公开(公告)号：US06670406B2

公开(公告)日：2003-12-30

申请号：US10077855

申请日：2002-02-19

Applicant: Jörg Hofmann ,  Stephan Ehlers ,  Bernd Klinksiek ,  Bert Klesczewski ,  Christian Steinlein ,  Lars Obendorf ,  Harald Pielartzik ,  Jose F. Pazos

Inventor： Jörg Hofmann ,  Stephan Ehlers ,  Bernd Klinksiek ,  Bert Klesczewski ,  Christian Steinlein ,  Lars Obendorf ,  Harald Pielartzik ,  Jose F. Pazos

IPC: C07C4311

CPC classification number: B01J19/2465 ,  C08G65/2663 ,  C08G65/2696

Abstract: The present invention relates to a process for the production of a polyether polyol by polyaddition of an alkylene oxide onto a starter compound containing active hydrogen atoms conducted in the presence of a double metal cyanide catalyst comprising conducting a reaction mixture at least once through a zone which has an energy density of at least 5×106 J/m3, wherein the dwell time of the reaction mixture in this zone is at least 10−6 seconds per pass.

Abstract translation: 本发明涉及一种生产聚醚多元醇的方法，该方法是通过在双金属氰化物催化剂的存在下将烯化氧加成到含有活性氢原子的起始化合物上，包括将反应混合物至少一次通过一个 具有至少5×10 6 J / m 3的能量密度，其中该区域中反应混合物的停留时间为每次通过至少10 -6秒。

公开(公告)号：US06620976B2

公开(公告)日：2003-09-16

申请号：US10106219

申请日：2002-03-27

Applicant: Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

Inventor： Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

IPC: C07C4311

CPC classification number: C08G65/2609 ,  C08L2203/02

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢   ⁢ ( ppm ) = 150 × 2900 × 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.

Abstract translation: 聚乙二醇用于应用于生物体的领域，其中聚乙二醇中乙二醇和二甘醇的含量之和小于或等于下式[I]表示：其中x表示平均分子量 聚乙二醇的重量，聚乙二醇的平均分子量为190〜1050。

公开(公告)号：US06495727B1

公开(公告)日：2002-12-17

申请号：US09831117

申请日：2001-05-04

Applicant: Glenn Thomas Jordan, IV ,  Larry Eugene Miller ,  Donald Eugene Levengood ,  Mark Robert Sivik ,  Bernard William Kluesener ,  Terry Franklin Formyduval ,  Deborah Jean Back

Inventor： Glenn Thomas Jordan, IV ,  Larry Eugene Miller ,  Donald Eugene Levengood ,  Mark Robert Sivik ,  Bernard William Kluesener ,  Terry Franklin Formyduval ,  Deborah Jean Back

IPC: C07C4311

CPC classification number: B01F17/0028 ,  C08G65/22 ,  C08G65/2609 ,  C08G2650/06 ,  C08G2650/34 ,  C11D1/721

Abstract: A process for preparing an ether-capped poly(oxyalkylated) alcohol surfactant having the formula R1O[CH2CH(R3)O]xCH2CH(OH)CH2OR2 wherein R1 and R2 are linear or branched, saturated or unsaturated, aliphatic or aromatic hydrocarbon radicals having from 1 to about 30 carbon atoms; R3 is H, or a linear aliphatic hydrocarbon radical having from 1 to about 4 carbon atoms; x is an integer having an average value from 1 to about 30, wherein when x is about 2 or greater R3 may be the same or different; further wherein when x is about 15 or greater and R3 is H and methyl, at least four of R3 are methyl, further wherein when x is about 15 or greater and R3 includes H and from 1 to 3 methyl groups, then at least one R3 is ethyl, propyl or butyl, further wherein R2 can optionally be alkoxylated, wherein said alkoxy is selected from ethoxy, propoxy, butoxy and mixtures thereof; said process comprising the steps of: (b) providing a glycidyl ether having the formula:  wherein R2 is defined as above; (c) providing an ethoxylated alcohol having the formula:  wherein R1, R3 and x are defined as above; (f) reacting said glycidyl ether with said ethoxylated alcohol to form said surfactant in the presence of a basic catalyst; (g) said surfactant is sparged with an inert gas, preferably N2, Ar and mixtures thereof, optionally under vacuum, preferably a vacuum in the range of 5 to 500 mmHg; and said surfactant is bleached with an about 0.05% to about 5.0%, preferably about 0.1% to about 1.0%, by weight solution of a bleach at a temperature from about 25° C. to about 95° C.

