: Disclosed is a reversible DNA information hiding method based on prediction-error expansion and histogram shifting, the method being capable of false start codon prevention, original sequence length preservation, high watermark capacity, and blind detection based on prediction-error expansion and histogram shifting without biological mutation.
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公开(公告)号:US20190080760A1
公开(公告)日:2019-03-14
申请号:US15690189
申请日:2017-08-29
Applicant: Dodo OmniData, Inc.
Inventor: Paul F. Predki , Maja Cassidy
IPC: G11C13/02 , G06N3/12 , G06F19/22 , C12Q1/6869
CPC classification number: G11C13/02 , B82Y10/00 , C12Q1/68 , C12Q1/6869 , G06N3/123 , G16B30/00 , C12Q2563/116 , C12Q2565/631 , C12Q2521/131
Abstract: The disclosure provides a novel system of storing information using a charged polymer, e.g., DNA, the monomers of which correspond to a machine-readable code, e.g., a binary code, and which can be synthesized and/or read using a novel nanochip device comprising nanopores; novel methods and devices for synthesizing oligonucleotides in a nanochip format; novel methods for synthesizing DNA in the 3′ to 5′ direction using topoisomerase; novel methods and devices for reading the sequence of a charged polymer, e.g., DNA, by measuring capacitive variance as the polymer passes through the nanopore; and further provides compounds, compositions, methods and devices useful therein.
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