公开(公告)号：US06721603B2

公开(公告)日：2004-04-13

申请号：US10055021

申请日：2002-01-25

申请人： Jacob Zabara ,  Burke T. Barrett ,  Steven M. Parnis

发明人： Jacob Zabara ,  Burke T. Barrett ,  Steven M. Parnis

IPC分类号： A61N134

CPC分类号： A61N1/36071

摘要： A method and apparatus are disclosed for treating patients suffering from severe, unrelenting pain. A therapeutic stimulation signal is selectively applied from a stimulus generator, when activated, to at least some of plural electrodes implanted in stimulating relation to at least two nerves among the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and the stimulus generator is activated to generate the therapeutic stimulation signal to alleviate the pain under treatment. Alternatively, the therapeutic stimulation signal is selectively applied to at least one electrode implanted in stimulating relation to at least one of the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and if the selected nerve is the vagus nerve, the signal is applied to a supra-diaphragmatic or sub-diaphragmatic site, either unilaterally or bilaterally to one or both branches, respectively, of the vagus nerve.

摘要翻译： 公开了一种用于治疗患有严重，不懈疼痛的患者的方法和装置。 治疗刺激信号从被刺激发生器被激活时选择性地施加到在患者的三叉神经，迷走神经，舌咽和交感神经之间与至少两个神经刺激关系植入的多个电极中的至少一些，并且刺激发生器被激活 产生治疗刺激信号以减轻治疗期间的疼痛。 或者，将治疗刺激信号选择性地施加到植入与患者的三叉神经，迷走神经，舌咽和交感神经中的至少一个刺激关系的至少一个电极，并且如果选择的神经是迷走神经，则将信号施加到 分别为迷走神经的一个或两个分支单侧或双侧的膈上或膈下部位。

公开(公告)号：US20200330782A1

公开(公告)日：2020-10-22

申请号：US16908990

申请日：2020-06-23

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61N2/00 ,  A61N2/02

摘要： An electromagnetic radiation treatment regime includes identifying a target area of a patient. In one embodiment, the target area is a virally-infected cell or tissue. An electromagnetic radiation source, for example, a low frequency and/or radio frequency electromagnetic radiation source, is selected, along with treatment session parameters, such as, pulse frequency, pulse duration, electrical current, magnetic flux density, and/or treatment session exposure time. An amount of electromagnetic radiation is applied to the target area, and a response to the electromagnetic radiation in the target area is measured. Based on an evaluation of the measured response, the treatment parameters may be modified for one or more subsequent electromagnetic radiation treatment session.

公开(公告)号：US20170189707A1

公开(公告)日：2017-07-06

申请号：US15338956

申请日：2016-10-31

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61N2/00 ,  A61N1/40 ,  A61N2/02

摘要： An electromagnetic radiation treatment regime includes identifying a target area of a patient. In one embodiment, the target area is the vagus nerve. An electromagnetic radiation source, for example, a low frequency and/or radio frequency electromagnetic radiation source, is selected, along with treatment session parameters, such as, pulse frequency, pulse duration, electrical current, magnetic flux density, and/or treatment session exposure time. An amount of electromagnetic radiation is applied to the target area, and a response to the electromagnetic radiation in the target area is measured. Based on an evaluation of the measured response, the treatment parameters may be modified for one or more subsequent electromagnetic radiation treatment session.

公开(公告)号：US20050182288A1

公开(公告)日：2005-08-18

申请号：US10780806

申请日：2004-02-18

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61B13/00 ,  A61N1/00 ,  A61N1/18 ,  A61N1/36 ,  A61N2/00

CPC分类号： A61N1/36082 ,  A61N1/36025 ,  A61N1/36053 ,  A61N2/006

摘要： Systems and methods for treating neuro-psychiatric disorders, such as depression or schizophrenia, and/or other illnesses are disclosed. A patient is diagnosed with a particular neuro-psychiatric disorder or other illness. An electric nerve stimulation (ENS) technique, such as vagus nerve stimulation (VNS), is administered to the patient in conjunction with a magnetic nerve stimulation (MNS) technique. The magnetic nerve stimulation (MNS) technique includes applying a magnetic field to a pre-selected synaptic region of a brain of the patient based on the diagnosis. A physiological response of the brain, such as electroencephalogram (EEG) activity, is monitored. One or more parameters of the magnetic field may be selectively adapted in response to the monitored physiological response. The administration of the ENS technique and the MNS technique may be performed simultaneously, in serial order, or in alternating order depending on the diagnosis.