Abstract translation: 制备具有式R 1和R 2的醚的聚（烷氧基化）醇表面活性剂的方法是具有1至约30个碳原子的直链或支链，饱和或不饱和的脂族或芳族烃基; R3是H或具有1至约4个碳原子的直链脂族烃基; x是平均值为1至约30的整数，其中当x为约2或更大时，R 3可以相同或不同; 其中当x为约15或更大且R 3为H和甲基时，R 3中的至少4个为甲基，此外，当X为约15或更大且R 3包括H和1至3个甲基时，则至少一个R 3 乙基，丙基或丁基，其中R 2可任选地被烷氧基化，其中所述烷氧基选自乙氧基，丙氧基，丁氧基及其混合物; 所述方法包括以下步骤：（b）提供具有下式的缩水甘油醚：其中R2如上定义;（c）提供具有下式的乙氧基化醇：其中R1，R3和x如上定义;（f） 使所述缩水甘油醚与所述乙氧基化醇反应以在碱性催化剂存在下形成所述表面活性剂;（g）任选地在真空下，优选在该范围内的真空下，用惰性气体，优选N 2，Ar及其混合物喷射所述表面活性剂 为5〜500mmHg; 漂白剂在约25℃至约95℃的温度下漂白约0.05％至约5.0％，优选约0.1％至约1.0％的漂白剂。

公开(公告)号：US06469217B2

公开(公告)日：2002-10-22

申请号：US09845888

申请日：2001-04-30

Applicant: Satoru Saito ,  Haruyoshi Tatsu ,  Vera Grinevskaya

Inventor： Satoru Saito ,  Haruyoshi Tatsu ,  Vera Grinevskaya

IPC: C07C4311

CPC classification number: B01J31/0232 ,  B01J31/0209 ,  B01J2231/48 ,  C08G65/226 ,  C08G65/2639

Abstract: The polymerization initiator-containing solution obtained by mixing a specific perfluorodicarboxylic acid fluoride (A) with CsF in an aprotic polar solvent with stirring to conduct reaction and thereby form a polymerization initiator (B) and then allowing the reaction solution to stand for not less than 72 hours at a temperature of 0 to 30° C. A polymerization initiator-containing solution comprises a specific polymerization initiator (B′) and an aprotic polar solvent. The process for preparing a perfluoropolyether comprises polymerizing hexafluoropropylene oxide in the presence of the polymerization initiator-containing solution.

Abstract translation: 通过在搅拌下将特定的全氟二羧酸氟化物（A）与CsF混合在搅拌下得到的含聚合引发剂的溶液进行反应，从而形成聚合引发剂（B），然后使反应溶液静置不少于 在0〜30℃的温度下72小时。含聚合引发剂的溶液包含特定的聚合引发剂（B'）和非质子极性溶剂。 制备全氟聚醚的方法包括在含聚合引发剂的溶液的存在下聚合六氟环氧丙烷。

公开(公告)号：US06376645B1

公开(公告)日：2002-04-23

申请号：US09574925

申请日：2000-05-19

Applicant: David E. Laycock ,  Kendra L. Flagler ,  Robert J. Gulotty, Jr.

Inventor： David E. Laycock ,  Kendra L. Flagler ,  Robert J. Gulotty, Jr.

IPC: C07C4311

CPC classification number: C08G65/2663 ,  B01J27/26

Abstract: Metal [hexacyanometallate hexanitrometallate] complexes are useful alkylene oxide polymerization catalysts. The metal is any that forms a precipitate with hexacyanometallate and hexanitrometallate groups. These catalysts are made from less expensive raw materials than the common zinc hexacyanocobaltate catalysts, and provide short induction periods and in many cases more controlled exotherms.

