公开(公告)号：US20180353626A1

公开(公告)日：2018-12-13

申请号：US16101544

申请日：2018-08-13

申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Katsunori TERANISHI ,  Hitoshi HIRATA ,  Tetsuya ARAI

IPC分类号： A61K49/00 ,  A61B5/0205 ,  A61B5/20 ,  C09B23/08 ,  C09B23/01 ,  C08B37/16 ,  A61M5/00 ,  C09B67/00 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0275

CPC分类号： A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

公开(公告)号：US20170258939A1

公开(公告)日：2017-09-14

申请号：US15422961

申请日：2017-02-02

申请人： Medical Technology Transfer Holding B.V.

发明人： Gerrit Reinold Jacob Melles

IPC分类号： A61K49/00 ,  A61K9/00

CPC分类号： A61K49/001 ,  A61K9/0048 ,  A61K49/0023 ,  A61K49/0028 ,  A61K49/003 ,  A61K49/0034 ,  A61K49/006 ,  A61K49/0071

摘要： The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

公开(公告)号：US20170157273A1

公开(公告)日：2017-06-08

申请号：US15438047

申请日：2017-02-21

申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Katsunori TERANISHI ,  Hitoshi HIRATA ,  Tetsuya ARAI

IPC分类号： A61K49/00 ,  C08B37/16

CPC分类号： A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

公开(公告)号：US09309292B2

公开(公告)日：2016-04-12

申请号：US14041184

申请日：2013-09-30

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K39/00 ,  C07K14/22 ,  A61K9/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/14 ,  A61K49/22 ,  B82Y5/00 ,  C07K7/06 ,  C12N15/62 ,  A61K38/16 ,  A61K45/06 ,  C07K14/47 ,  G01N33/50 ,  A61K38/00

CPC分类号： C07K14/22 ,  A61K9/0085 ,  A61K38/00 ,  A61K38/164 ,  A61K45/06 ,  A61K47/64 ,  A61K47/66 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0041 ,  A61K49/0056 ,  A61K49/04 ,  A61K49/085 ,  A61K49/14 ,  A61K49/221 ,  B82Y5/00 ,  C07K7/06 ,  C07K14/47 ,  C12N15/625 ,  G01N33/5091

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

摘要翻译： 本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

公开(公告)号：US20160011199A1

公开(公告)日：2016-01-14

申请号：US14715799

申请日：2015-05-19

申请人： Purdue Research Foundation

发明人： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low

IPC分类号： G01N33/574 ,  G01N33/58 ,  A61K49/00 ,  C07D475/04

CPC分类号： A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

摘要翻译： 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了制备和使用化合物的方法和组合物，并入化合物的方法，以及并入化合物的试剂盒。

公开(公告)号：US09061057B2

公开(公告)日：2015-06-23

申请号：US14207130

申请日：2014-03-12

申请人： Purdue Research Foundation

发明人： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50

CPC分类号： A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

摘要翻译： 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了制备和使用化合物的方法和组合物，并入化合物的方法，以及并入化合物的试剂盒。

公开(公告)号：US20150152267A1

公开(公告)日：2015-06-04

申请号：US14616117

申请日：2015-02-06

申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

发明人： Katsunori TERANISHI ,  Hitoshi Hirata ,  Tetsuya Arai

IPC分类号： C09B67/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/20 ,  A61B5/026 ,  A61K49/00 ,  A61M5/00

CPC分类号： A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

摘要翻译： 本发明的目的在于提供一种新的吲哚菁化合物，其解决了常规使用的吲哚菁绿的问题，例如在水或生理盐水中的溶解度，其合成方法和纯化方法，以及包含新的吲哚菁化合物的诊断组合物。 此外，提供了用于评估新型吲哚菁化合物的生物动力学的方法和用于测量生物动力学的装置，以及利用诊断组合物来观察生物体中的血液等流体的循环的方法和装置。 此外，发现了一种新颖的吲哚菁化合物，其中近红外荧光靛蓝分子中的疏水部分包含在环状糖链环糊精的空腔中，以用葡萄糖覆盖靛蓝分子中的疏水部分，以及合成方法和 其纯化方法。 此外，发现了通过静脉内给药对肝脏以外的器官进行荧光成像的方法，评价新型吲哚菁化合物的生物动力学的评价方法，生物动力学测定装置以及用于使流体（例如血液）的循环可视化的方法和装置 在生物体中，利用包含新的吲哚菁化合物的诊断组合物。

公开(公告)号：US20140271484A1

公开(公告)日：2014-09-18

申请号：US14135099

申请日：2013-12-19

申请人： Purdue Research Foundation

发明人： Philip S. Low ,  Sumith A. Kularatne ,  Lindsay E. Kelderhouse

IPC分类号： A61K49/00

CPC分类号： A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods of imaging of inflammatory diseases using the compounds.

摘要翻译： 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了使用该化合物成像炎性疾病的方法。

公开(公告)号：US20140056820A1

公开(公告)日：2014-02-27

申请号：US14041184

申请日：2013-09-30

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M Fialho

IPC分类号： C07K14/22 ,  A61K38/16 ,  G01N33/50 ,  A61K49/04 ,  A61K49/14 ,  A61K49/22 ,  C07K14/47 ,  A61K45/06

CPC分类号： C07K14/22 ,  A61K9/0085 ,  A61K38/00 ,  A61K38/164 ,  A61K45/06 ,  A61K47/64 ,  A61K47/66 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0041 ,  A61K49/0056 ,  A61K49/04 ,  A61K49/085 ,  A61K49/14 ,  A61K49/221 ,  B82Y5/00 ,  C07K7/06 ,  C07K14/47 ,  C12N15/625 ,  G01N33/5091

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

摘要翻译： 本发明公开了用于将货物化合物递送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

公开(公告)号：US08563043B2

公开(公告)日：2013-10-22

申请号：US13142730

申请日：2010-03-16

申请人： Zdravka Medarova ,  Anna Moore ,  Mehmet Yigit

发明人： Zdravka Medarova ,  Anna Moore ,  Mehmet Yigit

IPC分类号： A61K9/14

CPC分类号： A61K49/1833 ,  A61K41/0052 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0423 ,  A61K49/183 ,  A61K49/1863 ,  B82Y5/00

摘要： A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses.

摘要翻译： 公开了一种镀金氧化铁纳米颗粒，其制备方法及其使用方法。 纳米颗粒基本上不含毒素（使其临床适用），易于功能化，并且可用作许多成像技术的造影剂，包括以至少两种不同成像模式对受试者进行成像。 此外，纳米颗粒非常适合于治疗用途。