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    Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
    1.
    发明授权
    Process for the production of R(-)-4-halo-3-hydroxybutyronitrile 失效
    制备R（ - ） - 4-卤代-3-羟基丁腈的方法

    公开(公告)号：US5210031A

    公开(公告)日：1993-05-11

    申请号：US830516

    申请日：1992-02-03

    申请人： Tetsuji Nakamura ,  Fujio Yu

    发明人： Tetsuji Nakamura ,  Fujio Yu

    IPC分类号： C12P13/00

    CPC分类号： C12P13/002 ,  Y10S435/822 ,  Y10S435/843 ,  Y10S435/844 ,  Y10S435/845 ,  Y10S435/846

    摘要： A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting an epihalohydrin with a halohydrin-halide-lyase originating from a microorganism selected from the group consisting of: Corynebacterium sp. N-2354 FERM BP-2726 and Microbacterium sp. N-4701 FERM BP-2644 in the presence of an alkali cyanide to thereby convert the epihalohydrin into the 4-halo-3-hydroxybutyronitrile and collecting the product thus formed is disclosed. According to this process, a 4-halo-3-hydroxybutyronitrile which is highly useful in the syntheses of various medicines and physiologically active substances can be easily and efficiently produced from an inexpensive starting material.

    摘要翻译： 一种制备4-卤代-3-羟基丁腈的方法，其包括使表卤代醇与源自选自以下的微生物的卤代醇 - 卤化物裂解酶反应：棒状杆菌属 N-2354 FERM BP-2726和Microbacterium sp。 N-4701 FERM BP-2644在碱金属氰化物的存在下，从而将表卤代醇转化成4-卤代-3-羟基丁腈并收集如此形成的产品。 根据该方法，可以从廉价的原料容易且有效地制备在各种药物和生理活性物质的合成中非常有用的4-卤代-3-羟基丁腈。