公开(公告)号：US20040232575A1

公开(公告)日：2004-11-25

申请号：US10485266

申请日：2004-02-10

Inventor： Dirk Wulff ,  Ekkehard Jahns ,  Volker Schehlmann

IPC: B01J013/02 ,  B01J013/04

CPC classification number: C08G18/36 ,  B01J13/16 ,  C08G18/2825 ,  C08G18/3228 ,  Y10T428/2985 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998

Abstract: The present invention relates to microcapsule dispersions comprising microcapsules having a capsule core comprising water-soluble organic substances, and a capsule coating which essentially consists of polyurethane and/or polyurea, in a hydrophobic solvent which consists of 50 to 100% by weight of glycerol ester oils and 0 to 50% by weight of solvents miscible with glycerol ester oils, and to a process for their preparation.

Abstract translation: 本发明涉及包含微胶囊的微囊分散体，所述微胶囊具有包含水溶性有机物质的胶囊核心，以及疏水溶剂中的基本上由聚氨酯和/或聚脲组成的胶囊涂层，所述疏水溶剂由50至100重量％的甘油酯 油和0至50重量％与甘油酯油混溶的溶剂，以及其制备方法。

公开(公告)号：US20040195711A1

公开(公告)日：2004-10-07

申请号：US10800866

申请日：2004-03-16

Inventor： Masaki Hayashi ,  Mitsuru Furomoto

IPC: B01J013/02 ,  B01J013/04 ,  B01J013/20

CPC classification number: B01J13/14 ,  G02F2001/1678 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2991

Abstract: A microcapsule encapsulating a disperse system is produced by preparing a liquid organic dispersion containing a resin whose acid group has been neutralized, a colored particle, and an organic solvent; dispersing the liquid organic dispersion in an aqueous medium to produce a capsule particle in the aqueous medium, the capsule particle comprising a disperse system in which the colored particle is dispersed in the organic solvent, and a wall encapsulating the disperse system; and separating the capsule particle from the aqueous medium for dryness. The liquid organic dispersion may comprise, as an organic solvent, a hydrophobic organic solvent and a polar solvent dissolving the resin constituting the wall and being miscible to the aqueous medium. The wall of the capsule particle may be crosslinked or cured with a crosslinking agent. The microcapsule is utilized for an image display device in which the colored particle is electrophoretically movable in the oil phase by a potential difference. The present invention provides a microcapsule encapsulating a core material in which a colored particle is dispersed in an oil phase and having a uniform particle size without an emulsifying and dispersing agent.

Abstract translation: 包封分散系统的微胶囊通过制备含有酸基被中和的树脂的液体有机分散体，着色颗粒和有机溶剂来制备; 将液体有机分散体分散在水性介质中以在水性介质中产生胶囊颗粒，所述胶囊颗粒包含其中着色颗粒分散在有机溶剂中的分散体系和包封分散体系的壁; 并将胶囊颗粒与水性介质分离干燥。 液体有机分散体可以包含作为有机溶剂的疏水性有机溶剂和溶解构成壁的树脂并与水性介质混溶的极性溶剂。 胶囊颗粒的壁可以交联或用交联剂固化。 微胶囊用于图像显示装置，其中着色颗粒在油相中电泳可移动电位差。 本发明提供了一种包封芯材的微胶囊，其中着色颗粒分散在油相中，并且具有均匀的粒度而没有乳化分散剂。

公开(公告)号：US20040013738A1

公开(公告)日：2004-01-22

申请号：US10343583

申请日：2003-01-31

Inventor： Andreas Voigt ,  Sukhorukov Gleb ,  Alexei Antipov ,  Edwin Donath ,  Horst Seibt

IPC: A01N025/28 ,  A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K9/5192 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5138 ,  B01J13/02 ,  B01J13/10 ,  B01J13/22 ,  Y10T428/2984

Abstract: The invention relates to a method for applying a shell to liquid template particles, comprising the following steps: (a) preparation of an emulsion of liquid template particles in a continuous liquid or gel phase, whereby at least one amphiphilic polyelectrolyte or polyelectrolyte complex, or a copolymer of charged hydrophilic monomers and oil soluble monomers is dissolved in the fluid template particles and/or the continuous phase and a film is formed at the phase boundary between the liquid template particle and the continuous phase and (b) application of a shell to the film formed at the phase boundary.

