公开(公告)号：US07195820B2

公开(公告)日：2007-03-27

申请号：US10980720

申请日：2004-11-03

Applicant: Sheng Hong ,  Rosangela Pirri ,  Brian Edgecombe

Inventor： Sheng Hong ,  Rosangela Pirri ,  Brian Edgecombe

IPC: A61K9/50 ,  B01J13/03 ,  B32B5/16

CPC classification number: C08L51/04 ,  C08F265/06 ,  C08F285/00 ,  Y10T428/2989 ,  C08F2/22

Abstract: The present invention relates to core-shell polymers having a hydrophilic copolymer shell, and a high level of core material of from 75 to 95 weight percent. The hydrophilic shell provides better coverage of the core resulting in better powder properties such as anti-blocking. The hydrophilic shell also allows for a thinner shell and a larger elastomeric core. Core-shell polymers of the invention are especially useful as impact modifiers for plastic materials.

Abstract translation: 本发明涉及具有亲水共聚物壳的核 - 壳聚合物和75-95重量％的高含量的芯材。 亲水壳提供更好的芯的覆盖，导致更好的粉末性质，如防粘连。 亲水外壳还允许更薄的外壳和更大的弹性体芯。 本发明的核 - 壳聚合物特别用作塑料材料的抗冲改性剂。

公开(公告)号：US5753519A

公开(公告)日：1998-05-19

申请号：US467004

申请日：1995-06-06

Applicant: Richard Allen Durst ,  Matthew A. Roberts

Inventor： Richard Allen Durst ,  Matthew A. Roberts

IPC: G01N33/543 ,  G01N33/558 ,  G01N33/58 ,  G01N33/53 ,  C25B1/00 ,  B01J13/03

CPC classification number: G01N33/586 ,  G01N33/54313 ,  G01N33/5438 ,  G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/815

Abstract: A test device for detecting or quantifying an analyte in a test sample includes an absorbent material having separate contact and measurement portions. The contact portion is positioned at or proximate to a first end of the absorbent material. The measurement portion has a receptor for a conjugate of an analyte analog and marker-encapsulating liposomes. In a method for using the test device, a binding material specific for the analyte is combined with the liposome-analyte analog conjugate and the test sample to form a test mixture. The mixture is incubated for a time sufficient to permit competition between any analyte present and the conjugate for the binding material. Following incubating, the mixture is allowed to traverse the absorbent material from the contact portion through the measurement portion of the absorbent material. Following traversal by the test mixture, the presence or amount of marker in the measurement portion of the absorbent material is then detected and correlated with the presence or amount, respectively, of the analyte in the sample. Also disclosed are liposomes encapsulating an electroactive marker used in conjunction with a test device as described, but which includes an electrochemical measurement portion in place of the measurement portion described above. Test devices and methods employing electrochemical detection or quantification of an electroactive marker corresponding to the amount of analyte in a sample may be either amperometric or potentiometric.

Abstract translation: 用于检测或定量测试样品中的分析物的测试装置包括具有单独的接触和测量部分的吸收材料。 接触部分位于或接近吸收材料的第一端。 测量部分具有用于分析物类似物和标记包封脂质体的缀合物的受体。 在使用测试装置的方法中，将特异于分析物的结合材料与脂质体 - 分析物类似物缀合物和测试样品组合以形成测试混合物。 将混合物温育足以允许存在的任何分析物与用于结合材料的缀合物之间的竞争。 孵育后，允许混合物通过吸收材料的测量部分从接触部分穿过吸收材料。 在通过测试混合物穿过之后，然后检测吸收材料的测量部分中的标记物的存在或量，并分别与样品中分析物的存在或数量相关联。 还公开了包封与如上所述的测试装置结合使用的电活性标记的脂质体，但是包括电化学测量部分代替上述测量部分。 使用对应于样品中分析物的量的电活性标记的电化学检测或定量的测试装置和方法可以是电流式或电位式的。