公开(公告)号：US20040116725A1

公开(公告)日：2004-06-17

申请号：US10319910

申请日：2002-12-13

申请人： Clariant International, Ltd.

发明人： Wolf-Dieter Mueller ,  Peter Naumann

IPC分类号： C07C39/29

CPC分类号： C07C303/32 ,  C07C303/22 ,  C07C309/42

摘要： The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfonates can be prepared in high yields and good grades, irrespective of the grade or reactivity of the phenolsulfonic acid derivative, if the reaction of the phenolsulfonic acid with an alkanecarboxylic acid derivative is carried out in an aliphatic or aromatic solvent in the presence of 0.5 to 25% by weight of a polyglycol ether.

公开(公告)号：US20020193628A1

公开(公告)日：2002-12-19

申请号：US10153908

申请日：2002-05-24

申请人： SIEMENS AXIVA GmbH & CO. KG

发明人： Rainald Forbert ,  Thomas Diehl

IPC分类号： C07C39/29

CPC分类号： C07C303/44 ,  C07C309/31 ,  C07C309/42

摘要： A process for recovering and purifying substituted benzenesulfonates, by neutralizing a mixture including at least one substituted benzenesulfonate, or at least one corresponding substituted benzenesulfonic acid, and sulfur trioxide, sulfuric acid and/or hydrogen chloride in free or bound form, in an aqueous phase using an alkali metal hydroxide, and purifying it in this aqueous phase, and by subsequently separating the substituted benzenesulfonate(s) from this aqueous phase. The mixture is comminuted into particles having a Sauter mean diameter in the range from 1 nullm to 2 cm, either before or during introduction into this aqueous phase.

摘要翻译： 通过在水相中中和包含至少一种取代的苯磺酸盐或至少一种相应的取代的苯磺酸的混合物，以及游离或结合形式的三氧化硫，硫酸和/或氯化氢来回收和纯化取代的苯磺酸盐的方法 使用碱金属氢氧化物，并在该水相中纯化，并随后从该水相中分离出取代的苯磺酸盐。 在引入该水相之前或期间，将该混合物粉碎成具有在1mum至2cm范围内的沙特平均直径的颗粒。

公开(公告)号：US20040138502A1

公开(公告)日：2004-07-15

申请号：US10469824

申请日：2004-02-25

发明人： Stephen F Traynelis ,  Dennis C Liotta ,  James P Snyder ,  Yesim Altas ,  David D Mott ,  James J Doherty JR. ,  Raymond J Dingledine

IPC分类号： C07C39/29

CPC分类号： C07C217/34 ,  C07C311/08 ,  C07C311/21 ,  C07D263/24

摘要： NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or spinal cord tissue. Compositions and methods of this invention are used for treating neurodegeneration resulting from NMDA receptor activation. The compounds described herein have enhanced activity in brain tissue having lower-than normal pH due to pathological conditions such as hypoxia resulting from stroke, traumatic brain injury, global ischemia tat may occur during cardiac surgery, hypoxia tat may occur following cessation of breathing, pre-eclampsia, spinal cord trauma, epilepsy, chronic pain, vascular dementia and glioma tumors. Compounds described herein are also useful in preventing neurodegeneration in patients with Parkinson's Alzheimer's, Huntington's chorea, ALS, and other neurodegenerative conditions known to the art to be responsive to treatment using NMDA receptor blockers. Preferably the compounds provided herein are allosteric NMDA inhibitors.

摘要翻译： 提供NMDA受体阻滞剂，包括pH敏感的NMDA受体阻断剂，作为神经保护药物，其可用于中风，创伤性脑损伤，癫痫和涉及脑或脊髓组织酸化的其它神经系统事件。 本发明的组合物和方法用于治疗由NMDA受体活化引起的神经变性。 本文所述的化合物由于病理状况如卒中引起的缺氧，外伤性脑损伤，全身缺血，可能在心脏手术期间发生，可能会在呼吸停止后发生缺氧，因此具有低于正常pH值的脑组织中的活性增强。 癫痫，脊髓创伤，癫痫，慢性疼痛，血管性痴呆和神经胶质瘤。 本文所述的化合物还可用于预防帕金森氏老年痴呆症，亨廷顿舞蹈症，ALS患者和本领域已知的对NMDA受体阻断剂治疗有反应的其它神经变性病症患者的神经变性。 优选地，本文提供的化合物是变构NMDA抑制剂。

公开(公告)号：US20030097030A1

公开(公告)日：2003-05-22

申请号：US10218732

申请日：2002-08-14

发明人： Peter Arnoldy

IPC分类号： C07C029/04 ,  C07C39/29 ,  B01J008/04

CPC分类号： C07C303/06 ,  C07C5/2767 ,  C07C7/148 ,  C07C11/02 ,  C07C15/107 ,  C07C309/31

摘要： A process for producing branched olefins from a mixed linear olefin/paraffin isomerisation feed comprising linear olefins having at least 7 carbon atoms in 5-50% w comprising in a first stage skeletally isomerising linear olefins in the isomerisation feed and in a second stage separating branched and linear molecules wherein branched molecules are substantially olefinic and linear molecules are olefinic and/or paraffinic; novel stages and combinations thereof; apparatus therefor; use of catalysts and the like therein; and use of branched olefins obtained thereby.

