公开(公告)号：US06792315B2

公开(公告)日：2004-09-14

申请号：US10419627

申请日：2003-04-21

申请人： John Carter ,  Bradford Siff

发明人： John Carter ,  Bradford Siff

IPC分类号： A61N134

CPC分类号： A61N1/36021 ,  A61N1/326

摘要： An apparatus for providing therapeutic electric current to a treatment site of a patient is disclosed, which provides two oscillating or pulsing electric alternating currents, of frequencies which differ from each other by as little as 1 Hz and up to about 250 Hz, but each being of frequency at least about 1 KHz. The apparatus requires only one feed electrode adapted to feed the electric currents to selected feed sites on or beneath the epidermal or mucous surface of the patient, and only one return electrode adapted to be positioned on or beneath the epidermal or mucous surface of the patient, locally to the treatment site. The apparatus includes a feedback subsystem to detect impedance changes in the patient and accordingly adjust the output of the apparatus.

摘要翻译： 公开了一种用于向患者的治疗部位提供治疗电流的装置，其提供频率彼此不超过1Hz和高达约250Hz的两个振荡或脉冲电动交流电流，但是每个 的频率至少约1KHz。 该装置仅需要一个馈电电极，其适于将电流馈送到患者的表皮或粘膜表面上或下面的选定进食部位，并且仅一个返回电极适于定位在患者的表皮或粘膜表面上或下方， 在当地到治疗现场。 该装置包括用于检测患者中的阻抗变化的反馈子系统，并因此调整装置的输出。

公开(公告)号：US06609031B1

公开(公告)日：2003-08-19

申请号：US08659919

申请日：1996-06-07

申请人： Jay Law ,  William Borkan ,  Lance Ehren ,  George Van Campen ,  John Erickson

发明人： Jay Law ,  William Borkan ,  Lance Ehren ,  George Van Campen ,  John Erickson

IPC分类号： A61N134

CPC分类号： A61N1/36021 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/37229

摘要： An electronic stimulation system is used to control pain over multiple regions of a patient's body. The system has one or more percutaneous leads, each having multiple electrodes, implanted within the patient's epidural space parallel to the axis of the spinal cord. The leads are connected to either a totally implanted system or a radio frequency system. The system is able to treat pain over different regions of a patient's body by “simultaneously” stimulating the patient with at least three different stimulation settings. “Simultaneous” stimulation involves sequentially stimulating the patient with the multiple stimulation settings such that the patient receives the cumulative effect of each stimulation setting, while not perceiving the transition from one stimulation setting to another.

摘要翻译： 电子刺激系统用于控制患者身体的多个区域的疼痛。 系统具有一个或多个经皮引线，每个具有多个电极，植入患者硬脊膜空间内平行于脊髓的轴线。 引线连接到完全植入系统或射频系统。 该系统能够通过“同时”刺激患者至少三种不同的刺激设置来治疗患者身体的不同区域的疼痛。 “同时”刺激涉及以多次刺激设置顺序地刺激患者，使得患者接收每个刺激设置的累积效应，而不感知从一个刺激设置到另一个刺激设置的过渡。

公开(公告)号：US06535767B1

公开(公告)日：2003-03-18

申请号：US09935007

申请日：2001-08-21

申请人： James W. Kronberg

发明人： James W. Kronberg

IPC分类号： A61N134

CPC分类号： A61N1/36021 ,  A61N1/326 ,  A61N1/36071 ,  A61N1/36178

摘要： An apparatus for generating an electrical signal for use in biomedical applications, including two timing blocks for generating timing intervals T1-T7, an interconnection block for combining these intervals into an output signal having predetermined relationships among the intervals, an output block for transmitting the output signal to a load, and, optionally, a filter for removing unwanted frequency components from the output signal and an adjustment block for selecting from among a plurality of output signals with predetermined characteristics. The output is a repeating succession of a burst of rectangular waves, an equalizing pulse (if needed) to cancel net DC, and a rest period of no signal.