Abstract translation: 本发明涉及一种将壳体施用于液体模板颗粒的方法，包括以下步骤：（a）在连续的液体或凝胶相中制备液体模板颗粒的乳液，由此至少一种两亲性聚电解质或聚电解质复合物，或 带电的亲水单体和油溶性单体的共聚物溶解在流体模板颗粒和/或连续相中，并且在液体模板颗粒和连续相之间的相界面处形成膜，（b）将壳施加到 该膜在相界处形成。

公开(公告)号：US20030180369A1

公开(公告)日：2003-09-25

申请号：US10381553

申请日：2003-03-25

Inventor： Philippe Grisoni

IPC: A61K009/14 ,  A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K8/11 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/04 ,  Y10S514/938 ,  Y10S514/951 ,  Y10S514/963 ,  Y10S514/965

Abstract: A process for making hydrophobicized powders of micro- and/or nanocapsules involving the steps of: (a) providing an aqueous polymer solution containing at least one active ingredient and at least one hydrophilic polymer; (b) providing an oil component heated to a temperature above a gel point of the aqueous polymer solution; (c) dispersing (a) in (b) in the presence of a water-in-oil emulsifier to form a dispersion; (d) cooling the dispersion to a temperature below the gel point of the aqueous polymer solution to form micro- and/or nanocapsules containing the active ingredient encapsulated therein; (e) harvesting the micro- and/or nanocapsules from the dispersion; and (f) contacting the micro- and/or nanocapsules with an oil-absorbing auxiliary ingredient.

Abstract translation: 一种制备疏水化的微米和/或纳米胶囊的粉末的方法，包括以下步骤：（a）提供含有至少一种活性成分和至少一种亲水性聚合物的聚合物水溶液; （b）提供加热到高于聚合物水溶液凝胶点的温度的油组分; （c）在油包水乳化剂存在下分散（a）在（b）中以形成分散体; （d）将分散体冷却至低于聚合物水溶液凝胶点的温度，以形成包含其中包含活性成分的微米和/或纳米胶囊; （e）从分散体中收获微米和/或纳米胶囊; 和（f）使微型和/或纳米胶囊与吸油辅助成分接触。

公开(公告)号：US20030170313A1

公开(公告)日：2003-09-11

申请号：US10356139

申请日：2003-01-31

Inventor： Ales Prokop

IPC: A61K009/14 ,  A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K9/5161 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5169 ,  A61K9/5192

Abstract: The present invention provides a method of making particles, e.g., nanoparticles that are stable in a physiological environment for at least a day. The nanoparticles comprise polyanionic polymers and polycations in a complex useful for drug delivery. The method comprises the step of capturing droplets comprising the polyanionic polymers in a solution comprising the polycations; or, alternatively, capturing droplets comprising the polycations in a solution comprising the polyanionic polymers. Also provided are methods of use for the particles.

Abstract translation: 本发明提供了一种制备颗粒的方法，例如在生理环境中稳定至少一天的纳米颗粒。 纳米颗粒包含用于药物递送的复合物中的聚阴离子聚合物和聚阳离子。 该方法包括在包含聚阳离子的溶液中捕获包含聚阴离子聚合物的液滴的步骤; 或者，替代地，在包含聚阴离子聚合物的溶液中捕获包含聚阳离子的液滴。 还提供了用于颗粒的方法。

公开(公告)号：US20030129247A1

公开(公告)日：2003-07-10

申请号：US10207199

申请日：2002-07-30

Inventor： Hee Kyung Ju ,  Jin Woong Kim ,  Sang Hoon Han ,  Ih Seop Chang ,  Han Kon Kim ,  Hak Hee Kang ,  Ok Sub Lee

IPC: A61K009/48 ,  A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: B01J13/16 ,  A61K8/0295 ,  A61K8/11 ,  A61K8/8147 ,  A61K2800/412 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q19/00

Abstract: There are provided thermotropic liquid crystal polymer microcapsules which can show behavior of liquid crystal as it is within polymer phase due to phase separation between liquid crystal and polymer, so to be incorporated into cosmetic composition as an additive for visual effect, and in loading active ingredients within liquid crystal, can improve the stability of the active ingredients in cosmetic base; and a method for preparing the same; and cosmetic compositions containing the same.