摘要翻译： 公开了用于治疗神经精神障碍（如抑郁症或精神分裂症）和/或其他疾病的系统和方法。 患者被诊断患有特定的神经精神障碍或其他疾病。 结合磁神经刺激（MNS）技术向患者施用电神经刺激（ENS）技术，例如迷走神经刺激（VNS）。 磁神经刺激（MNS）技术包括基于诊断将磁场施加到患者的脑的预先选择的突触区域。 监测脑的生理反应，如脑电图（EEG）活动。 响应于所监测的生理响应，可以选择性地调节磁场的一个或多个参数。 ENS技术和MNS技术的管理可以按照连续的顺序或根据诊断以交替的顺序同时进行。

公开(公告)号：US5540734A

公开(公告)日：1996-07-30

申请号：US314173

申请日：1994-09-28

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/32

CPC分类号： A61N1/36167 ,  A61N1/36082 ,  A61N1/372 ,  A61N1/36025 ,  A61N1/36196

摘要： The treatment, control or prevention of medical, psychiatric or neurological disorders may be accomplished by application of modulating electric signals to one or both of a patient's trigeminal and glossopharyngeal nerves. The disorders treatable, controllable or preventable by such nerve stimulation include voluntary and involuntary disorders, migraine, epileptic seizure, motor disorders, Parkinson's disease, cerebral palsy, spasticity, chronic nervous illnesses and involuntary movement; pancreatic endocrine disorders including diabetes and hypoglycemia; dementia including cortical, subcortical, multi-infarct, Alzheimer's disease and Pick's disease; sleep disorders including central sleep apnea, insomnia and hypersomnia; eating disorders including anorexia nervosa, bulimia and compulsive overeating; and neuropsychiatric disorders including schizophrenia, depression and borderline personality disorder.

摘要翻译： 治疗，控制或预防医疗，精神疾病或神经障碍可以通过将电信号应用于患者的三叉神经和舌咽神经中的一者或两者来实现。 由这种神经刺激可治疗，可控制或可预防的疾病包括自愿和非自愿障碍，偏头痛，癫痫发作，运动障碍，帕金森病，脑瘫，痉挛，慢性神经疾病和非自愿运动; 胰腺内分泌疾病包括糖尿病和低血糖症; 痴呆包括皮层，皮质下，多梗死，阿尔茨海默病和皮克病; 睡眠障碍包括中枢性睡眠呼吸暂停，失眠和睡眠过多; 饮食失调包括神经性厌食症，食欲过猛和暴饮暴食; 神经精神障碍，包括精神分裂症，抑郁症和边缘人格障碍。

公开(公告)号：US09233257B1

公开(公告)日：2016-01-12

申请号：US14226055

申请日：2014-03-26

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61N2/00 ,  A61N2/12 ,  A61N1/40

CPC分类号： A61N2/002 ,  A61N1/40 ,  A61N2/004 ,  A61N2/02 ,  A61N2/12

摘要： An electromagnetic radiation treatment regime includes identifying a target area of a patient. An electromagnetic radiation source, for example, a low frequency and/or radio frequency electromagnetic radiation source, is selected, along with treatment session parameters, such as, pulse frequency, pulse duration, electrical current, magnetic flux density, and/or treatment session exposure time. An amount of electromagnetic radiation is applied to the target area, and a response to the electromagnetic radiation in the target area is measured. Based on an evaluation of the measured response, the treatment parameters may be modified for one or more subsequent electromagnetic radiation treatment session.

摘要翻译： 电磁辐射治疗方案包括识别患者的目标区域。 选择电磁辐射源，例如低频和/或射频电磁辐射源，连同处理会话参数，例如脉冲频率，脉冲持续时间，电流，磁通密度和/或治疗会话 曝光时间。 向目标区域施加电磁辐射量，并测量对目标区域中的电磁辐射的响应。 基于对测量的响应的评估，治疗参数可以针对一个或多个随后的电磁辐射治疗会话进行修改。

公开(公告)号：US08700163B2

公开(公告)日：2014-04-15

申请号：US11118451

申请日：2005-04-29

申请人： Reese S. Terry, Jr. ,  Jacob Zabara

发明人： Reese S. Terry, Jr. ,  Jacob Zabara

IPC分类号： A61N1/05

CPC分类号： A61N1/36089 ,  A61N1/36014 ,  A61N1/36053

摘要： A method of treating a patient with at least one substance addiction, which comprises directly stimulating a cranial nerve, such as the vagus nerve, of a patient with an electrical pulse signal defined by a plurality of parameters to provide a therapy regimen for alleviating a symptom associated with the substance addiction.