公开(公告)号：US20050080135A1

公开(公告)日：2005-04-14

申请号：US10682004

申请日：2003-10-08

申请人： Nirmal Koshti ,  Shubhangi Naik ,  Bharat Parab ,  Tanaji Jadhav ,  Subhash Nashte

发明人： Nirmal Koshti ,  Shubhangi Naik ,  Bharat Parab ,  Tanaji Jadhav ,  Subhash Nashte

IPC分类号： A61K31/205 ,  C07C231/12 ,  C07C235/34 ,  C07C237/36 ,  C07C39/29

CPC分类号： A61K31/205 ,  C07C231/12 ,  C07C235/34 ,  C07C237/36

摘要： An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in making fabric care products and personal care products. The scope of this methodology has been demonstrated by converting water soluble organic sunscreen quaternary halides to their corresponding tosylates of Formula VI.

摘要翻译： 已经描述了用于制造肉豆蔻酰烷基胺和/或苯甲酰胺基烷基胺的甲苯磺酸盐季铵盐的有效，简单，高产，环保的方法（式I）。 这些化合物是实质的紫外线吸收剂。 它们可用于制作织物护理产品和个人护理产品。 通过将水溶性有机防晒季铵盐转化成其相应的式VI的甲苯磺酸酯已经证明了该方法的范围。

公开(公告)号：US20020022743A1

公开(公告)日：2002-02-21

申请号：US09755619

申请日：2001-01-05

发明人： Sergei Pouhov ,  Gene Jamieson ,  John Vajda ,  Henry Kruk ,  John McGinley

IPC分类号： C07C39/29

CPC分类号： C07C303/44 ,  C07C309/44

摘要： Solid aryl sulfonates are purified by preferentially dissolving impurities into an aqueous liquid phase.

摘要翻译： 通过优先将杂质溶解到水性液相中来纯化固体芳基磺酸盐。

公开(公告)号：US20020007083A1

公开(公告)日：2002-01-17

申请号：US09827990

申请日：2001-04-06

申请人： 3M Innovative Properties Company

发明人： Darryl D. DesMarteau ,  Charles W. Martin ,  Lawrence A. Ford ,  Yuan Xie

IPC分类号： C07C39/29 ,  C07C39/86

CPC分类号： C08F16/32 ,  C07C309/87 ,  C07C311/48 ,  C07C2601/04

摘要： The present invention provides a monomer having the formula A-B, wherein A is represented by Formula I: 1 wherein B is selected from nullOCFnullCF2 and nullA; wherein, when B isnullOCFnullCF2, the orientation of B is meta or para to the trifluorovinyloxy group of A; wherein, when B is A, the bond joining the A groups is para to the trifluorovinyloxy group of each A; and wherein each Z is independently selected from nullSO2F, nullSO2Cl, nullSO3H, nullSO2nullN(M)nullSO2CF3, and nullSO2nullN(M)nullSO2Rf; wherein M is any suitable cation and Rf is a Cl to CIO fluorocarbon or fluorinated ether group. The present invention also provides a monomer according to Formula II: 2 wherein X is F, Cl, or N(M)SO2Rf, wherein M is any suitable cation and Rf is a C1 to C10 fluorocarbon or fluorinated ether group.

摘要翻译： 本发明提供具有式A-B的单体，其中A由式I表示：其中B选自-OCF = CF 2和-A; 其中当B为-OCF = CF 2时，B的取向为A的三氟乙烯氧基的间位或对位; 其中，当B为A时，连接A基团的键对于每个A的三氟乙烯基氧基; 并且其中每个Z独立地选自-SO 2 F，-SO 2 Cl，-SO 3 H，-SO 2 -N（M）-SO 2 CF 3和-SO 2 -N（M）-SO 2 R f; 其中M是任何合适的阳离子，Rf是Cl至CIO氟代烃或氟化醚基团。 本发明还提供了根据式II的单体：其中X是F，Cl或N（M）SO 2 R f，其中M是任何合适的阳离子，Rf是C1至C10碳氟化合物或氟化醚基团。