摘要翻译： 一种用于生成用于生物医学应用的电信号的装置，包括用于产生定时间隔T1-T7的两个定时块，用于将这些间隔组合为具有间隔之间的预定关系的输出信号的互连块，用于发送输出的输出块 信号到负载，以及可选地用于从输出信号中去除不需要的频率分量的滤波器和用于从具有预定特性的多个输出信号中进行选择的调整块。 输出是矩阵波的重复序列，消除净DC的均衡脉冲（如果需要）和无信号的休止周期。

公开(公告)号：US06314325B1

公开(公告)日：2001-11-06

申请号：US09336241

申请日：1999-06-18

申请人： William R. Fitz

发明人： William R. Fitz

IPC分类号： A61N134

CPC分类号： A61N1/36071 ,  A61N1/08

摘要： Methods and apparatus are disclosed for hyperpolarizing the medial branch of the spinal nerve associated with a painful spinal facet joint so as to block pain impulses from reaching the spinal cord. The preferred apparatus includes a neurostimulator and two or more electrodes which carry electrical pulses to the target nerve or nerves. The impulses are intense enough to cause hyperpolarization of a given medial branch and its articular branches, but not so large as to spread to the spinal cord itself. In the preferred embodiment the stimulator is physically small and battery operated, facilitating implantation underneath the skin. The stimulator includes a controller and appropriate electronics operative to generate electrical impulses tailored to an individual's need for appropriate pain relief in terms of pulse frequency, pulse width, and pulse amplitude. In an alternative embodiment, the stimulator further includes electrodes and electrical circuitry operative to monitor myoelectrical activity generated by the surrounding muscles and modulate the impulses generated by the stimulator to meet the demands of the individual's activity and/or prolong battery life.

摘要翻译： 公开了用于超极化与疼痛脊柱小关节相关的脊髓神经的内侧分支的方法和装置，以阻止疼痛脉冲到达脊髓。 优选的装置包括神经刺激器和将电脉冲携带到目标神经或神经的两个或更多个电极。 脉冲强度足以导致给定的中间分支及其关节分支的超极化，但不会扩大到脊髓本身。 在优选实施例中，刺激器物理上小且电池操作，便于在皮肤下植入。 刺激器包括控制器和适当的电子装置，用于产生电脉冲，其根据脉冲频率，脉冲宽度和脉冲幅度针对个体需要适当的疼痛缓解。 在替代实施例中，刺激器还包括电极和电路，其可操作以监视由周围肌肉产生的肌电活动并且调节由刺激器产生的脉冲以满足个体活动的需求和/或延长电池寿命。

公开(公告)号：US06836685B1

公开(公告)日：2004-12-28

申请号：US10018615

申请日：2002-03-11

申请人： William R. Fitz

发明人： William R. Fitz

IPC分类号： A61N134

CPC分类号： A61N1/08 ,  A61N1/36071

摘要： Methods, and apparatus are disclosed for stimulation the central, peripheral, and autonomic with particular attention being given to the medial branch (210) of the spinal nerve (212) associated with a painful spinal facet joint so as to block pain impulses from reaching the spinal cord. The preferred apparatus includes a neurostimulator (204), and two or more electrodes (206) which carry electrical pulses to the target nerves. The impulses are intense enough to cause stimulation of a given medial branch (210), and its articular branches, but not so large as to spread to the spinal cord itself. In the preferred embodiment the stimulator (204) is physically small and battery operated facilitating implantation underneath the skin. The stimulator (204) includes a controller (not shown), and appropriate electronics operative to generate electrical impulses tailored to an individual's need for appropriate pain relief in terms of pulse frequency, pulse width, and pulse amplitude. In an alternative embodiment, the stimulator (204) further includes electrodes (206), and electrical circuitry operative to monitor myoelectrical activity generated by the surrounding muscles, and modulate the impulses generated by the stimulator to meet the demands of the individual's activity and/or prolong battery life.