Abstract translation: 金属[hexacyanometallate hexanitrometallate]复合物是有用的环氧烷聚合催化剂。 金属是任何与六氰基金属盐酸盐和己氮铝酸盐基团形成沉淀物的金属。 这些催化剂由比普通的六氰合钴酸锌催化剂更便宜的原料制成，并且提供短的诱导期，并且在许多情况下是更受控制的放热。

公开(公告)号：US06323375B1

公开(公告)日：2001-11-27

申请号：US09509979

申请日：2000-04-05

Applicant: Jörg Hofmann ,  Pramod Gupta ,  Robert-Joseph Kumpf ,  Pieter Ooms ,  Walter Schäfer ,  Michael Schneider

Inventor： Jörg Hofmann ,  Pramod Gupta ,  Robert-Joseph Kumpf ,  Pieter Ooms ,  Walter Schäfer ,  Michael Schneider

IPC: C07C4311

CPC classification number: C08G65/2663 ,  B01J27/26

Abstract: The present invention relates to highly active, substantially crystalline double metal cyanide (DMC) catalysts, a process for the preparation of these double metal cyanide catalysts, a process for producing polyether polyols by the polyaddition of alcohol ethers onto starter compounds containing active hydrogen atoms from these DMC catalysts, and to the polyether polyols produced by this process. The DMC catalysts of the invention comprise a) double metal cyanide compounds, b) organic complexing ligands, and c) functionalized polymers. These catalysts exhibit increased activity in the process for the production of polyether polyols.

Abstract translation: 本发明涉及高活性，基本上结晶的双金属氰化物（DMC）催化剂，制备这些双金属氰化物催化剂的方法，通过将醇醚加成到含有活性氢原子的起始化合物上制备聚醚多元醇的方法 这些DMC催化剂，以及通过该方法制备的聚醚多元醇。 本发明的DMC催化剂包括a）双金属氰化物化合物，b）有机络合配体，和c）官能化聚合物。 这些催化剂在制备聚醚多元醇的方法中表现出增加的活性。

公开(公告)号：US06756512B2

公开(公告)日：2004-06-29

申请号：US10258900

申请日：2002-10-30

Applicant: Walter Hübsch ,  Reinhard Lantzsch ,  Thorsten Müh ,  Holger Weintritt

Inventor： Walter Hübsch ,  Reinhard Lantzsch ,  Thorsten Müh ,  Holger Weintritt

IPC: C07C4311

CPC classification number: C07C37/02 ,  C07C37/055 ,  C07C39/28

Abstract: The invention relates to a novel process for preparing 2-alkyl-3-chlorophenols.

Abstract translation: 本发明涉及一种制备2-烷基-3-氯苯酚的新方法。

公开(公告)号：US06683222B2

公开(公告)日：2004-01-27

申请号：US09942713

申请日：2001-08-31

Applicant: Takeshi Nakamura ,  Masatsugu Yamashita

Inventor： Takeshi Nakamura ,  Masatsugu Yamashita

IPC: C07C4311

CPC classification number: A61K8/39 ,  A61Q19/00 ,  A61Q19/10 ,  C08G65/002 ,  C08G65/34

Abstract: A polyether-polyol compound represented by the compositional formula C3nH6n+2O2n+1, wherein n is an integer of 4 or more, wherein the polyether-polyol compound has a total number of 1,2-diol unit and 1,3-diol unit of [(n/2)+1] in a case where n is an even number of 4 or more, or a total number of 1,2-diol unit and 1,3-diol unit of [((n−1)/2)+1] and one hydroxyl group which is not involved in the units in a case where n is an odd number of 5 or more; a polyglycerol alkyl ether, a part of hydroxyl groups in a polyglycerol being substituted by an alkyl group, wherein the polyglycerol is the polyether polyol compound mentioned above; and an ester prepared by the process comprising reacting the polyether-polyol compound mentioned above or the polyglycerol alkyl ether mentioned above with a fatty acid.

Abstract translation: 由组成式C3nH6n + 2O2n + 1表示的聚醚多元醇化合物，其中n为4以上的整数，其中聚醚多元醇化合物的总数为1,2-二醇单元和1,3-二醇单元 在n为4以上的偶数的情况下，[（n-2）+1]的1,2-二醇单元和1,3-二醇单元的总数为[（（n-1）+1] / 2）+1]和在n为奇数为5以上的情况下不参与单元的一个羟基; 聚甘油烷基醚，聚甘油中的一部分羟基被烷基取代，其中聚甘油是上述聚醚多元醇化合物; 和通过使上述聚醚 - 多元醇化合物或上述聚甘油烷基醚与脂肪酸反应的方法制备的酯。

