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    Dinucleotides useful for the treatment of lung disease
    3.
    发明申请
    Dinucleotides useful for the treatment of lung disease 审中-公开
    用于治疗肺部疾病的二核苷酸

    公开(公告)号：US20010041682A1

    公开(公告)日：2001-11-15

    申请号：US09850609

    申请日：2001-05-07

    发明人： Monroe Jackson Stutts III ,  Richard C. Boucher JR. ,  Eduardo R. Lazarowski ,  Cara A. Geary

    IPC分类号： A61K031/7076 ,  A61K031/7068

    CPC分类号： C07H21/00 ,  A61K9/0073 ,  A61K31/70 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7084 ,  Y10S514/851 ,  A61K31/495 ,  A61K2300/00

    摘要： A pharmaceutical formulation comprises, in an amount effective to hydrate lung mucous secretions, a compound of Formula (I): 1 wherein n is from 1 to 6; X is nullOH or nullSH; A and B are each independently selected from the group consisting of: 2 nullwherein R is H or Br; or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A method of hydrating mucous secretions in the lungs of a subject in need of such treatment, comprising administering to the lungs of the subject a compound of Formula I as given above, is also disclosed.

    摘要翻译： 药物制剂包含以有效水合肺粘液分泌的量的式（I）化合物：其中n为1至6; X是-OH或-SH; A和B各自独立地选自：其中R是H或Br; 或其药学上可接受的盐在药学上可接受的载体中。 本发明还公开了一种对需要这种治疗的受试者的肺中的粘液分泌物进行水合的方法，其中还包括对受试者的肺给予上文给出的式I化合物。

    Medicinal composition for diabetic neuropathy
    4.
    发明申请
    Medicinal composition for diabetic neuropathy 失效
    糖尿病性神经病变药物组成

    公开(公告)号：US20040014711A1

    公开(公告)日：2004-01-22

    申请号：US10381716

    申请日：2003-03-28

    发明人： Kazuki Endo ,  Toichi Abiru ,  Junzo Kamei

    IPC分类号： A61K031/7068

    CPC分类号： C07H19/10 ,  A61K31/7068

    摘要： The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5null-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present invention is effective for neuropathy mainly caused by metabolic disturbance of carbohydrate and is also superior in safety. Neuropathy includes peripheral neuropathy and dysautonomia. CDP-choline is effective even by oral administration.

    摘要翻译： 本发明涉及含有胞苷5'-二磷酸胆碱（CDP-胆碱）作为活性成分的预防或治疗糖尿病性神经病的药剂。 用于预防或治疗本发明的糖尿病性神经病的药剂对于主要由碳水化合物的代谢紊乱引起的神经病有效，并且安全性也优异。 神经病包括周围神经病和自主神经病。 CDP-胆碱甚至通过口服给药也是有效的。

    3'-prodrugs of 2'-deoxy-beta-L-nucleosides
    5.
    发明申请
    3'-prodrugs of 2'-deoxy-beta-L-nucleosides 有权
    2'-脱氧-β-L-核苷的3'-前药

    公开(公告)号：US20030083306A1

    公开(公告)日：2003-05-01

    申请号：US09883033

    申请日：2001-06-15

    发明人： Jean-Louis Imbach ,  Martin L. Bryant ,  Gilles Gosselin

    IPC分类号： A61K031/7076 ,  A61K031/7068 ,  C07H019/16 ,  C07H019/06

    CPC分类号： C07H19/16 ,  C07H19/06

    摘要： The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compound and compositions of 3null-esters of 2null-deoxy-null-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents. Compound and compositions of 3null,5null-diesters of 2null-deoxy-null-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents, are also disclosed.

    摘要翻译： 本发明涉及用于治疗感染乙型肝炎病毒的宿主的化合物，组合物和方法。 具体地，公开了2'-脱氧-β-L-核苷的3'-酯的化合物和组合物，其可以单独施用或与其它抗乙型肝炎药物组合施用。 公开了可以单独施用或与其它抗乙型肝炎试剂组合施用的2'-脱氧-β-L-核苷的3'，5'-二酯的化合物和组合物。

    Nucleotide compounds that block the bitter taste of oral compositions
    6.
    发明申请
    Nucleotide compounds that block the bitter taste of oral compositions 失效
    阻断口服组合物苦味的核苷酸化合物

    公开(公告)号：US20020177576A1

    公开(公告)日：2002-11-28

    申请号：US09865346

    申请日：2001-05-25

    发明人： Richard Alexander McGregor ,  Stephen Anthony Gravina

    IPC分类号： A61K031/7068 ,  A61K031/7076

    CPC分类号： A61K47/24 ,  A23L27/23 ,  A61K9/0056 ,  A61K9/0095

    摘要： Nucleotides that block the bitter taste of foods, beverages, pharmaceutically active oral dose preparations, cosmetics and other bitter compounds that come into contact with taste tissue. The nucleotides consist of a purine or pyrimidine group, or derivative thereof, and an ionizable phosphate or other anionic organic molecule.

