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公开(公告)号:US06830749B2
公开(公告)日:2004-12-14
申请号:US10180895
申请日:2002-06-25
申请人: Wei-Wei Zhang , Jack A. Roth
发明人: Wei-Wei Zhang , Jack A. Roth
IPC分类号: A61K4300
CPC分类号: C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/4746 , C12N7/00 , C12N2710/10343 , A61K2300/00
摘要: Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p53 adenovirus constructs, including methods for restoring p53 function and tumor suppression in cells and animals having abnormal p53.
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2.
公开(公告)号:US06174513B1
公开(公告)日:2001-01-16
申请号:US09126545
申请日:1998-07-30
IPC分类号: A61K4300
CPC分类号: A61K51/08 , A61K51/083 , A61K51/088 , Y10S436/804 , Y10S514/975
摘要: Surfactants alone or in combination with salts are used to stabilize radiolabeled peptides and proteins contained in diagnostic or therapeutic radiopharmaceutical compositions.
摘要翻译: 单独或与盐组合使用的表面活性剂用于稳定诊断或治疗放射性药物组合物中所含的放射性标记肽和蛋白质。
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