摘要翻译： 公开了用于刺激中枢，外周和自主神经的方法和装置，特别注意与疼痛脊柱小关节相关联的脊神经（212）的中间分支（210），以阻止疼痛脉冲到达 脊髓。 优选的装置包括神经刺激器（204）和携带电脉冲到目标神经的两个或更多个电极（206）。 脉冲强度足以刺激给定的中间分支（210）及其关节分支，但不会扩大到脊髓本身。 在优选实施例中，刺激器（204）在物理上很小并且电池操作便于植入在皮肤下方。 刺激器（204）包括控制器（未示出），并且适当的电子器件可操作地产生针对个体针对脉冲频率，脉冲宽度和脉冲幅度的适当疼痛缓解的需要而定制的电脉冲。 在替代实施例中，刺激器（204）还包括电极（206）和电路，其可操作以监视由周围肌肉产生的肌电活动，并且调节由刺激器产生的脉冲以满足个体的活动和/或 延长电池寿命。

公开(公告)号：US06711442B1

公开(公告)日：2004-03-23

申请号：US09288209

申请日：1999-04-08

申请人： Charles D. Swerdlow ,  Neal R. Swerdlow ,  James E. Brewer

发明人： Charles D. Swerdlow ,  Neal R. Swerdlow ,  James E. Brewer

IPC分类号： A61N134

CPC分类号： A61N1/395 ,  A61N1/36021 ,  A61N1/36071 ,  A61N1/39 ,  A61N1/3906 ,  A61N1/3956

摘要： A method and apparatus that pretreat a patient prior to each therapeutic painful stimulus in a series of therapeutic painful stimuli, comprising the application of pain inhibiting stimuli to the patient prior to the application of each therapeutic painful stimulus in the series. Applying pain inhibiting stimuli comprises the steps of sensing a need for a next therapeutic painful stimulus in a series, preparing to deliver the pain inhibiting stimuli to the patient prior to applying the next therapeutic painful stimulus, and delivering the pain inhibiting stimuli to the patient prior to applying the next therapeutic painful stimulus. The method and apparatus are embodied in modern, noninvasive, transcutaneous or transesophageal pacing devices, either as stand-alone cardiac pacemakers, combination pacemaker-ECG monitors, or combination pacemaker-monitor-defibrillators. The pain inhibiting prepulse method is intended primarily for use in conscious patients but may also be used in sleeping patients.

摘要翻译： 一种在一系列治疗性疼痛刺激中的每种治疗性疼痛刺激之前对患者进行预处理的方法和装置，包括在施用所述系列中的每种治疗性疼痛刺激之前向患者施加疼痛抑制性刺激。 应用疼痛抑制刺激包括以下步骤：感测需要下一次治疗性疼痛刺激的一系列，准备在施用下一个治疗性疼痛刺激之前将疼痛抑制刺激递送给患者，并将疼痛抑制刺激递送给患者 应用下一个治疗性的痛苦刺激。 该方法和装置体现在现代的，无创的，经皮的或经食道的起搏装置中，作为独立的心脏起搏器，组合的起搏器ECG监测器或组合的起搏器监测器 - 除颤器。 疼痛抑制前脉冲法主要用于有意识的患者，但也可用于睡眠患者。

公开(公告)号：US06584358B2

公开(公告)日：2003-06-24

申请号：US09756999

申请日：2001-01-08

申请人： John Carter ,  Bradford Siff

发明人： John Carter ,  Bradford Siff

IPC分类号： A61N134

CPC分类号： A61N1/36021 ,  A61N1/326

摘要： An electro-therapy apparatus and method for providing therapeutic electric current to a treatment site of a patient, having means for providing two oscillating or pulsing electric alternating currents, of frequencies which differ from each other by as little as 1 Hz and up to about 250 Hz, but each being of frequency at least about 1 KHz. The apparatus and method requires only one feed electrode adapted to feed the electric currents to selected feed sites on or beneath the epidermal or mucous surface of the patient, and only one return electrode adapted to be positioned on or beneath the epidermal or mucous surface of the patient, locally to the treatment site. The apparatus includes a feedback subsystem to detect impedance changes in the patient and accordingly adjust the output of the apparatus.