公开(公告)号：US06509509B2

公开(公告)日：2003-01-21

申请号：US09750101

申请日：2000-12-29

Applicant: Claudio Tonelli ,  Antonio Russo ,  Ezio Strepparola

Inventor： Claudio Tonelli ,  Antonio Russo ,  Ezio Strepparola

IPC: C07C4311

CPC classification number: C08G65/324 ,  C08G65/007

Abstract: A process for preparing perfluoropolyoxyalkylenes with hydroxyl end groups having structure: T1—CFW1—O—Rf—CFW2—T2  (I) wherein: T1, T2, are selected from —CH2OH, —F, —CF3, —CF2CF3 with the proviso that at least one of T1 and T2 is —CH2OH; W1 and W2 are selected from F, CF3; Rf is a perfluoropolyoxyalkylene chain having a number average molecular weight 500-10,000 comprising one or more units of the type —CF2CF2O—, —CF2O—, —C3F6O—, —CF2(CF2)zCF2O— (z=1,2); —CR4R5CF2CF2O— with R4 and R5 selected from H, Cl, perfluoroalkyl group; said process comprising the following steps: a) adding an ester precursor having structure (I) and T1, T2 end groups selected from —F, —CF3, —CF2CF3, —COOR (R=linear or branched alkyl group having a number of C atoms from 1 to 5), with the proviso that at least one of T1 and T2 is —COOR, in a reaction mixture formed by: an inert or protic reaction solvent; a reducing agent selected from metal hydrides; an unreactive organic base with respect to the ester; b) hydrolysis of the product obtained in step a) for obtaining the compounds of structure (I) with at least a —CH2OH end group.

Abstract translation: 制备具有以下结构的羟基端基的全氟聚氧化烯的方法：其中：T1，T2选自-CH2OH，-F，-CF3，-CF2CF3，条件是T1和T2中的至少一个为-CH2OH; W1和W2 选自F，CF 3; Rf是数均分子量为500-10,000的全氟聚氧亚烷基链，其包含一种或多种-CF 2 CF 2 O-，-CF 2 O-，-C 3 F 6 O-，-CF 2（CF 2）z CF 2 O-（z = 1,2）; -CR4R5CF2CF2O-，其中R4和R5选自H，Cl，全氟烷基; 所述方法包括以下步骤：a）加入具有结构（I）和T1的酯前体，T2端基选自-F，-CF 3，-CF 2 CF 3，-COOR（R =直链或支链烷基，其数目为C 原子从1至5），条件是至少一个T1和T2是-COOR，在由惰性或质子反应溶剂形成的反应混合物中;还原剂选自金属氢化物;非反应性有机碱，相对于 酯化; b）在步骤a）中获得的产物的水解，得到至少具有-CH 2 OH端基的结构（I）化合物。

公开(公告)号：US06482993B1

公开(公告)日：2002-11-19

申请号：US09673583

申请日：2000-10-18

Applicant: Jörg Hofmann ,  Pramod Gupta

Inventor： Jörg Hofmann ,  Pramod Gupta

IPC: C07C4311

CPC classification number: B01J31/0227 ,  B01J2231/48 ,  C08G65/2642 ,  C08G65/266

Abstract: This invention relates to a process for the production of long-chain polyether polyols without working up, in which oligomeric, alkoxylated starter compounds having molecular weights of 200 to 1000 are first obtained by catalysis with perfluoroalkylsulfonates of the metals of group III A of the periodic system of elements (in accordance with the IUPAC convention of 1970) from low molecular weight starters by reaction with alkylene oxides at reaction temperatures of 80 to 200° C. and catalyst concentrations of 5 to 200 ppm, which oligomeric, alkoxylated starter compounds are then converted without working up and removal of the catalyst by means of highly active DMC catalysts at a catalyst concentration of 30 ppm or below, relative to the quantity of polyether polyol to be produced, by reaction with alkylene oxides into higher molecular weight, long-chain polyether polyols.

Abstract translation: 本发明涉及一种不加工的长链聚醚多元醇的制备方法，其中分子量为200〜1000的低聚烷氧基化起始化合物首先通过周期性的IIIA族金属的全氟烷基磺酸盐的催化而得到 在低分子量起始化合物的反应温度为80〜200℃，催化剂浓度为5〜200ppm的条件下，通过与环氧烷烃反应，从低分子量起始剂中分离出元素系统（按照IUPAC惯例） 通过高活性DMC催化剂处理和除去催化剂，催化剂浓度为30ppm或更低，相对于待生产的聚醚多元醇的量，通过与烯化氧反应成较高分子量的长链 聚醚多元醇。