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公开(公告)号：US5792626A
公开(公告)日：1998-08-11
申请号：US716588
申请日：1996-09-18
IPC分类号： G01N33/53 , A61K38/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K14/555 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , C07K1/00 , A01K37/18 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4718 , A61K38/00
摘要： The present invention provides a novel human interferon-inducible protein (HIFI) and the polynucleotides which identify and encode HIFI. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HIFI and for a method for producing the protein. The invention also provides compositions containing HIFI.
摘要翻译： 本发明提供新型人干扰素诱导蛋白（HIFI）和识别和编码HIFI的多核苷酸。 本发明提供了包含编码HIFI的核酸序列和用于产生蛋白质的方法的遗传工程表达载体和宿主细胞。 本发明还提供含有HIFI的组合物。
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公开(公告)号：US07425605B2
公开(公告)日：2008-09-16
申请号：US10183019
申请日：2002-06-26
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/28 , C07K2319/30 , C12N9/90 , C12N2799/026 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/10 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07838008B2
公开(公告)日：2010-11-23
申请号：US10929040
申请日：2004-08-27
申请人： Mitchell F. Brin , Stephen Donovan
发明人： Mitchell F. Brin , Stephen Donovan
CPC分类号： A61K38/4893 , A61K38/00 , Y02A50/469
摘要： Methods for treating diverse cancers by local administration of a botulinum toxin to or to the vicinity of the cancer.
摘要翻译： 通过局部施用肉毒杆菌毒素至癌症附近或其附近来治疗多种癌症的方法。
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公开(公告)号：US07087575B2
公开(公告)日：2006-08-08
申请号：US10198697
申请日：2002-07-18
申请人： Elliott Richelson , Paul Fredrickson , Mona Boules
发明人： Elliott Richelson , Paul Fredrickson , Mona Boules
CPC分类号： A61K38/10 , A61K31/137 , Y10S514/813 , A61K2300/00
摘要： The invention provides methods and materials for treating the effects of nicotine. In particular, the invention provides methods that involve administering a neurotensin receptor (NTR) agonist to a mammal that has been exposed to nicotine. The NTR agonist typically is administered in an amount effective to diminish or abolish the effects that nicotine has on the treated mammal. NTR agonists that can be used in methods of the invention include neurotensin (NT) polypeptide analogs such as NT69L. The invention also provides compositions containing an NTR agonist in combination with other agents used to help overcome nicotine effects such as sensitization and dependence. The compositions provided herein can be used to treat the effects of nicotine, including hyperactivity, hypothermia, respiratory distress, and hypertension.
摘要翻译： 本发明提供了治疗尼古丁作用的方法和材料。 特别地，本发明提供了涉及向暴露于尼古丁的哺乳动物施用神经降压素受体（NTR）激动剂的方法。 NTR激动剂通常以有效减少或消除尼古丁对治疗的哺乳动物的作用的量施用。 可用于本发明方法的NTR激动剂包括神经丝氨酸（NT）多肽类似物，如NT69L。 本发明还提供含有NTR激动剂与用于帮助克服尼古丁效应如致敏和依赖性的其它试剂组合的组合物。 本文提供的组合物可用于治疗尼古丁的作用，包括多动症，低体温，呼吸窘迫和高血压。
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公开(公告)号：US07846456B2
公开(公告)日：2010-12-07
申请号：US11192777
申请日：2005-07-29
申请人： Mitchell F. Brin , Stephen Donovan
发明人： Mitchell F. Brin , Stephen Donovan
CPC分类号： A61K38/4893 , A61K38/00
摘要： A method for treating a mammary gland disorder, including hyperplastic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue.
摘要翻译： 一种通过将肉毒杆菌毒素局部施用于受影响的乳腺组织或其附近来治疗乳腺疾病的方法，包括增生性，高渗性，囊性和/或肿瘤性乳腺组织。
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公开(公告)号：US07838007B2
公开(公告)日：2010-11-23
申请号：US10071826
申请日：2002-02-08
申请人： Mitchell F. Brin , Stephen Donovan
发明人： Mitchell F. Brin , Stephen Donovan
CPC分类号： A61K38/4893 , A61K38/00
摘要： A method for treating a mammary gland disorder, including hyperplastic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue.
摘要翻译： 一种通过将肉毒杆菌毒素局部施用于受影响的乳腺组织或其附近来治疗乳腺疾病的方法，包括增生性，高渗性，囊性和/或肿瘤性乳腺组织。
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