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公开(公告)号：US08697137B2
公开(公告)日：2014-04-15
申请号：US10220982
申请日：2001-03-23
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61K9/50
CPC分类号： A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20120309644A1
公开(公告)日：2012-12-06
申请号：US13552356
申请日：2012-07-18
申请人： Lee O. Lomas , Jian Ding , Egisto Boschetti
发明人： Lee O. Lomas , Jian Ding , Egisto Boschetti
IPC分类号： C40B30/04 , G01N27/447 , B01D15/42 , F17D1/00
CPC分类号： G01N30/461 , B01D15/325 , B01D15/362 , B01D15/363 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/026 , B01L2200/028 , B01L2300/0681 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , C07K1/34 , G01N27/44704 , G01N27/44795 , G01N30/466 , G01N30/468 , Y10T137/2224 , Y10T137/794 , Y10T137/86187 , Y10T436/255
摘要： The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.
摘要翻译： 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。
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3.发明授权Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物公开(公告)号：US07326776B2
公开(公告)日：2008-02-05
申请号：US11531863
申请日：2006-09-14
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译： 对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。 合适的配体包括任选稠合的芳族基团，杂芳族基团或杂环基团，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。 这些树脂在其使用条件下具有阴离子特性。 生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。
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公开(公告)号：US20080023630A1
公开(公告)日：2008-01-31
申请号：US11557286
申请日：2006-11-07
申请人： Egisto Boschetti , Lee O. Lomas
发明人： Egisto Boschetti , Lee O. Lomas
IPC分类号： H01J49/00
CPC分类号： H01J49/0418
摘要： A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.
摘要翻译： 质谱仪探针由掺杂有导电材料的非导电聚合物形成。 探针可以用作平行激光离子解吸/电离飞行时间质谱仪中的或作为排斥板的一部分。 在探针之前或期间，探针上的透明位置使其上放置的样品可视化。 探头的导电性质保持了施加到样品的电磁场的一致性。 该探头还显示出低的除气和高的机械和化学稳定性，从而使其能够重复使用。
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公开(公告)号：US20070254378A1
公开(公告)日：2007-11-01
申请号：US11682655
申请日：2007-03-06
申请人： Hongmin Zhang , Egisto Boschetti , Lee Lomas , Pil-Je Um
发明人： Hongmin Zhang , Egisto Boschetti , Lee Lomas , Pil-Je Um
CPC分类号： C08F220/36 , B01D71/28 , C02F1/683 , C02F2101/20 , C08F220/30 , C08F222/1006 , Y10T436/24
摘要： This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.
摘要翻译： 本发明提供了包含芳基的螯合部分。 包含螯合部分的单体可以聚合成螯合聚合物。 螯合聚合物可用于螯合金属。 金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。 螯合聚合物可以包括在诸如芯片和色谱材料的制品中。
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6.发明授权Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物公开(公告)号：US07144743B2
公开(公告)日：2006-12-05
申请号：US10660738
申请日：2003-09-12
申请人： Egisto Boschetti , Pierre Girot
发明人： Egisto Boschetti , Pierre Girot
IPC分类号： G01N33/544 , G01N33/548 , G01N33/545 , G01N30/02 , C07K1/04 , C07K1/14 , C07D277/62 , C07K1/16
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译： 对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。 合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。 这些树脂在其使用条件下具有阴离子特性。 生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。
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公开(公告)号：US20060063732A1
公开(公告)日：2006-03-23
申请号：US11253435
申请日：2005-10-18
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
CPC分类号： A61K9/0019 , A61K9/1635 , A61K48/00 , A61K48/0008 , A61K48/0041
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地递送与用于栓塞基因治疗的转染剂物理连接的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于使用可注射组合物治疗血管生成和非血管生成依赖性疾病的方法。
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8.发明申请Small dense microporous solid support materials, their preparation, and use for purification for large macromolecules and bioparticles 审中-公开小型微孔固体支持材料，它们的制备和用于大分子和生物颗粒的纯化公开(公告)号：US20050269257A1
公开(公告)日：2005-12-08
申请号：US11185963
申请日：2005-07-21
申请人： Nicolas Voute , Egisto Boschetti , Pierre Girot
发明人： Nicolas Voute , Egisto Boschetti , Pierre Girot
IPC分类号： B01J20/281 , B01D15/02 , B01D15/08 , B01D15/18 , B01J20/02 , B01J20/06 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/32 , C04B38/00 , G01N30/88
CPC分类号： B01J20/3282 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
摘要： The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.
摘要翻译： 本发明提供小而致密的矿物氧化物固体支持物或微珠，其包含其中根据聚合物皮肤的致密微孔矿物氧化物基质，以及它们在下游加工中的用途，特别是用于生物颗粒或高分子量大分子的流化床净化。
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公开(公告)号：US06790456B2
公开(公告)日：2004-09-14
申请号：US10222819
申请日：2002-08-19
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61F1300
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
摘要翻译： 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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公开(公告)号：US5486293A
公开(公告)日：1996-01-23
申请号：US215201
申请日：1994-03-21
申请人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
发明人： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
CPC分类号： B01J20/3282 , B01D15/00 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28097
摘要： Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.
摘要翻译： 公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。 所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。 新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。
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