公开(公告)号：US06298265B1

公开(公告)日：2001-10-02

申请号：US09350831

申请日：1999-07-09

申请人： Paul A. Burgio

发明人： Paul A. Burgio

IPC分类号： A61N134

CPC分类号： A61N1/36021 ,  A01K1/0613 ,  A01K15/00 ,  A22B3/06

摘要： An article for use in applying an electrical stimulus to a pedicle area of an antlered animal includes a clamp for securely attaching the article to the pedicle area and an attached electrode for establishing electrical contact with the pedicle area. The article may be used in conjunction with a transcutaneous electrical nerve stimulation (TENS) system to anesthetize the pedicle area for harvesting purposes, or as part of a system to provide long or short term electrical stimulation to the pedicle in order to enhance blood flow to the area. Processes of applying electrical stimulation to the pedicle area to stimulate growth are also discussed.

摘要翻译： 用于将电刺激施加到鹿头动物的椎弓根区域的物品包括用于将物品牢固地附接到椎弓根区域的夹具和用于与椎弓根区域建立电接触的附接电极。 该物品可以与经皮电神经刺激（TENS）系统一起使用以麻醉用于收获目的的椎弓根区域，或者作为向椎弓根提供长期或短期电刺激的系统的一部分，以增强血流量 该地区。 还讨论了将电刺激应用于椎弓根区域以刺激生长的过程。

公开(公告)号：US06721603B2

公开(公告)日：2004-04-13

申请号：US10055021

申请日：2002-01-25

申请人： Jacob Zabara ,  Burke T. Barrett ,  Steven M. Parnis

发明人： Jacob Zabara ,  Burke T. Barrett ,  Steven M. Parnis

IPC分类号： A61N134

CPC分类号： A61N1/36071

摘要： A method and apparatus are disclosed for treating patients suffering from severe, unrelenting pain. A therapeutic stimulation signal is selectively applied from a stimulus generator, when activated, to at least some of plural electrodes implanted in stimulating relation to at least two nerves among the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and the stimulus generator is activated to generate the therapeutic stimulation signal to alleviate the pain under treatment. Alternatively, the therapeutic stimulation signal is selectively applied to at least one electrode implanted in stimulating relation to at least one of the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and if the selected nerve is the vagus nerve, the signal is applied to a supra-diaphragmatic or sub-diaphragmatic site, either unilaterally or bilaterally to one or both branches, respectively, of the vagus nerve.

摘要翻译： 公开了一种用于治疗患有严重，不懈疼痛的患者的方法和装置。 治疗刺激信号从被刺激发生器被激活时选择性地施加到在患者的三叉神经，迷走神经，舌咽和交感神经之间与至少两个神经刺激关系植入的多个电极中的至少一些，并且刺激发生器被激活 产生治疗刺激信号以减轻治疗期间的疼痛。 或者，将治疗刺激信号选择性地施加到植入与患者的三叉神经，迷走神经，舌咽和交感神经中的至少一个刺激关系的至少一个电极，并且如果选择的神经是迷走神经，则将信号施加到 分别为迷走神经的一个或两个分支单侧或双侧的膈上或膈下部位。

公开(公告)号：US06600954B2

公开(公告)日：2003-07-29

申请号：US09824682

申请日：2001-04-04

申请人： Ehud Cohen ,  Shai Ayal

发明人： Ehud Cohen ,  Shai Ayal

IPC分类号： A61N134

CPC分类号： A61N1/36071

摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a “green wave” effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.