摘要翻译： 一种用至少一种物质成瘾来治疗患者的方法，其包括用多个参数定义的电脉冲信号直接刺激患者的颅神经，例如迷走神经，以提供减轻症状的治疗方案 与物质成瘾有关。

公开(公告)号：US5025807A

公开(公告)日：1991-06-25

申请号：US301111

申请日：1989-01-25

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36064 ,  A61N1/36053 ,  A61N1/36157 ,  A61N1/36167 ,  A61N1/372 ,  A61N1/36082

摘要： A neurocybernetic prosthesis for controlling or preventing epileptic seizures and other motor disorders includes a pulse generator which generates electrical pulses having a frequency of between 30 and 300 cycles per second, a pulse duration of between 0.3 and 1 millisecond and a constant current of between 1 and 20 milliamperes. The generator is enclosed in an epoxy-titanium shell and is implanted in the body, preferably in the axilla. Electrode leads pass from the generator through a subcutaneous tunnel and terminate in an electrode patch on the vagus nerve. Provisions are made for varying the electrical signal from the generator after it has been implanted to "tune" the same to the patient. The prosthesis may be designed to be turned on manually when the patient senses the imminence of a convulsion. Alternatively, sensors may be provided for determining changes in the values of state parameters such as electroencephalographic waves which precede a convulsion. The pulse generator can then be turned on automatically in response to the sensors.

摘要翻译： 用于控制或预防癫痫发作和其他运动障碍的神经运动假体包括脉冲发生器，该脉冲发生器产生频率在每秒30至300个周期之间的脉冲，脉冲持续时间在0.3和1毫秒之间，恒定电流在1和 20毫安。 发生器被封装在环氧钛壳中并且植入体内，优选植入腋窝。 电极引导从发生器通过皮下隧道，终止于迷走神经的电极贴片。 在将植入器件的电信号“调整”到患者身上之后，将对来自发生器的电信号进行改变。 假体可以设计成当患者感觉到惊厥的紧急时手动开启。 或者，可以提供传感器来确定状态参数的值的变化，例如在惊厥之前的脑电波。 然后可以响应于传感器自动打开脉冲发生器。

公开(公告)号：US09216290B2

公开(公告)日：2015-12-22

申请号：US13893292

申请日：2013-05-13

申请人： Jacob Zabara

发明人： Reese S. Terry, Jr. ,  Jacob Zabara

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/36089 ,  A61N1/36014 ,  A61N1/36053

摘要： A method of treating a patient with at least one substance addiction, which comprises directly stimulating a cranial nerve, such as the vagus nerve, of a patient with an electrical pulse signal defined by a plurality of parameters to provide a therapy regimen for alleviating a symptom associated with the substance addiction.

摘要翻译： 一种用至少一种物质成瘾来治疗患者的方法，其包括用多个参数定义的电脉冲信号直接刺激患者的颅神经，例如迷走神经，以提供减轻症状的治疗方案 与物质成瘾有关。

公开(公告)号：US07422555B2

公开(公告)日：2008-09-09

申请号：US10780806

申请日：2004-02-18

申请人： Jacob Zabara

发明人： Jacob Zabara

IPC分类号： A61B17/52 ,  A61N1/00

CPC分类号： A61N1/36082 ,  A61N1/36025 ,  A61N1/36053 ,  A61N2/006

摘要： Systems and methods for treating neuro-psychiatric disorders, such as depression or schizophrenia, and/or other illnesses are disclosed. A patient is diagnosed with a particular neuro-psychiatric disorder or other illness. An electric nerve stimulation (ENS) technique, such as vagus nerve stimulation (VNS), is administered to the patient in conjunction with a magnetic nerve stimulation (MNS) technique. The magnetic nerve stimulation (MNS) technique includes applying a magnetic field to a pre-selected synaptic region of a brain of the patient based on the diagnosis. A physiological response of the brain, such as electroencephalogram (EEG) activity, is monitored. One or more parameters of the magnetic field may be selectively adapted in response to the monitored physiological response. The administration of the ENS technique and the MNS technique may be performed simultaneously, in serial order, or in alternating order depending on the diagnosis.

摘要翻译： 公开了用于治疗神经精神障碍（如抑郁症或精神分裂症）和/或其他疾病的系统和方法。 患者被诊断患有特定的神经精神障碍或其他疾病。 结合磁神经刺激（MNS）技术向患者施用电神经刺激（ENS）技术，例如迷走神经刺激（VNS）。 磁神经刺激（MNS）技术包括基于诊断将磁场施加到患者的脑的预先选择的突触区域。 监测脑的生理反应，如脑电图（EEG）活动。 响应于所监测的生理响应，可以选择性地调节磁场的一个或多个参数。 ENS技术和MNS技术的管理可以按照连续的顺序或根据诊断以交替的顺序同时进行。