Abstract translation: 提供了热液晶聚合物微胶囊，由于液晶和聚合物之间的相分离，其可以显示液晶在聚合物相内的行为，因此可以作为视觉效果的添加剂加入到化妆品组合物中，并且加载活性成分 在液晶中，可以提高化妆品基质中活性成分的稳定性; 及其制备方法。 和含有它们的化妆品组合物。

公开(公告)号：US20020158356A1

公开(公告)日：2002-10-31

申请号：US10128280

申请日：2002-04-24

Inventor： Jean-Francois Argillier ,  Maria-Lidice Soto-Portas ,  Nathalie Zydowicz ,  Francoise Mechin ,  Angele Chomard

IPC: B01J013/02 ,  B01J013/04

CPC classification number: B01J13/16 ,  Y10T428/2985

Abstract: The present invention relates to a process of obtaining microcapsules, comprising mainly the following stages: preparing a scarcely water-soluble organic phase containing a determined amount of acid chlorides, forming an emulsion of said organic phase in an aqueous phase, adding to the aqueous emulsion an amount of at least one polyoxyalkylene polyamine, reacting the monomers containing the amine and acid chloride functions so as to form a polyamide membrane around the emulsified organic phase, recovering the microcapsules obtained. The present invention also relates to a microcapsule.

Abstract translation: 本发明涉及一种获得微胶囊的方法，主要包括以下阶段：制备含有确定量的酰氯的几乎不溶于水的有机相，在水相中形成所述有机相的乳液，加入水性乳液 至少一种聚氧化烯多胺，使含有胺和酰氯的单体反应，以在乳化的有机相周围形成聚酰胺膜，回收得到的微胶囊。 本发明还涉及一种微胶囊。

公开(公告)号：US20020155090A1

公开(公告)日：2002-10-24

申请号：US10075621

申请日：2002-02-15

Applicant: SHOWA DENKO K.K.

Inventor： Ryuji Takahashi ,  Kazunori Iwata

IPC: A61K031/74 ,  A61K009/50 ,  B01J013/04

CPC classification number: B01J20/291 ,  B01D15/34 ,  B01J20/26 ,  B01J20/261 ,  B01J20/285 ,  B01J2220/54

Abstract: A hydrophilic separating carrier particle comprising a copolymerized hydrophilic monomer and hydrophilic crosslinkable monomer, and a process of producing thereof is disclosed.

Abstract translation: 公开了包含共聚亲水性单体和亲水性交联性单体的亲水性分离载体颗粒及其制备方法。

公开(公告)号：US20020127278A1

公开(公告)日：2002-09-12

申请号：US09874637

申请日：2001-06-05

Inventor： James E. Kipp ,  Joseph Chung Tak Wong ,  Mark J. Doty ,  Christine L. Rebbeck

IPC: A61K031/727 ,  A61K009/14 ,  B01J013/04

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K31/495 ,  A61K31/496 ,  Y10T428/2984 ,  Y10T428/2985

Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.

公开(公告)号：US20020114844A1

公开(公告)日：2002-08-22

申请号：US10004522

申请日：2001-11-01

Inventor： Mazen H. Hanna ,  Peter York

IPC: A61K009/16 ,  A61K009/50 ,  B01J013/04

CPC classification number: A23L5/30 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/00 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/167 ,  A61K9/1694 ,  B01D9/0054

Abstract: Preparation of particles of an active substance having a layer of an additive at the particle surfaces, by dissolving both the active substance and the additive in a vehicle to form a target solution, and contacting the target solution with an anti-solvent fluid using a SEDSnull particle formation process, to cause the active substance and additive to coprecipitate. The additive is typically a protective additive, in particular a taste and/or odour masking agent. Also provided is a particulate coformulation made by the method, which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the active-rich core to the additive-rich surface of the particles.

Abstract translation: 通过将活性物质和添加剂同时溶解在载体中以形成目标溶液，并且使用SEDS将目标溶液与抗溶剂流体接触来制备在颗粒表面具有添加剂层的活性物质的颗粒 （TM）颗粒形成过程，使活性物质和添加剂共沉淀。 添加剂通常是保护性添加剂，特别是味道和/或气味掩蔽剂。 还提供了通过该方法制备的颗粒共同制剂，其在相对添加剂浓度中具有有限的梯度，该浓度从富活性核心向颗粒的富含添加剂的表面径向向外增加。