    摘要翻译： 妨碍与味觉组织接触的食品，饮料，药物活性口服剂量制剂，化妆品和其他苦味化合物的苦味的核苷酸。 核苷酸由嘌呤或嘧啶基团或其衍生物和可电离的磷酸盐或其它阴离子有机分子组成。

    3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatites virus infections
    7.
    发明申请
    3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatites virus infections 失效
    3'-或2'-羟甲基取代的核苷衍生物用于治疗肝炎病毒感染

    公开(公告)号：US20020055483A1

    公开(公告)日：2002-05-09

    申请号：US09834596

    申请日：2001-04-13

    发明人： Kyoichi A. Watanabe ,  S. Balakrishna Pai

    IPC分类号： A61K031/7076 ,  A61K031/7068 ,  A61K031/675 ,  A61K031/522 ,  A61K031/513

    CPC分类号： C07H19/10 ,  C07H19/06 ,  C07H19/16 ,  C07H19/20

    摘要： The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a proliferative disorder in a patient using an effective amount of a compound selected from the group consisting of formulas nullInull- nullIVnull below and mixtures of two or more thereof: 1 wherein the substituents are as defined herein. Pharmaceutical compositions comprising these compounds in combination with other HBV, HCV, or HDV agents is also disclosed.

    摘要翻译： 本发明涉及使用有效量的化合物治疗患者的乙型肝炎病毒（HBV）感染，丙型肝炎病毒（HCV）感染，丙型肝炎病毒（HDV）感染或增殖性疾病的组合物和方法 选自下述式[I] - [IV]及其两种或更多种的混合物：其中取代基如本文所定义。 还公开了包含这些化合物与其它HBV，HCV或HDV药剂组合的药物组合物。

    Phosphoramidates and methods therefor
    8.
    发明申请
    Phosphoramidates and methods therefor 失效
    磷酰胺化物及其方法

    公开(公告)号：US20020004594A1

    公开(公告)日：2002-01-10

    申请号：US09822376

    申请日：2001-03-30

    发明人： Richard F. Borch ,  Hugo Garrido-Hernandez ,  Sandra C. Tobias

    IPC分类号： C07H019/04 ,  A61K031/7068 ,  A61K031/665 ,  A61K031/67 ,  A61K031/664

    CPC分类号： C07H19/10 ,  C07F9/2458 ,  C07F9/26 ,  C07F9/65515 ,  C07F9/655345

    摘要： Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.

    摘要翻译： 描述了羟基官能或氨基官能化合物的新型氨基磷酸衍生物，包括氨基酸，肽，肽模拟物和核苷酸类似物。 这些化合物能够增强药物的细胞内递送作为其相应的磷酸酯或酰胺。 描述的氨基磷酸酯化合物表现出抗增殖活性。 提供药物制剂用于治疗癌症。

    Methods for inhibiting angiogenesis
    9.
    发明申请
    Methods for inhibiting angiogenesis 失效
    抑制血管发生的方法

    公开(公告)号：US20020160979A1

    公开(公告)日：2002-10-31

    申请号：US09779447

    申请日：2001-02-09

    发明人： Dipak K. Banerjee ,  Juan A. Martinez

    IPC分类号： A61K031/7068

    CPC分类号： A61K31/7068

    摘要： A method for inhibiting angiogenesis, including: administering a nucleoside, such as tunicamycin, in an amount effective to inhibit angiogenesis, to a patient in need of such treatment. A method for inhibiting angiogenesis, including: administering a nucleoside, which comprises glucosamine, in an amount effective to inhibit angiogenesis, to a patient in need of such treatment; wherein the nucleoside is administered for a period of time, subsequently the administration of the nucleoside is suspended for a period of time of at least about 1 week, and subsequently the administration of the nucleoside is resumed.

    摘要翻译： 一种抑制血管发生的方法，包括：向有需要这种治疗的患者施用有效抑制血管生成的核苷，如衣霉素。 一种抑制血管发生的方法，包括：向需要这种治疗的患者施用含有有效抑制血管生成的量的包含葡糖胺的核苷; 其中所述核苷被施用一段时间，随后将所述核苷的施用悬浮至少约1周的时间，随后再次给予所述核苷。